Relationship Between Gonadal Function and Cardiometabolic Risk in Young Men With Chronic Spinal Cord Injury

Sullivan, Shannon D.; Nash, Mark S.; Tefara, Eshetu; Tinsley, Emily A.; Groah, Suzanne L.

doi:10.1016/j.pmrj.2017.08.404

Cited by 17 publications

(16 citation statements)

References 48 publications

(70 reference statements)

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“…Our findings suggest that the addition of RT to low-dose TRT may be beneficial in inducing muscle hypertrophy of the trained thigh muscles and adjacent glutei muscles. Higher serum testosterone in men with SCI is linked to positive body composition [18] and cardiometabolic outcomes [29]. However, low-dose TRT administered in the current study was not enough to induce trunk, glutei or lower leg muscle hypertrophy.…”

Section: Clinical Relevance Of Hypertrophy Of the Glutei Musclescontrasting

confidence: 56%

A secondary analysis of testosterone and electrically evoked resistance training versus testosterone only (TEREX-SCI) on untrained muscles after spinal cord injury: a pilot randomized clinical trial

et al. 2019

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Study design: Secondary analysis of a clinical trial Objectives: To perform a secondary analysis on the effects of neuromuscular electrical stimulation resistance training (RT) combined with testosterone replacement therapy (TRT) compared to TRT on the untrained muscles after spinal cord injury (SCI). Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:

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Section: Clinical Relevance Of Hypertrophy Of the Glutei Musclescontrasting

confidence: 56%

A secondary analysis of testosterone and electrically evoked resistance training versus testosterone only (TEREX-SCI) on untrained muscles after spinal cord injury: a pilot randomized clinical trial

et al. 2019

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“…The authors showed that persons with lower BMI have serum T level greater than 300ng/dL compared to those with BMI > 25.26 kg/m 2 [12]. In contrast, a recent study showed that BMI was not an influential factor in determining the serum T level in persons with SCI, whereas total body % fat mass was an accurate determinant of circulating serum T level [13]. In the current study, persons with normal T-level (>555 ng/dl) had an average BMI of 21.5 kg/m 2 ; which was significantly lower than those with low-T level (Table 1).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have investigated the association between serum T levels and body composition [13] as well as biomarkers of cardiometabolic health [12,13] in men with SCI and able-bodied men [14]. However, regional body composition assessments were not captured to examine the association of serum T levels with total and regional lean mass, thigh skeletal muscle cross-sectional area (CSA), intramuscular fat (IMF) and VAT [15,16].…”

Section: Introductionmentioning

confidence: 99%

Serum testosterone levels may influence body composition and cardiometabolic health in men with spinal cord injury

et al. 2018

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Study Design: Cross-sectional study Objective To establish the association between serum testosterone (T) levels, biomarkers of cardiometabolic health and regional body composition variables after spinal cord injury (SCI). Setting: Medical research center Methods Metabolic and body composition measurements were collected from thirty-six men with chronic motor complete SCI. Serum T, carbohydrate and lipid profiles were measured after an overnight fast. Body composition was measured using anthropometrics, dual energy x-ray absorptiometry and magnetic resonance imaging. Participants were evenly classified into tertiles based on their serum T levels into low, mid-normal and normal ranges. Results Low, mid-normal and normal range serum T were 288.8 ± 84.9ng/dL, 461.0 ± 52.5ng/dL and 648.0 ± 53.5ng/dL, respectively. Low range serum T group had greater total (9.6%, P = 0.04) percentage fat mass and visceral adipose tissue (VAT) area (72%, P = 0.01) compared to normal range serum T group. Serum T was related to the absolute whole thigh muscle area ( r = 0.40, P< 0.05) after controlling for body mass index. Serum T was negatively related to fasting plasma glucose ( r = −0.46, P = 0.006) and insulin ( r = −0.42, P = 0.01), HbA1c ( r = −0.39, P = 0.02) and triglycerides ( r = −0.36, P = 0.03). Conclusion Men with low serum T have more unfavorable body composition and cardiometabolic health outcomes after SCI. Testosterone replacement therapy may serve as a potential strategy in preventing cardiometabolic disorders after SCI.

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“…62 In young men with chronic spinal cord injury and an accelerated aging process after injury, hypogonadism is linked to an adverse cardiometabolic measure. 63 Therefore, high-quality randomized controlled studies are required to investigate the efficacy and safety of TRT in this population with an increased risk of cardiometabolic diseases. 64 Long-term T therapy reduces the risk of CVD with improvement in cardiometabolic function in men with hypogonadism.…”

Section: Androgens In Cmsmentioning

confidence: 99%

The Effects of Androgens on Cardiometabolic Syndrome: Current Therapeutic Concepts

et al. 2020

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Introduction: Cardiometabolic syndrome (CMS), as a bunch of metabolic disorders mainly characterized by type 2 diabetes mellitus (T2DM), hypertension, atherosclerosis, central adiposity, and abdominal obesity triggering androgen deficiency, is one of the most critical threats to men. Although many significant preclinical and clinical findings explain CMS, new approaches toward common pathophysiological mechanisms and reasonable therapeutic targets are lacking. Aim: To gain a further understanding of the role of androgen levels in various facets of CMS such as the constellation of cardiometabolic risk factors including central adiposity, dyslipidemia, insulin resistance, diabetes, and arterial hypertension and to define future directions for development of effective therapeutic modalities. Methods: Clinical and experimental data were searched through scientific literature databases (PubMed) from 2009 to October 2019. Main Outcome Measure: Evidence from basic and clinical research was gathered with regard to the causal impact and therapeutic roles of androgens on CMS. Results: There are important mechanisms implicated in androgen levels and the risk of CMS. Low testosterone levels have many signs and symptoms on cardiometabolic and glycometabolic risks as well as abdominal obesity in men. Clinical Implications: The implications of the findings can shed light on future improvements in androgen levels and add potentially predictive risk for CMS, as well as T2DM, abdominal obesity to guide clinical management in the early stage. Strengths & Limitations: This comprehensive review refers to the association between androgens and cardiovascular health. A limitation of this study is the lack of large, prospective population-based studies that analyze the effects of testosterone treatment on CMS or mortality. Conclusion: Low testosterone levels have several common features with metabolic syndrome. Thus, testosterone may have preventive role in the progress of metabolic syndrome and subsequent T2DM, abdominal obesity, and cardiovascular disease and likely affect aging men's health mainly through endocrine and vascular mechanisms. Further studies are necessary to evaluate the therapeutic interventions directed at preventing CMS in men. Kirlangic OF, Yilmaz-Oral D, Kaya-Sezginer E, et al. The Effects of Androgens on Cardiometabolic Syndrome: Current Therapeutic Concepts. Sex Med 2020;8:132e155.

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Relationship Between Gonadal Function and Cardiometabolic Risk in Young Men With Chronic Spinal Cord Injury

Abstract: IV.

Cited by 17 publications

References 48 publications

A secondary analysis of testosterone and electrically evoked resistance training versus testosterone only (TEREX-SCI) on untrained muscles after spinal cord injury: a pilot randomized clinical trial

A secondary analysis of testosterone and electrically evoked resistance training versus testosterone only (TEREX-SCI) on untrained muscles after spinal cord injury: a pilot randomized clinical trial

Serum testosterone levels may influence body composition and cardiometabolic health in men with spinal cord injury

The Effects of Androgens on Cardiometabolic Syndrome: Current Therapeutic Concepts

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