Relationship between Helicobacter pylori infection and obesity in Chinese adults: A systematic review with meta-analysis

Xu, Xin-lan; Li, Weide; Lan, Qing; Yang, Wenhui; Guowei, Yu; Wei, Qishan

doi:10.1371/journal.pone.0221076

Cited by 57 publications

(52 citation statements)

References 50 publications

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“…16 Regarding association of H. pylori infection with gall stones, it was more common in H. pylori negative cases (82%) as compared to H pylori positive cases (76%). The results were similar to that of another study in which the prevalence of gallstones in H pylori positive cases was lower than in the H pylori-negative cases (odds ratio, 0.653) 11 In our study, fibrosis was present in most of the H pylori positive cases (94%) whereas it was less (79%) in non-infected patients proving its association with chronic cholecystitis. In another study, 36% cases of H pylori positive group had fibrosis but the same frequency was also seen in H pylori negative group and therefore no statistically significant difference was noted regarding fibrosis between both the groups 16 When analyzed statistically, comparison of patients with H pylori positive and H pylori negative was not found significant in any of the findings.…”

Section: Discussionsupporting

confidence: 91%

“…Hyperlipidemia, sedentary lifestyle, low fiber, high fat diet, metabolic syndrome and diabetes are the commonest causative factors of gallstone formation leading to cholecystitis. 4 In recent years, few studies from Middle East 5 and Asia (China, 4,6,7 , Iran, 8,9, India 10,11 ) have identified a new causative agent "H pylori" which plays a role in gall stone formation leading to cholecystitis. The initial study dates back to 1996 by Kawaguchi et al 12 who incidentally discovered a microorganism resembling H pylori from a cholecystectomy specimen.…”

Section: Original Articlementioning

confidence: 99%

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Association of Clinicopathological features of cholecystitis with H.pylori infection in Gall bladders

Jimdc¹,

Mushtaq²

2019

JIMDC

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Background: Since H pylori has been mostly associated with gastritis its presence in other parts of gastrointestinal system has not been studied much. Few previous studies have identified “H pylori” in gallbladder and found its association in causing cholecystitis and gallstones but only a few studies have been performed in Pakistan that have shown a significant association. Therefore, in this study we looked for the presence of this microorganism in cholecystitis patients and its association with the morphological changes seen in gall bladders. Material and method: All patients with acute and chronic cholecystitis admitted in ANTH between the ages of 18 and 75 years from January 2017 till March 2019, who underwent cholecystectomy, were included in the study. Gall bladder specimens after surgery were sent to Pathology department ANTH and specimens were analyzed for the presence of H pylori bacteria using H&E and Giemsa staining. Signs of inflammation, any hyperplasia, metaplasia, mucosal atrophy or erosion, lymphoid infiltration, fibrosis, cholesterolosis or any other morphological changes were also noted. Association of H.pylori with cholecystitis and other morphological changes were checked by Chi Square analysis. P. value less than 0.05 was considered statistically significant Results: Chronic cholecystitis was present in 91% cases and acute cholecystitis in 9%. Other histological findings were Hyperplasia (10%), Metaplasia (15%), Fibrosis (79%), Cholesterolosis (19%) and ulcerations (36%). H pylori was found in 17% of gall bladders and all the cases were of chronic cholecystitis. Among these, there were 11.7% Males and 88% Females. Gallstones were present in 76.4% cases and age group involvement was seen more among 41-60 years (64.7%). Other histological findings seen in hpylori positive cases were; Hyperplasia in 11.7% cases, Metaplasia in 17.6%, Fibrosis in 94.1%, cholesterolosis in 23.5% and ulcerations in 17.6% cases. Association of H-Pylori with gender, cholecystitis, gall stones, histological features and age distribution was non-significant. Conclusion: Although H pylori infection has been found in cases of chronic cholecystitis and gall stone formation, its association with cholecystitis and other morphological changes could not be proved. Hence, it is uncertain whether H pylori eradication in patients with gastritis can prevent cholecystitis or gall stones formation

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Section: Discussionsupporting

confidence: 91%

Section: Original Articlementioning

confidence: 99%

Association of Clinicopathological features of cholecystitis with H.pylori infection in Gall bladders

Jimdc¹,

Mushtaq²

2019

JIMDC

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“…Moreover, Ad36 infection was shown to induce acute and chronic in ammation leading to angiogenesis in fatty tissues (49). Another systematic review by Xu et al concludes that Helicobacter pylori infection may be a risk factor for the development of obesity (50). However, a causal relationship cannot be established due to the nature of the study design of the included studies.…”

Section: Viral Infections May Induce Obesitymentioning

confidence: 99%

SARS-CoV-2 and Obesity: “CoVesity” - A Pandemic Within A Pandemic

Zakka

Chidambaram

Mansour

et al. 2020

Preprint

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Individuals who are overweight or obese are in a chronic state of low-grade inflammation, making them particularly susceptible to developing severe forms of respiratory failure. Studies conducted in past pandemics link obesity with worse health outcomes. This population is thus of particular concern within the context of the COVID-19 pandemic, considering the cessation of obesity management services. This systematic review highlights (1) the reciprocal link between the obesity and COVID-19 pandemics (2) obesity as a risk factor for more severe disease in past pandemics, (3) potential mechanisms that make obese individuals more susceptible to severe disease and higher viral load, (4) the need to safely resume bariatric services as recommended by expert guidelines, in order to mitigate the health outcomes of an already vulnerable population.

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“…The OR value showed that H. pylori ‐positive subjects tended to be obese at a risk of 1.20 (95% CI: 1.13‐1.28). However, the study did not establish a causal relationship between H. pylori infection and obesity 18 . Whether there is a positive or a negative correlation between H. pylori and obesity remains to be answered.…”

Section: Discussionmentioning

confidence: 82%

Lack of association between Helicobacter pylori infection and childhood overweight/obesity

et al. 2020

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Background The reduction in the prevalence of Helicobacter pylori (H. pylori) infection in developed countries coincides with the increasing incidence of obesity and might be a contributing factor to the obesity epidemic. We aimed to evaluate the association between H. pylori infection and childhood overweight/ obesity in Israeli children. Material and Methods Patients diagnosed with H. pylori infection by endoscopy, histology, and a positive culture, between January 2013 and August 2018, were identified and compared with H. pylori‐negative children, of the same age and gender, undergoing endoscopy for the same indications during the same time period. Data collected included the following: age, gender, height, weight, BMI, BMI percentile, and the indication for endoscopy. Patients with missing anthropometric data or having a disease affecting growth were excluded. Results We included 146 H. pylori‐positive children and 146 age‐ and gender‐matched H. pylori‐negative patients. 63.7% (186/292) were female, mean age 13.1 ± 3.7. Overweight (BMI between the 85th‐95th percentile) and obesity (BMI > 95th percentile) were present in 56/292 (19.2%). Among the H. pylori‐positive children, 11.6% were overweight, 7.5% obese, among the H. pylori‐negative children, 10.3% were overweight, 8.9% obese, demonstrating no differences between the groups. The main indication for endoscopy was abdominal/ epigastric pain in 79.8% (233/292). The percent of children with a BMI ≥ 85% did not differ by gender age or the indication for endoscopy. Conclusions No association between H. pylori infection and childhood overweight/ obesity was demonstrated. This is in contrasts with previous pediatric studies demonstrating an inverse correlation.

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Relationship between Helicobacter pylori infection and obesity in Chinese adults: A systematic review with meta-analysis

Cited by 57 publications

References 50 publications

Association of Clinicopathological features of cholecystitis with H.pylori infection in Gall bladders

Association of Clinicopathological features of cholecystitis with H.pylori infection in Gall bladders

SARS-CoV-2 and Obesity: “CoVesity” - A Pandemic Within A Pandemic

Lack of association between Helicobacter pylori infection and childhood overweight/obesity

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