Relationship between Helicobacter pylori infection and glaucoma11The authors have no commercial interests in the products or devices mention herein.

Kountouras, Jannis; Mylopoulos, Nikolaos; Boura, Panagiota; Bessas, Christos; Chatzopoulos, Dimitrios; Venizelos, J.; Zavos, Christos

doi:10.1016/s0161-6420(00)00598-4

Cited by 121 publications

(30 citation statements)

References 47 publications

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“…Apart from reactive oxygen metabolites, active granulocytes and macrophages release proinflammatory cytokines (TNF, IL -1, -6 and -8), arachidonic acid metabolites (prostaglandins, platelet-activating factor and leukotrienes), proteolytic and lipolytic enzymes; these substances also interact with the pancreatic microcirculation to augment vascular permeability, which induces thrombosis and hemorrhage and leads to pancreatic necrosis [65]. Helicobacter pylori infection could exacerbate these events by promoting platelet and plateletleukocyte aggregation, releasing large amounts of proinflammatory and vasoactive substances, such endothelin-1 (a potent constrictor of arterioles and venules), cytokines (IL -1, -6, -8, TNF-α), eicosanoids (leukotrienes, prostaglandins) or stimulating mononuclear cells to induce a tissue factorlike procoagulant activity that converts fibrinogen into fibrin [24,60,61,66].…”

Section: Helicobacter Pylori Autoimmunity and Apoptosismentioning

confidence: 99%

A concept on the role of Helicobacter pylori infection in autoimmune pancreatitis

2005

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Autoimmune pancreatitis, an inflammatory process of the pancreas due to an autoimmune mechanism establishing etiology of chronic pancreatitis, is characterized by the presence of autoantibodies, hypergammaglobulinemia, pancreatic enlargement, pancreatic duct strictures, and pathologic features of fibrotic changes with intense, mainly lymphocytic infiltrations, which may contribute to tissue destruction probably by apoptosis. In almost 60% of the cases, this type of pancreatitis coexists with other autoimmune diseases such as Sjögren's syndrome, sclerosing extrahepatic cholangitis, primary biliary cirrhosis, autoimmune hepatitis, or other extrapancreatic disorders, and recently with gastric peptic ulceration. The diversity of extrapancreatic lesions with similar histopathologic findings suggests general involvement of the digestive system in this disease, although the presence of such involvement has not been fully elucidated. Similarly, Helicobacter pylori (H. pylori) infection, a well known cause of gastric ulcer, has been associated, via molecular mimicry of host structures by its constituents with the same autoimmune conditions, also characterized by fibrotic changes and/or lymphoplasmacytic inflammations, accompanied by aberrations of T cell apoptosis that contribute to hepatobiliary-or extrahepatic-tissue destruction. Considering that H. pylori is involved in the pathogenesis and pathophysiology of these autoimmune disorders, we propose that this organism might trigger autoimmune pancreatitis through induction of autoimmunity and apoptosis.

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Section: Helicobacter Pylori Autoimmunity and Apoptosismentioning

confidence: 99%

A concept on the role of Helicobacter pylori infection in autoimmune pancreatitis

2005

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“…This recently discovered bacterium, which colonizes the stomach (first cultivated in 1983), did not attract many ophthalmologists’ attention until recently. Anti- H.-pylori antibodies have been detected by ELISA in the sera of only 1 child with idiopathic bilateral uveitis [33], in Behcet’s disease [34], in glaucoma patients [35] as well as in central serous chorioretinopathy [36]. The debate about H. pylori as a possible cause of acne rosacea is also current.…”

Section: Introductionmentioning

confidence: 99%

<i>Helicobacter pylori:</i> An Underestimated Factor in Acute Anterior Uveitis and Spondyloarthropathies?

et al. 2006

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Acute anterior uveitis (AAU) is the most common form of intraocular inflammation, but its aetiology is still unclear. Fifty percent of AAU patients are HLA-B27-positive, and half of these also have spondyloarthropathies (SpA). Numerous serological studies have shown elevated levels of serum antibodies to various Gram-negative bacteria in HLA-B27-positive AAU and SpA patients. Antigenic similarities between these bacteria and host components (HLA-B27) have already been shown. Still, the mechanism underlying these diseases has not been clarified. Among the Gram-negative bacteria, Helicobacter pylori has not been screened in AAU patients. The purpose of our study was to see if this common human pathogen somehow interferes with AAU. In addition Chlamydia trachomatis, Yersinia enterocolitica 03 and 09, Salmonella sp. and Proteus OX19 were also examined. A total of 60 patients consisting of 4 groups (15 patients with AAU, 15 with SpA, 15 with AAU+SpA and 15 healthy control persons) were examined. A high percentage of the serological results of all investigated bacteria was positive: 80% in the AAU, 93.3% in the SpA and 100% in the AAU+SpA group, while it amounted to 66.7% in the control group (p < 0.05). H. pylori showed the highest percentage of positivity in all 3 patient groups (66.7% in the AAU, 73.3% in the SpA and 80% in the AAU+SpA group). In contrast, 26.7% of the controls were anti-H.-pylori-positive, thus showing a statistically significant difference between the patients and the control group (p < 0.05). HLA-B27/B7-CREG positivity was detected in 53.3% of the AAU, 66.7% of the SpA and 93.3% of the AAU+SpA patients and in none of the controls. Our results suggest that H. pylori might be a candidate participating in the development of AAU and SpA. They also support the theory of genetic (HLA-B27) and exogenous factors (Gram-negative bacteria) as probable background of these diseases.

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“…Hp detection methods were reported previously [2,8]. Serum anti- Hp IgG antibody titers were assessed by the enzyme-linked immunosorbent assay (ELISA) method in all patients and healthy individuals.…”

Section: Methodsmentioning

confidence: 99%

“…Helicobacter pylori (Hp) is a curved spiral Gram-negative bacterium that colonizes the gastric mucosa of most humans worldwide, mainly affecting older adults in the developed world including Greece [2,3]. More than half of the world’s population is infected with this bacterium.…”

Section: Introductionmentioning

confidence: 99%

High Prevalence of <i>Helicobacter pylori</i> Infection in Greek Patients with Myelodysplastic Syndromes

Diamantidis

Ioannidou-Papagiannaki²,

Kountouras³

et al. 2010

Acta Haematol

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Background/Aims/Methods: To determine the frequency of Helicobacter pylori infection (Hp-I) in 73 patients with myelodysplastic syndromes (MDS) and 40 controls, serologic analyses of Hp and ¹³C-urease breath tests (INFAI) were performed. Gastric mucosal biopsy specimens were obtained to determine the presence of Hp-I using a rapid urease test, i.e. the Campylobacter-like organism (CLO) test, and cresyl violet staining. Peripheral blood (PB) flow cytometry for CD3, CD4, CD8, CD14, CD19 and CD34 was conducted in 35 patients and in controls. Results:Hp-I was detected by: (a) serology in 75.34% of patients (p = 0.000), (b) INFAI in 57.69% of patients, (c) CLO in 60.71% of patients and (d) histological confirmation in 80.36% of patients (p = 0.001). No correlation between Hp-I and CD3, CD4, CD8, CD14, CD19 expression, leukemic transformation or death was observed. However, in 20 cases, significant variation in the PB lymphocytic proportion possibly attributable to Hp-I was ascertained, in contrast to the expected MDS ratio. Conclusion: Although there is no evidence for a causal relationship between Hp-I and MDS, the increased prevalence of Hp-I among the MDS patients is an interesting finding that deserves further investigation as it may indicate a common factor causing susceptibilities to both MDS and Hp-I or that Hp might influence the pathophysiology of MDS.

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Relationship between Helicobacter pylori infection and glaucoma11The authors have no commercial interests in the products or devices mention herein.

Cited by 121 publications

References 47 publications

A concept on the role of Helicobacter pylori infection in autoimmune pancreatitis

A concept on the role of Helicobacter pylori infection in autoimmune pancreatitis

<i>Helicobacter pylori:</i> An Underestimated Factor in Acute Anterior Uveitis and Spondyloarthropathies?

High Prevalence of <i>Helicobacter pylori</i> Infection in Greek Patients with Myelodysplastic Syndromes

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