Relationship between frailty and lower urinary tract symptoms among community‐dwelling adults

Abstract

Objectives: To evaluate the relationship between frailty and lower urinary tract symptoms (LUTS), the association of frailty and LUTS remains unclear. Methods: This cross-sectional study investigated LUTS and frailty in 710 individuals (249 men and 461 women, aged ≥60 years) who participated in the Iwaki Health Promotion Project between 2014 and 2015 in Hirosaki, Japan. Parameters of frailty were compared for individuals with mild and moderate to severe symptoms of LUTS. The International Prostate Symptom Score (IPSS) and Overactive Bladder Symptom Score (OABSS) were used to evaluate LUTS. Frailty was evaluated by the frailty phenotype (FP), modified frailty index (mFI), and frailty discriminant score (FDS). The influence of frailty on LUTS was investigated by multivariate logistic regression analyses.Results: Frailty parameters of age, renal function, and lower physical activity were significantly associated with severity of IPSS and OABSS. FP and mFI were significantly associated with severity of OABSS and IPSS, respectively. The FDS was significantly associated with severity of IPSS and OABSS. FP, mFI, and FDS were significantly associated with severity of nocturia. Multivariate logistic regression analyses revealed that FDS was independently associated with the severity of IPSS, OABSS, and nocturia, whereas FP and mFI were significantly associated with the severity of nocturia alone.Conclusions: Individuals with LUTS are potentially frailer than those without LUTS.Although the influence of frailty on LUTS is different depending on the measurement tool, attention for frailty is necessary for subjects with LUTS.

Co‐Occurrence of Lower Urinary Tract Symptoms and Frailty among Community‐Dwelling Older Men

“…However, frailty phenotype and modified frailty index were not significantly associated with LUTS. 2 Our study significantly improves on the existing evidence with rigorous adjustment for confounding and a large sample size of community-dwelling older American men that minimizes selection bias and allows for more detailed investigations of associations with LUTS subtypes and individual frailty criteria.…”

“…To our knowledge only a few small studies with important limitations have evaluated the association between LUTS and frailty in older men. [1][2][3] A better understanding of how LUTS are related to frailty will inform whether these two age-related conditions are likely to co-occur among men of similar age and risk factor profile.…”

STone Episode Prediction: Development and validation of the prediction nomogram for urolithiasis

“…We retrospectively analyzed the clinical data of 1305 patients (Stone group) with the first episode of symptomatic urolithiasis who visited our hospitals from May 2010 to March 2018. The Ctrl group were selected from 2800 community‐dwelling individuals who underwent a comprehensive health survey between May 2006 and May 2016 in connection with the Iwaki Health Promotion Project, Hirosaki, Japan . The inclusion criteria for the Stone group were as follows: (i) imaging results, such as ultrasound, excretory urography or computed tomography, that led to a diagnosis of urolithiasis; (ii) availability of clinical and laboratory data at the time of stone diagnosis, comprising age, sex, BMI (kg/m 2 ), eGFR (mL/min/1.73 m 2 ), Alb (g/dL), UA (mg/dL), HTN, CVD and DM.…”

“…The Ctrl group were selected from 2800 community-dwelling individuals who underwent a comprehensive health survey between May 2006 and May 2016 in connection with the Iwaki Health Promotion Project, Hirosaki, Japan. [10][11][12][13][14][15][16] The inclusion criteria for the Stone group were as follows: (i) imaging results, such as ultrasound, excretory urography or computed tomography, that led to a diagnosis of urolithiasis; (ii) availability of clinical and laboratory data at the time of stone diagnosis, comprising age, sex, BMI (kg/m 2 ), eGFR (mL/min/1.73 m 2 ), Alb (g/dL), UA (mg/dL), HTN, CVD and DM. The exclusion criterion for the study was insufficient information against the criteria.…”

Editorial Comment to Incidence and risk factors of postoperative delirium in elderly patients undergoing urological surgery: A multi‐institutional prospective study

“…Although their study could not address the effect of frailty on postoperative delirium, impaired capacity for surgical stress might have serious effects on postoperative delirium. As the majority of patients with urological diseases are elderly, frailty assessment for these patients might be crucial to improve surgical and overall outcomes . Further studies are necessary to assess the relationship between frailty and postoperative delirium.…”