Relationship between Gait Parameters and Postural Stability in Early and Late Parkinson's Disease and Visual Feedback-Based Balance Training Effects

Ahmed, Mohieldin M.; Mosalem, Douaa M.; Alfeeli, Aziz K.; Baqer, Ayyoub B.; Soliman, Doaa Youssry

doi:10.3889/oamjms.2017.051

Cited by 4 publications

(3 citation statements)

References 36 publications

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“…Gait, equilibrium and postural disorders are linked to neurological and neurodegenerative pathologies. 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 Gait is a complex activity requiring the activation of the cerebral cortex, basal ganglia, cerebellum, brainstem, spinal cord and the musculoskeletal system. 14 , 15 , 16 , 17 , 18 Independent papers by Kaoru Takakusaki, Klaus Jahn and Anat Mirelman et al, 14 , 15 , 16 extensively discuss human locomotion and the key regions associated with gait and posture i.e., the mesencephalic locomotor region (MLR) and its projections to the pontomedullary reticular formation; the subthalamic locomotor region (SLR) and the cerebellar locomotor region (CLR).…”

Section: Introductionmentioning

confidence: 99%

Gait and balance disturbances are common in young urbanites and associated with cognitive impairment. Air pollution and the historical development of Alzheimer's disease in the young

Calderón‐Garcidueñas

Torres-Solorio

Kulesza

et al. 2020

Environmental Research

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To determine whether gait and balance dysfunction are present in young urbanites exposed to fine particular matter PM 2.5 ≥ annual USEPA standard, we tested gait and balance with Tinetti and Berg tests in 575 clinically healthy subjects, age 21.0±5.7y who were residents in Metropolitan Mexico City, Villahermosa and Reynosa. The Montreal Cognitive Assessment was also applied to an independent cohort n:76, age 23.3± 9.1y. In the 575 cohort, 75.4% and 34.4% had abnormal total Tinetti and Berg scores and high risk of falls in 17.2% and 5.7% respectively. BMI impacted negatively Tinetti and Berg performance. Gait dysfunction worsen with age and males performed worse than females. Gait and balance dysfunction were associated with mild cognitive impairment MCI (19.73%) and dementia (55.26%) in 57/76 and 19 cognitively intact subjects had gait and balance dysfunction. Seventy-five percent of urbanites exposed to PM 2.5 had gait and balance dysfunction. For MMC residents-with historical documented Alzheimer disease (AD) and CSF abnormalities, these findings suggest Alzheimer Continuum is in progress. Early development of a Motoric Cognitive Risk Syndrome ought to be considered in city dwellers with normal cognition and gait dysfunction. The AD research frame in PM 2.5 exposed young urbanites should include gait and balance measurements. Multicity teens and young adult cohorts are warranted for quantitative gait and balance measurements and neuropsychological and brain imaging studies in high vs low PM 2.5 exposures. Early identification of gait and balance impairment in young air pollution-exposed urbanites would facilitate multidisciplinary prevention efforts for modifying the course of AD.

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Section: Introductionmentioning

confidence: 99%

Gait and balance disturbances are common in young urbanites and associated with cognitive impairment. Air pollution and the historical development of Alzheimer's disease in the young

Calderón‐Garcidueñas

Torres-Solorio

Kulesza

et al. 2020

Environmental Research

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“…Daily activities, such as talking while walking, calculating while dressing, writing while listening to music are examples of dual-tasking and healthy people can perform multiple tasks with ease. There are a few studies on the effect of secondary cognitive or motor tasks increasing postural instability and fall risk in PD [8][9][10][11][12] . All of these studies are with patients with advanced disease.…”

Section: Introductionmentioning

confidence: 99%

Postural stability in early Parkinson’s disease: effect of cognitive dual-tasking

ERDEM

Balal

Demirkıran

2022

Cukurova Medical Journal

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Purpose: The primary aim of this study is to evaluate postural stability by using a static posturography in patients with early Parkinson’s disease (PD). Secondly, this paper addresses the need for illustrating the effect of dual-tasking on postural stability in early PD patients. Materials and Methods: Twenty-nine early PD patients with maximum 5 years of disease duration were included in this study. The selected group had no clinical PI while their age- and sex-matched healthy controls were carried out. Neurological examination and mini-mental state examination (MMSE) were performed in all subjects. Unified Parkinson Disease Rating Scale (UPDRS) and modified Hoehn and Yahr (H&Y) scores were recorded in PD patients. Postural stability was assessed in all subjects on a static posturography platform under three different conditions: eyes open, eyes closed and a cognitive task of producing words with given letters. Results: The mean age of the PD was 59.2±10.5 whereas the control groups mean age was 56.3±7.6 (p>0.05). The female-male ratio was 9/20 in the PD and 12/17 in the control group. There was no important difference between the two groups in terms of demographic characteristics. In the PD group, the mean UPDRS was 12.8±4.9. The patients were mostly receiving polytherapy. Eye closure and cognitive task caused an increase in most sway parameters in both groups. Conclusion: Early PD patients on medication, postural stability is preserved and cognitive dual-tasking does not affect postural stability in these patients in the early stage.

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“…Particularly, advances in small, body-worn, inertial sensors have made it possible to develop objective measures of multifaceted gait features, including the axial, upper, and lower body-related parameters 26,27 , aiming to provide a comprehensive profile of gait features and identify subtle gait alterations in the early stage of PD by quantifying multiple gait features 28 . Moreover, unlike the other multifaceted gait analysis based on the motion capture system [29][30][31] , the wearable sensor-based gait analysis does not involve expensive, highly technical, non-portable equipment which is limited to be applied in advanced biokinetics laboratory and makes it possible to develop quick, objective measures of balance and gait impairments in the clinic for research trials and clinical practice 26,27,32,33 .…”

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confidence: 99%

Wearable sensor-based quantitative gait analysis in Parkinson’s disease patients with different motor subtypes

Zhang,

Ling,

Chen

et al. 2024

npj Digit. Med.

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Gait impairments are among the most common and disabling symptoms of Parkinson’s disease and worsen as the disease progresses. Early detection and diagnosis of subtype-specific gait deficits, as well as progression monitoring, can help to implement effective and preventive personalized treatment for PD patients. Yet, the gait features have not been fully studied in PD and its motor subtypes. To characterize comprehensive and objective gait alterations and to identify the potential gait biomarkers for early diagnosis, subtype differentiation, and disease severity monitoring. We analyzed gait parameters related to upper/lower limbs, trunk and lumbar, and postural transitions from 24 tremor-dominant (TD) and 20 postural instability gait difficulty (PIGD) dominant PD patients who were in early stage and 39 matched healthy controls (HC) during the Timed Up and Go test using wearable sensors. Results show: (1) Both TD and PIGD groups showed restricted backswing range in bilateral lower extremities and more affected side (MAS) arm, reduced trunk and lumbar rotation range in the coronal plane, and low turning efficiency. The receiver operating characteristic (ROC) analysis revealed these objective gait features had high discriminative value in distinguishing both PD subtypes from the HC with the area under the curve (AUC) values of 0.7~0.9 (p < 0.01). (2) Subtle but measurable gait differences existed between TD and PIGD patients before the onset of clinically apparent gait impairment. (3) Specific gait parameters were significantly associated with disease severity in TD and PIGD subtypes. Objective gait biomarkers based on wearable sensors may facilitate timely and personalized gait treatments in PD subtypes through early diagnosis, subtype differentiation, and disease severity monitoring.

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Relationship between Gait Parameters and Postural Stability in Early and Late Parkinson's Disease and Visual Feedback-Based Balance Training Effects

Cited by 4 publications

References 36 publications

Gait and balance disturbances are common in young urbanites and associated with cognitive impairment. Air pollution and the historical development of Alzheimer's disease in the young

Gait and balance disturbances are common in young urbanites and associated with cognitive impairment. Air pollution and the historical development of Alzheimer's disease in the young

Postural stability in early Parkinson’s disease: effect of cognitive dual-tasking

Wearable sensor-based quantitative gait analysis in Parkinson’s disease patients with different motor subtypes

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