Relationship Between Glycosylated Haemoglobin and Dyslipidaemia in Individuals Exposed to COVID-19: A Cross Sectional Study in North Indian Population

Abstract

Objective: To investigate the correlation between Glycosylated Hemoglobin and dyslipidemia in individuals exposed to COVID-19 in the Delhi/NCR region. Method: In the Delhi/NCR region, a total of 521 patient fasting blood samples were gathered from a NABL Accredited labs. These samples, collected between July 2020 and March 2022, consisted of 334 males and 187 females. HbA1C and lipid profile tests for the patients were conducted using conventional methods at a laboratory located in Gurugram. Findings: Among diabetic patients below 40 years of age, the mean HDL levels decreased to 40.3% compared to 42 mg/dl in non-diabetics. Increased glycosylated hemoglobin [more than 7%] with dyslipidemia noted in males 114 compared to females 64. A significant decrease in HDL levels were observed in diabetic patients above 40 years of age, with the mean level of HDL dropping to 33 mg/dl. The dyslipidemia was present in 80.9% of male diabetic patients and 88.6% of female diabetic patients. In diabetic male patients, a correlation between increasing triglyceride levels and the decreased HDL levels found. The mean triglyceride level in diabetic patients was 199 mg/dl, while the mean HDL level was 42 mg/dl. On the other hand, non-diabetic individuals had a mean triglyceride level of 105 mg/dl and an HDL level of 44 mg/dl. Novelty: Dyslipidemia is significantly associated with poorly controlled HbAa1c in T2DM than non-diabetic subjects after covid exposure. This observation points towards a U-shaped correlation between HDL and glycated haemoglobin in diabetic patients.