Relationship between guanosine triphosphate pathway and tetrahydrobiopterin in gestational diabetes mellitus

Ünüvar, Songül; Melekoğlu, Rauf; Şalva, Emine; Acar, Ceren; Yaşar, Şeyma

doi:10.1007/s40200-020-00659-1

Cited by 3 publications

(3 citation statements)

References 36 publications

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“…NO is known to actively regulate trophoblast invasion, placental angiogenesis, and vascular development, as well as placental vascular function (3,8). Changes in placental tissue levels of eNOS and iNOS, as well as changes in plasma levels of NO metabolites, have also been observed in pregnancy pathologies such as gestational diabetes (9,10), preeclampsia (11,12), and fetal growth restriction (13,14). Although the importance of NO to placental function is clear, the molecular pathways through which NO exerts its effects on placental function are less certain.…”

mentioning

confidence: 99%

Iron nitrosyl complexes are formed from nitrite in the human placenta

Mukosera

Principe

Mata‐Greenwood

et al. 2022

Journal of Biological Chemistry

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mentioning

confidence: 99%

Iron nitrosyl complexes are formed from nitrite in the human placenta

Mukosera

Principe

Mata‐Greenwood

et al. 2022

Journal of Biological Chemistry

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“…The activity of iNOS in group 4 was 1.35 times greater than in group 2. Based on this, increased NO production from NOS is a consequence of insulin deficiency (systemic factor) [2,4,12,14].…”

Section: Results and Their Discussionmentioning

confidence: 99%

“…Due to hyperglycemia, metabolism in periodontal tissues may be disrupted, which in turn may leads to the progression of inflammatory processes [8]. Pathogenetically important features of endocrinological diseases such as DM are angiopathy, namely in the vessels of the microcirculatory tract; autoaggression and the occurrence of secondary immunodeficiency; changes in lipid peroxidation; metabolic disorders, which may disrupt function of periodontal tissues [4,6,14].…”

mentioning

confidence: 99%

Functioning of No-Cycle in the Saliva of Children With Type 1 Diabetes Mellitus

Kuz¹,

Akimov²,

Костенко³

et al. 2021

PEP

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Introduction. The presence of type 1 diabetes mellitus in children is a major risk factor for periodontal disease. The aim of research work was to determine the activity of NO-synthase and arginase in saliva in children age with insulin-dependent diabetes mellitus. Materials and methods We examined 82 children including 56 children with type 1 diabetes mellitus and 26 children without somatic diseases. NO-synthase (NOS) activity was determined by the difference in nitrite concentration before and after incubation of tissue homogenate. Determining arginase activity was based on analysis the difference in the concentration of L-ornithine before and after incubation in phosphate buffer solution. Statistical processing was performed using Microsoft Office Excel. Research results and their discussion The violation of the indicators’ balance between groups 1 and 3 showed us a decrease in regenerative capacity in the mucous membrane in persons with type 1 diabetes mellitus. Increased ARG activity in group 4 children may lead to rivarly between NOS and ARG for L-arginine. Increased ARG activity in groups 2 and 4 compared with group 1 indicated an adaptive response aimed at repairing gum damage. Based on this, increased NO production from NOS is a consequence of insulin deficiency (systemic factor). Conclusions. The combination of systemic factor (type 1 diabetes mellitus) and local (chronic catarrhal gingivitis) leads to dysregulation of the NO-cycle and increasing of competition between NOS and ARG. ФУНКЦИОНИРОВАНИЕ NO-ЦИКЛА В СЛЮНЕ У ДЕТЕЙ С САХАРНЫМ ДИАБЕТОМ І ТИПА Кузь И.А., Акимов О.Е., Костенко В.А., Шешукова О.В., Максименко А.И., Писаренко Е.А. Полтавский государственный медицинский университет Вступление. Наличие у детей сахарного диабета І типа является основным фактором риска заболеваний пародонта. Целью исследования было определение активности NO-синтазы и аргиназы в слюне у детей с инсулинозависимым сахарным диабетом. Материалы и методы. Обследовано 82 ребенка, в том числе 56 детей с сахарным диабетом І типа и 26 детей без соматических заболеваний. Активность NO-синтазы (NOS) определяли по разнице в концентрации нитрита до и после инкубации гомогената ткани. Определение активности аргиназы основывалось на анализе разницы в концентрации L-орнитина до и после инкубации в фосфатном буферном растворе. Статистическая обработка проводилась с использованием Microsoft Office Excel. Результаты исследований и их обсуждение. Нарушение баланса показателей между 1 и 3 группами свидетельствовало о снижении регенерационной способности слизистой оболочки у лиц с сахарным диабетом І типа. Повышенная активность ARG у детей группы 4 может привести к неравенству между NOS и ARG для L-аргинина. Повышенная активность ARG в группах 2 и 4 по сравнению с группой 1 указала на адаптивный ответ, направленный на восстановление повреждений десен. Исходя из этого, повышенная продукция NO из NOS является следствием дефицита инсулина (системный фактор). Выводы. Сочетание системного фактора (сахарный диабет І типа) и местного (хронический катаральный гингивит) приводит к нарушению регуляции NO-цикла и усилению конкуренции между NOS и ARG.

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