Relationship between H.Pylori infection and clinicopathological features and prognosis of gastric cancer

Abstract

BackgroundAimed to assess the relationship between H.Pylori and the clinicopathological features and prognosis of gastric cancer by quantitative detection of H.Pylori.Methods157 patients were enrolled, all patients had a record of clinicopathological parameters. Specimens including the tumor and non-neoplastic were detected for H.Pylori by Real-Time PCR and analyzed clinical data retrospectively. Variables independently affecting prognosis were investigated by means of multivariate analysis using the Cox proportional hazards model.ResultsH.Pylori infection was greater in non-neoplastic tissue than the tumor tissue (p < 0.05), H.Pylori infection and its copies were related to the tumor site and N staging (p < 0.05). Overall survival (OS) in all 157 patients has no correlation with the H.Pylori infection status (p = 0.715). As to the patients who underwent a curative surgery, relapse-free survival (RFS) has no correlation with the H.Pylori infection status (p = 0.639). Among the H.Pylori positive patients, OS and RFS of those with higher copies were longer than in patients with low copies, but there was no significant statistical difference.ConclusionsH.Pylori infection status and its copies were related to N staging. The OS and RFS in patients with positive H.Pylori status has no significant difference from the patients with negative H.Pylori status.

Helicobacter pylori Infection Predicts Favorable Outcome in Patients with Gastric Cancer

“…In agreement with most studies in the literature, we found that the rate of H. pylori positivity was higher in non-neoplastic tissue than in tumour tissue 18 . The possible biologic basis might be elucidated as follows: Once cancer developed, sustained injury to the gastric mucosa persisted.…”

“…An overall positivity rate of 72.0% was observed in our patients. That value is higher than the rates reported in other Asian studies 18,26 , which might be explained by epidemiologic factors and the sensitivity of the various methods used to detect H. pylori infection. Moreover, it is well known that a high prevalence of H. pylori is always accompanied by a high incidence of gastric cancer 27 .…”

“…Currently, the available data suggest a controversial role of H. pylori infection in the prognosis of patients with gastric cancer, and because of regional differences in H. pylori prevalence and gastric cancer incidence, the effect of H. pylori status on prognosis should be determined in various areas. To the best of our knowledge, only one retrospective study, by Qiu et al 18 , has been reported in China, which is well-known as a H. pylori endemic area. In that study, overall survival (os) in 157 gastric cancer patients had no correlation with H. pylori status.…”

“…Based on an association between H. pylori infection and the risk of gastric cancer, some investigations have focused on the relationship between H. pylori status and gastric cancer prognosis [15][16][17][18][19] . Currently, the available data suggest a controversial role of H. pylori infection in the prognosis of patients with gastric cancer, and because of regional differences in H. pylori prevalence and gastric cancer incidence, the effect of H. pylori status on prognosis should be determined in various areas.…”

Gastric Cancer: Clinical Aspects, Epidemiology and Molecular Background

“…H. pylori was more prevalent in nontumor tissue, and its presence was related to tumor site and N-stage, whereas there was no correlation to overall or recurrence-free survival after curative surgery [26].…”