Relationship between Heavy Metal Exposure and Bone Mineral Density in Korean Adult

Lim, Hee‐Sook; Lee, Hae-Hyeog; Kim, Tae-Hee; Lee, Bora

doi:10.11005/jbm.2016.23.4.223

Cited by 53 publications

(28 citation statements)

References 15 publications

(15 reference statements)

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“…Regarding the concentrations of heavy metals in blood, our results showed no correlation between the concentrations, age and osteopenia, which is consistent with Lim et al's research (20). Since the concentrations in the blood mainly reflect the intake levels of heavy metals from the external environment and diet, our data suggested that the history of exposure to heavy metals was consistent in all patients.…”

Section: Table 5 Pearson's Correlation Analysis Between Osteopenia Ansupporting

confidence: 91%

Study on the relationship between age and the concentrations of heavy metal elements in human bone

Chang¹,

Shen²,

Zhang³

et al. 2018

Ann. Transl. Med.

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Background: Excessive amounts of heavy metals such as cadmium, chromium, cobalt, lead, thallium, and manganese are extremely harmful to the human body. These elements can accumulate in bone and impact bone metabolism. In this study, we investigated the relationship between age and the concentrations of these elements in human bone and blood. Methods: Bone and blood samples were obtained from both older and younger patients. The concentrations of the elements under investigation were measured by inductively coupled plasma mass spectrometry (ICP-MS), and the specific concentrations in the bone and blood were then calculated. Results: The results showed that with increasing age, the concentrations of chromium, cobalt, and thallium in bone decreased significantly, while the concentration of cadmium in bone markedly increased. However, there was no clear correlation between age and the concentrations of these heavy metals in blood. Notably, there was a close correlation between the concentration of cobalt in bone and the presence of osteopenia. Conclusions: Senescence of the human body is accompanied by the shifting of cobalt, chromium, and thallium from the bone to the outer-bone. However, the concentration of cadmium in bone increases with age. These changes are very likely to be related to the equilibrium of bone metabolism in senescent individuals. In addition, only cobalt was shown to be significantly related to osteopenia.

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Section: Table 5 Pearson's Correlation Analysis Between Osteopenia Ansupporting

confidence: 91%

Study on the relationship between age and the concentrations of heavy metal elements in human bone

Chang¹,

Shen²,

Zhang³

et al. 2018

Ann. Transl. Med.

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“…This study did not find a statistically significant difference in PbB levels according to sex, age, family income, schooling, smoking, consumption of locally produced foods, or BMI. Although some of these association have already been reported in other studies, especially related to age 24,38,39 , the sample's composition (with 83% men) may have influenced the result. However, among the eight individuals that presented concentrations within the previously mentioned exposure range (5-10µg dL -1 ), five were overweight (55.55%) and one was severely obese (11.11%), while only two showed normal BMI (22.22%).…”

Section: Pbb (μG DLmentioning

confidence: 74%

Avaliação dos níveis de chumbo e mercúrio em população exposta ambientalmente na Região Centro-oeste do Brasil

et al. 2018

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The objective was to assess the level of exposure to lead and mercury in a population in the Pantanal region in Mato Grosso State, Brazil. Blood lead (PbB) (n = 119) and urinary mercury (HgU) (n = 109) in local residents were measured by atomic absorption spectrometry. Comparison of means and correlations between variables used analysis of variance (ANOVA) and linear regression, respectively, with 95% confidence intervals. Mean PbB was 2.82 ± 1.53µg dL-1. The comparison of PbB stratified by collection site (p ≤ 0.01), work activity (p ≤ 0.01), and consumption of locally produced cow's milk (p ≤ 0.05) showed statistically significant differences. There were also positive associations between PbB and collection site (p ≤ 0.01), participants' profession (p ≤ 0.05), local milk (p ≤ 0.01), and source of drinking water (p ≤ 0.01). Mean HgU was 1.41 ± 0.98µg L-1. The levels only showed significant differences for participants' profession (p ≤ 0.01), and positive associations emerged between HgU and work activity (p ≤ 0.01) and body mass index (p ≤ 0.01). The samples showed low lead and mercury levels, similar to those found in other environmentally exposed populations. Despite these low concentrations, current knowledge on the toxicity of these metals shows that health effects can already be felt at levels that were previously considered safe, thus characterizing a health hazard.

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Section: Introductionmentioning

confidence: 99%

“…Bone is one of the important target organs of heavy metals, and heavy metal toxicity is associated with several degenerative processes, such as osteoporosis and bone mineral alterations, that could lead to fractures [ 1 , 2 ]. Exposure to heavy metals occurs through various routes, and quantifying absorbed doses is complex because of the levels of absorption and metabolism [ 2 ]. In addition, exposure duration varies widely among individuals, with polluted or fresh water, soil, dermal contact of soil, air, smoking, and food being the primary routes of exposure [ 2 , 3 , 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Exposure to heavy metals occurs through various routes, and quantifying absorbed doses is complex because of the levels of absorption and metabolism [ 2 ]. In addition, exposure duration varies widely among individuals, with polluted or fresh water, soil, dermal contact of soil, air, smoking, and food being the primary routes of exposure [ 2 , 3 , 4 , 5 , 6 , 7 ]. In the case of cadmium, for non-smokers, food consumption has been identified as the major pathway of cadmium exposure, accounting for 90% of the cadmium exposure compared to other routes of exposure [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Dietary Intake of Cadmium, Lead and Mercury and Its Association with Bone Health in Healthy Premenopausal Women

Lavado‐García

Puerto-Parejo

Roncero-Martín

et al. 2017

IJERPH

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The bone is one of the relevant target organs of heavy metals, and heavy metal toxicity is associated with several degenerative processes, such osteoporosis and bone mineral alterations, that could lead to fractures. We aimed to study a presumed relationship between bone density, evaluated by quantitative bone ultrasound (QUS), dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) and the dietary intake of cadmium, lead and mercury in healthy premenopausal women. A total of 158 healthy, non-smoking, premenopausal women were incorporated into the study. A validated food frequency questionnaire (FFQ) was administered to assess intake during the preceding seven days. The median predicted dietary cadmium intake among the 158 women studied was 25.29 μg/day (18.62–35.00) and 2.74 μg/kg body weight/week (b.w./w) (1.92–3.83). Dietary lead intake was 43.85 μg/day (35.09–51.45) and 4.82 μg/kg b.w./w (3.67–6.13). The observed dietary mercury intake was 9.55 μg/day (7.18–13.57) and 1.02 μg/kg b.w./w (0.71–1.48). Comparisons, in terms of heavy metal intake, showed no significant results after further adjusting for energy intake. No statistically significant correlations between heavy metal intake and the QUS, DXA and pQCT parameters were observed. Levels of dietary exposure of cadmium, lead and mercury were mostly within the recommendations. We did not find associations between the QUS, DXA and pQCT parameters and the dietary intake of the studied heavy metals in healthy premenopausal women.

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Relationship between Heavy Metal Exposure and Bone Mineral Density in Korean Adult

Cited by 53 publications

References 15 publications

Study on the relationship between age and the concentrations of heavy metal elements in human bone

Study on the relationship between age and the concentrations of heavy metal elements in human bone

Avaliação dos níveis de chumbo e mercúrio em população exposta ambientalmente na Região Centro-oeste do Brasil

Dietary Intake of Cadmium, Lead and Mercury and Its Association with Bone Health in Healthy Premenopausal Women

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