Relationship between gut microbiota, probiotics, and type 2 diabetes mellitus

Salgaço, Mateus Kawata; Oliveira, Liliane Garcia Segura; Costa, Giselle Nobre; Bianchi, Fernanda; Sivieri, Kátia

doi:10.1007/s00253-019-10156-y

Cited by 120 publications

(80 citation statements)

References 81 publications

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“…There is evidence supporting that probiotics can improve some parameters of the risk factors of CVD, like obesity. A recent systematic review reported that specific strains from Lactobacillus and Bifidobacterium have been generally used as probiotic treatment in well-established animal models of obesity [203] and in blood lipid index, T2D and hypertension [200,201,[204][205][206].…”

Section: Probiotic Administration Microbiota Bile Acids and Cardiovmentioning

confidence: 99%

“…Furthermore, a meta-analysis suggests that the supplementation of probiotics has a modest effect on the serum level of fasting blood sugar as well as oxidative stress biomarkers [211]. Mechanisms that have been proposed are as follows: improved intestinal integrity, decreased systemic lipopolysaccharide levels, decreased endoplasmic reticulum stress and improved peripheral insulin sensitivity [204,212]. Data from clinical studies and animal models have shown a reduction in lipopolysaccharide translocation, endotoxemia and inflammation, reducing stimulation of the proinflammatory genes like tumor necrosis factor alpha (TNF-α), IL-6 and IL-1β [204,213].…”

Section: Probiotic Administration Microbiota Bile Acids and Cardiovmentioning

confidence: 99%

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The Gut Microbiota and Its Implication in the Development of Atherosclerosis and Related Cardiovascular Diseases

et al. 2020

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The importance of gut microbiota in health and disease is being highlighted by numerous research groups worldwide. Atherosclerosis, the leading cause of heart disease and stroke, is responsible for about 50% of all cardiovascular deaths. Recently, gut dysbiosis has been identified as a remarkable factor to be considered in the pathogenesis of cardiovascular diseases (CVDs). In this review, we briefly discuss how external factors such as dietary and physical activity habits influence host-microbiota and atherogenesis, the potential mechanisms of the influence of gut microbiota in host blood pressure and the alterations in the prevalence of those bacterial genera affecting vascular tone and the development of hypertension. We will also be examining the microbiota as a therapeutic target in the prevention of CVDs and the beneficial mechanisms of probiotic administration related to cardiovascular risks. All these new insights might lead to novel analysis and CVD therapeutics based on the microbiota.

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Section: Probiotic Administration Microbiota Bile Acids and Cardiovmentioning

confidence: 99%

Section: Probiotic Administration Microbiota Bile Acids and Cardiovmentioning

confidence: 99%

The Gut Microbiota and Its Implication in the Development of Atherosclerosis and Related Cardiovascular Diseases

et al. 2020

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“…Lactobacillus genus acting as probiotic is bene cial to healthy intestinal microbiota, creates a favorable intestinal environment, and alleviates T2DM [30]. We observed that BBR treatment reduced the levels of Lactobacillaceae family and Lactobacillus genus, whereas BBR combined with Sta reversed the reduction to a higher percentage than those seen in control mice.…”

Section: Discussionmentioning

confidence: 62%

Stachyose improves the anti-diabetic effects of berberine by regulating intestinal microbiota and SCFAs in spontaneous type 2 diabetic KKAy mice

Cao

Lei

et al. 2020

Preprint

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Background: Berberine (BBR) has the beneficial effects of anti-inflammation, anti-bacteria, and anti-diabetes. The clinical application of BBR has been hindered by its poor gastrointestinal absorption. Stachyose (Sta), a prebiotic agent, improves the composition of gut microbiota and benefits for diabetes. We therefore investigated whether Sta improves the anti-diabetic actions of BBR using type 2 diabetic KKAy mice.Methods: KKAy mice were randomly divided into four groups: Con, Sta (200 mg/kg), BBR (100 mg/kg), and BBR+Sta (BBR: 100 mg/kg, Sta: 200 mg/kg). Mice were administered intragastrically once daily for 8 weeks. The mice weight, glycemia, glycated hemoglobin, and levels of insulin, glucagon, and inflammatory cytokines were monitored. Oral glucose tolerance tests and insulin tolerance tests were performed; protein and gene expression levels were detected by Western blot and qRT-PCR, respectively; gut microbiota and short-chain fatty acids (SCFAs) in feces were analyzed.Results: The combination of BBR and Sta is more effective than BBR alone in blood glucose control, improvement of insulin resistance and islet functions, inflammatory mediators decrease, and maintenance of intestinal barrier integrity. Gut microbiota analysis demonstrates that both BBR and combination treatments enhance the abundance of Bacteroidaceae and Akkermansiaceae and decrease Lachnospiraceae levels, whereas Akkermansiaceae elevation due to the administration of BBR with Sta is more significant than BBR alone. Interestingly, the proportion of Lactobacillaceae increases with combination treatment, but is diminished by BBR treatment. Additionally, BBR with Sta significantly reduces the concentrations of fecal SCFAs compared to BBR.Conclusions: The combination of BBR and Sta imparts better effects on the maintenance of glycemia and intestinal homeostasis than BBR alone by modulating gut microbiota and SCFAs, thereby providing a novel approach for the treatment of type 2 diabetes mellitus.

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“…Additionally, gut-derived bacterial inflammatory molecules such as lipopolysaccharide and peptidoglycans are believed to accelerate inflammation in T2DM when they accumulate in the intestine [74]. According to Sabatino et al, the reduction in butyrate-producing bacteria such as Roseburia intestinalis and Faecalibacterium prausnitzii is characteristic for T2DM patients [78].…”

Section: Type 2 Diabetesmentioning

confidence: 99%

Role of the gut microbiota in human health

Chałupnik¹,

Chilimoniuk²,

Sobstyl³

et al. 2020

J Educ Health Sport

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Introduction: The human gut microbiota has become the subject of extensive research in recent years and the knowledge of the species inhabiting the gut is growing rapidly. Microbiota plays an important role in human health and diseases. It takes part in obtaining and storing energy, as well as in metabolic functions. The aim of the study: The purpose of the study is to collect and review scientific publications about the impact of gut microbiota on human health. Material and method: The paper uses standard criteria as the research method. The articles used to create the reviews were published on the PubMed and Google Scholar platforms. Description of the state of knowledge: Numerous studies suggest that composition of intestinal microbiota has impact on the long-term functioning of the human organism. Depressive disorders appear to be associated with changes in the microbiota. In depressed patients, fewer bacteria of the type Bacteroidetes and higher level of Alistipes are found. A few studies have demonstrated a link between gut microbial signatures and hypertension. Studies have shown that T2DM patients may have an altered composition of gut microbiota, mainly a decreased Bacteroidetes/ Firmicutes ratio and decrease in some functional bacteria when compared to healthy people. Intestinal microorganisms are also a key element in the proper functioning of the immune system by influencing the maturation process of the immune system's cells. Summary: To sum up, numerous studies indicate that abnormal composition of the intestinal microflora is the cause of not only faster development of metabolic syndrome, but also other diseases. It influences the development of circulatory, nervous or immune system diseases. Its abnormal composition is influenced by many factors such as diet, lifestyle or antibiotic therapy.

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Relationship between gut microbiota, probiotics, and type 2 diabetes mellitus

Cited by 120 publications

References 81 publications

The Gut Microbiota and Its Implication in the Development of Atherosclerosis and Related Cardiovascular Diseases

The Gut Microbiota and Its Implication in the Development of Atherosclerosis and Related Cardiovascular Diseases

Stachyose improves the anti-diabetic effects of berberine by regulating intestinal microbiota and SCFAs in spontaneous type 2 diabetic KKAy mice

Role of the gut microbiota in human health

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