Relationship between heart-type fatty acid-binding protein levels and coronary artery disease in exercise stress testing: an observational study

Arı, Hatem; Tokaç, Mehmet; Alihanoğlu, Yusuf İzzettin; Kiyici, Aysel; Kayrak, Mehmet; Mehtap, Arı; Sönmez, Osman; Gök, Hasan

doi:10.5152/akd.2011.189

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…A similar increase was observed during a 21 km time trial run at submaximal intensity [58]. However, such H-FABP changes were not observed in exercise tests involving individuals with coronary artery disease [59,60]. Our study revealed an increase in H-FABP concentration after a single intense exercise session in both hypoxia and normoxia among athletes, with no difference in the magnitude of these changes between conditions.…”

Section: Heart-type Fatty Acid-binding Protein (H-fabp)supporting

confidence: 82%

The Impact of Normobaric Hypoxia and Intermittent Hypoxic Training on Cardiac Biomarkers in Endurance Athletes: A Pilot Study

Goliniewski,

Czuba,

Płoszczyca

et al. 2024

IJMS

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This study explores the effects of normobaric hypoxia and intermittent hypoxic training (IHT) on the physiological condition of the cardiac muscle in swimmers. Hypoxia has been reported to elicit both beneficial and adverse changes in the cardiovascular system, but its impact on the myocardium during acute exercise and altitude/hypoxic training remains less understood. We aimed to determine how a single bout of intense interval exercise and a four-week period of high-intensity endurance training under normobaric hypoxia affect cardiac marker activity in swimmers. Sixteen young male swimmers were divided into two groups: one undergoing training in hypoxia and the other in normoxia. Cardiac markers, including troponin I and T (cTnI and cTnT), heart-type fatty acid-binding protein (H-FABP), creatine kinase-MB isoenzyme (CK-MB), and myoglobin (Mb), were analyzed to assess the myocardium’s response. We found no significant differences in the physiological response of the cardiac muscle to intense physical exertion between hypoxia and normoxia. Four weeks of IHT did not alter the resting levels of cTnT, cTnI, and H-FABP, but it resulted in a noteworthy decrease in the resting concentration of CK-MB, suggesting enhanced cardiac muscle adaptation to exercise. In contrast, a reduction in resting Mb levels was observed in the control group training in normoxia. These findings suggest that IHT at moderate altitudes does not adversely affect cardiac muscle condition and may support cardiac muscle adaptation, affirming the safety and efficacy of IHT as a training method for athletes.

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Section: Heart-type Fatty Acid-binding Protein (H-fabp)supporting

confidence: 82%

The Impact of Normobaric Hypoxia and Intermittent Hypoxic Training on Cardiac Biomarkers in Endurance Athletes: A Pilot Study

Goliniewski,

Czuba,

Płoszczyca

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Furthermore, a recent dobutamine stress echocardiography (DSE) study reported significantly increased levels of serum H-FABP at 1 hour in the presence of DSE-induced ischemia, in contrast to DSE negative group, whose serum H-FABP remained unchanged before and 1 hour after the test 24 . However, in a study that was expected H-FABP to increase during exercise stress testing (EST), serum H-FABP tended to decline statistically significant from the basal level to 3 hours after the EST 25 . A recent systemic review of H-FABP in ACS found marked heterogeneity in the prognostic impact of H-FABP between studies, reflecting differences in sampling times and the population at risk.…”

Section: Discussionmentioning

confidence: 99%

The prognostic significance of heart-type fatty acid binding protein in patients with stable coronary heart disease

Tseng

et al. 2018

Sci Rep

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To investigate the prognostic value of heart-type fatty acid binding protein (H-FABP) in patients with stable coronary heart disease (SCHD). A total of 1,071 patients with SCHD were prospectively enrolled in this Taiwan multicenter registry study, followed for 24 months. The cut-off value of H-FABP, 4.143 pg/mL, was determined using receiver operating characteristic curves. The primary cardiovascular (CV) outcome was composite CV events, defined as cardiovascular or cerebrovascular death, myocardial infarction (MI), stroke, angina related-hospitalization, PAOD-related hospitalization and heart failure. Secondary outcomes included CV or cerebrovascular death, nonfatal MI, nonfatal stroke, and acute heart failure-related hospitalization. We found that the high H-FABP group had more than a two-fold higher rate of primary CV outcomes than the low H-FABP group (32.36% vs. 15.78%, p < 0.001). Eleven patients (4.82%) of the high H-FABP group died during the 24 months of follow-up, compared to only one patient (0.12%) in the low H-FABP group. The acute heart failure-related hospitalization rate was also significantly higher in the high H-FABP group (3.5% vs. 0.95%, p < 0.005). The results remained significant after adjusting for baseline covariates. In conclusion, H-FABP was an independent predictor for CV outcomes in the patients with SCHD, mainly in CV death and acute heart failure-related hospitalization.

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Serum heart-type fatty acid-binding protein decreases and soluble isoform of suppression of tumorigenicity 2 increases significantly by long-term physical activity

Sponder

Lichtenauer

Wernly

et al. 2019

Journal of Investigative Medicine

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The aim of this prospective study was to investigate the influence of long-term physical activity on biomarkers for myocyte ischemia (heart-type fatty acid-binding protein, H-FABP), matrix remodelling/vascular stress (soluble isoform of suppression of tumorigenicity 2, sST2) and inflammation (soluble urokinase-type plasminogen activator receptor, suPAR). In this prospective observational study 109 subjects were recruited, 98 completed the study. Subjects were asked to perform exercise within the calculated training pulse for 8 months. The performance gain was measured/quantified by bicycle stress tests at the beginning and end of the observation period. Twenty-seven subjects with a performance gain <2.9% were excluded. suPAR, H-FABP and sST2 were measured in serum at baseline and after 2, 4 and 8 months by ELISA. We found a significant decrease in H-FABP (1.86 (0.86) to 1.29 (0.98) ng/mL; p<0.01) and a significant increase in sST2 levels (6126 (2759) to 6919 (3720) pg/mL; p=0.045) during the observation period of 8 months while there was no remarkable change in suPAR levels. We interpret the activity-induced decrease in H-FABP as sign of lower subclinical myocardial ischemia and better perfusion, probably due to a more economic metabolization and electrolyte balance. The increase in sST2 might reflect physiological sports-induced vascular stress. As H-FABP and sST2 play an important role in the pathomechanism of ischemic cardiomyopathy (iCMP) further studies should investigate the influence of regular physical activity on these biomarkers in a population of patients with iCMP.Trial registration number NCT02097199.

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Relationship between heart-type fatty acid-binding protein levels and coronary artery disease in exercise stress testing: an observational study

Cited by 4 publications

References 36 publications

The Impact of Normobaric Hypoxia and Intermittent Hypoxic Training on Cardiac Biomarkers in Endurance Athletes: A Pilot Study

The Impact of Normobaric Hypoxia and Intermittent Hypoxic Training on Cardiac Biomarkers in Endurance Athletes: A Pilot Study

The prognostic significance of heart-type fatty acid binding protein in patients with stable coronary heart disease

Serum heart-type fatty acid-binding protein decreases and soluble isoform of suppression of tumorigenicity 2 increases significantly by long-term physical activity

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