Relationship between fatty liver, coronary calcium score, multiple-sites atherosclerosis and 10-years Framingham Score

Pais, Raluca; Giral, P.; Ratziu, Vlad

doi:10.1016/s0168-8278(17)31603-3

Cited by 1 publication

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“…Carotid IMT was found to be significantly associated with elevated serum levels of glucose in the 2 hours postprandial measures, Hb A 1 C, LDL, HDL triglyceride (TG) and cholesterol, which is agreed with Stubbs et al (23) . Carotid IMT was found not to be associated with serum levels of aspartate aminotransferase (AST) or alanine aminotransferase (ALT), which is against Pais et al (24) findings that might be attributed to the difference in racial background in the study groups.…”

Section: Discussioncontrasting

confidence: 73%

Relationship Between Serum Adipocyte Fatty Acid Binding Protein and Atherosclerosis in Type 2 Diabetes Patients

Al-Barshomy

Allam

Tantawi

2021

The Egyptian Journal of Hospital Medicine

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Background: Atherosclerosis as a complication of diabetes, is considered to be a chronic inflammatory disease, developing over years and proceeding through many steps. Adiposity fatty acid-binding protein (A-FABP) is highly expressed in mature adipocytes and plays a central regulatory role in energy metabolism and inflammation. A-FABP mRNA expression in adipose tissues predicted coronary artery disease in homozygous subjects. A-FABP may also play a role in the development of atherosclerotic diseases in humans. Objective: To detect the relationship between serum A-FABP level and carotid intima-media thickness (IMT) as indicator of atherosclerosis in patients with type 2 diabetes mellitus. Patients and methods: 124 patients with type 2 diabetes (T2D), were divided into two groups: Group 1: 62 patients with T2D ≤ 5 years duration, and Group 2: 62 patients with T2D > 5 years duration. They were subjected to full history taking, clinical examination, and laboratory investigations in the form of CBC, LFT, KFT, HBA1c, fasting and postprandial blood sugar, A-FABP serum level, and carotid Doppler. Results: Serum level A-FABP and carotid IMT was significantly higher in long standing diabetes group compared to short standing diabetes group. A-FABP cutoff was proven to have a high sensitivity 94.4%, specificity 100.0%, positive predictive value of 100.0%, negative predictive value of 97.7% and overall accuracy of 98.3% regarding the prediction of atherosclerosis. Conclusions: A-FABP serum level have a high sensitivity, specificity, predictive value and overall accuracy regarding atherosclerosis, and should be recommended as a part of routine surveillance for atherosclerosis in patients with type 2 diabetes.

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Section: Discussioncontrasting

confidence: 73%