Relationship between gestational age and mode of delivery with neonatal septicemia

Mehar, Veerendra; Agarwal, Saksham; Singh, Ruby; Agarwal, Abhishek; Agrawal, Nikhar; Majethia, Aditi

doi:10.18203/2349-3291.ijcp20162361

Cited by 6 publications

(7 citation statements)

References 15 publications

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“…Previous studies have thrown light the reliability of procalcitonin in the diagnosis of neonatal sepsis, particularly in distinguishing causative agents, proving its value in excluding bacterial infections, with a negative predictive value of 93% [17][18]. Demographically, male children (61.3%) were more affected in our study, similar to the available reports (62.4%-65.9%) [19][20][21]. There is a genetic linking to the x-linked immuno-regulatory gene resulting in the host's susceptibility to the infection in males [22].…”

Section: Discussionsupporting

confidence: 86%

“…There is a genetic linking to the x-linked immuno-regulatory gene resulting in the host's susceptibility to the infection in males [22]. Available literature [23] undoubtedly indicates that low birth weight babies are more prone to develop neonatal sepsis (54.5%-66.0%) [19,24] due to immature physiological and immunological functions and maternal risks. Our study is in support of this observation as 53.0% of babies had a birth weight of <2.5Kg.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of Biomarkers of Neonatal Sepsis: Pro- Calcitonin Vs C-Reactive Protein

Akram

Naseem

2019

Int J Pediatr Res

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Background: Procalcitonin in neonatal sepsis (NS) has high sensitivity compared to C-reactive protein (CRP), but its specificity is not yet clearly defined. Objectives: Evaluation of Procalcitonin as an early marker, assessing its diagnostic utility in early-onset NS was the primary and comparing the levels of Procalcitonin with CRP was secondary objective. Method: In this observational, prospective study, neonates meeting the selection criteria were included and grouped into three, according to clinical symptoms of sepsis and blood culture. Results: Blood samples from 75 babies (male = 61.0%) were analysed; 63.0% and 37.0% were of gestational age (GA) ≥ 37 and < 37 and weeks, respectively. Birthweight <2.5 kg and >2.5 Kg was noted in 52.0% and 48.0%, respectively. Meconium stained liquor (n=34), premature rupture of membranes (n=19) and prolonged labour/instrumental delivery (n=13) were major maternal risk factors.General (45.33%), respiratory (25.33%), gastrointestinal (17.33%), cardiovascular (6.66%) symptoms were common presentation; forty one (55.0%) were negative for procalcitonin and 34 (45.0%) were positive; 61 (81.0%) tested negative for CRP, only 14 (19.0%) were positive with levels >10mg/mL. Procalcitonin positivity was statistically significant (<0.05) for males, term babies and with normal birth weight favouring procalcitonin. of seven positive blood culture, coagulase positive staphylococci (n= 03), Klebsiella(n= 02), E. coli (n=01), Pseudomonas (n=01) were isolated. On correlation with blood culture, Procalcitonin showed better sensitivity and negative predictive value. Conclusion: Procalcitoninis a better early marker than CRP in early onset NS. It hasbetter positivity for male, term and normal birth weight babies.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Comparison of Biomarkers of Neonatal Sepsis: Pro- Calcitonin Vs C-Reactive Protein

Akram

Naseem

2019

Int J Pediatr Res

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“…This result related to normal delivery methods which unhygienic, unsafe, and inadequate place of delivery that predispose to sepsis. 7 Most of subjects had general symptoms of hyperthermia (23/49; 47%), followed by hypoactivity in 19/49 (39%). A study found that the frequent clinical signs of neonatal sepsis were fever, tachypnea, breastfeeding intolerance and jaundice.…”

Section: Discussionmentioning

confidence: 94%

Ceftazidime as an empiric therapy for neonatal sepsis

Indrayady

Ramadanti²,

Iriani³

et al. 2021

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Background Sepsis is still the leading cause of death in neonates in developing countries. Proper administration of antibiotics is important for managing neonatal sepsis. The microorganisms that cause neonatal sepsis, as well as their sensitivity patterns, change over time and differ from one place to another. Since 2001, ceftazidime has been used as an empirical antibiotic for managing neonatal sepsis at Dr. Mohammad Hoesin Hospital, Palembang, South Sumatera, but its effectiveness is questionable. Objective To evaluate the effectiveness of ceftazidime as an empiric therapy for neonatal sepsis. Methods This study was pre-experimental, for one group, pre- and post-test, was conducted in 49 neonates with neonatal sepsis in the Neonatal Ward at Dr. Mohammad Hoesin Hospital, Palembang, South Sumatera, from April to September 2019. The effectiveness of ceftazidime was determined based on clinical and laboratory improvements 72 hours after ceftazidime administration. Results Of 49 neonates, 28 experienced clinical and laboratory improvement, while 21 experienced improvement in only one parameter, either clinical or laboratory. Gram positive bacteria were found in 22/49 subjects. Conclusion There is a significant difference on white blood cell count and CRP level between before and after ceftazidime administration but overall ceftazidime is no longer effective as empiric antibiotic therapy in neonatal sepsis.

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“…Neonatal sepsis is a life-threatening condition resulting from a bloodstream infection, in which bacteria, viruses or fungi are present during the first 28 days of life [6]. Premature infants are at a higher risk of acquiring sepsis than children and adults because of their immature immune systems [21]. Many risk factors lead to neonatal sepsis, including maternal, neonatal (host), and nosocomial factors.…”

Section: Discussionmentioning

confidence: 99%

Correlation Between Prematurity and The Onset of Neonatal Sepsis: A Cross-Sectional Study in NICU of a Tertiary Hospital in East Java, Indonesia

Nurrosyida¹,

Harum²,

Utomo³

2022

rmj

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INTRODUCTION: The incidence of neonatal sepsis in developing countries is still high, reaching 170 out of 1000 births. An increased premature birth rate has become the leading cause of death in children under five years old. Studies examining the correlation between prematurity and neonatal sepsis onset have not been widely reported. Therefore, we assessed the correlation between gestational age and the onset of sepsis in neonatal patients.METHODS: Hospital-based cross-sectional study was performed on all neonates diagnosed with neonatal sepsis in the NICU of a tertiary referral hospital in East Java between 1 January 2019 – 31 December 2019. Logistic regression was used to analyze the obtained data. P-value <0.05 was considered statistically significant. RESULTS: Of the 241 patients identified with neonatal sepsis at Dr. Soetomo General Hospital in 2019, we found that 161 patients met the inclusion criteria, with most patients being early-onset sepsis patients (67.7%), low birth weight (75.8%), premature (65.2%), singleton deliveries (92.5%), and cesarean section births (65.2%). Statistical analysis showed a non-significant correlation between prematurity and the onset of neonatal sepsis (p>0.05).CONCLUSION: Although preterm birth is often reported as one of the most important risk factors of neonatal sepsis, prematurity does not appear to be an independent risk factor of neonatal sepsis onset

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Relationship between gestational age and mode of delivery with neonatal septicemia

Cited by 6 publications

References 15 publications

Comparison of Biomarkers of Neonatal Sepsis: Pro- Calcitonin Vs C-Reactive Protein

Comparison of Biomarkers of Neonatal Sepsis: Pro- Calcitonin Vs C-Reactive Protein

Ceftazidime as an empiric therapy for neonatal sepsis

Correlation Between Prematurity and The Onset of Neonatal Sepsis: A Cross-Sectional Study in NICU of a Tertiary Hospital in East Java, Indonesia

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