Relationship between High-density Lipoprotein-cholesterol and Malondialdehyde-modified Low-density Lipoprotein Concentrations

Abstract

Several reports have suggested that HDL has anti-oxidative actions. We investigated the relationship between HDL-cholesterol (HDL-C) and malondialdehyde-modified LDL (MDA-LDL) concentrations using enzyme linked immunosolvent assay. We divided our study subjects into four groups on the basis of concentrations of triglyceride (TG) and HDL-C by the following lipid profiles: serum TG < or = 1.69 mmol/L and HDL-C > or = 1.16 mmol/L (control group, n = 26); TG >1.69 and HDL-C < or = 1.16 (high TG group, n = 22); TG >1.69 and HDL-C < or = 0.91 (high TG & low HDL group, n = 67); TG < or = 1.69 and HDL-C < or = 0.91 (low HDL group, n = 21). MDA-LDL concentrations, MDA-LDL/apolipoprotein B (apo B) ratio, and LDL size were different between subjects in high TG & low HDL and control groups. MDA-LDL concentrations in both high TG and low HDL groups did not differ significantly from those in the control. However, MDA-LDL/apo B ratio in low HDL group was significantly higher than that in the control (P < 0.05). The MDA-LDL/apo B ratio reflects the extent of MDA modification of apo B in LDL. Therefore, our data suggest that as HDL-C concentrations fall, the extent of MDA modification per one LDL particle increases. Moreover, accompanied by high TG concentration, LDL size in subjects with lower HDL-C concentrations became smaller.

Effects of Pitavastatin, a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor, on Cardio-Ankle Vascular Index in Type 2 Diabetic Patients

“…Furthermore, increased oxidative stress and high levels of LDL may accelerate the production of oxidized LDL. The present results suggest that pitavastatin may decrease MDA-LDL, which is known to be a form of oxidized LDL 27,28) , by two major mechanisms: a systemic oxidative stress-ameliorating effect and a LDL-C-lowering effect.…”

Early Atherosclerotic Changes in the Patients with Idiopathic Epilepsy: Egyptian Preliminary Study

“…It has been reported that chronic treatment with AEDs was found to compete with cholesterol in the utilization of hepatic microsomal enzymes P-450 system which leads to reduction in the transformation of cholesterol in bile acids with increased serum cholesterol [24]. Hypercholesterolemia is known to result in increased endothelial permeability, retention of lipoproteins within the arterial intima, inflammatory cell recruitment and foam cell formation filled with oxidized-LDL, increase lipid peroxidation, induce vasoconstriction and enhance muscle wall proliferation and thrombotic properties [25].…”

HDL2 Can Inhibit Further Oxidative Modification of Partially Oxidized LDL

“…Oxidative modification of LDL may contribute to atherosclerosis by increasing its cytotoxic effects, by receptor-dependent uptake by scavengers, and by influencing the migration of monocytes effectively prevents lipid oxidation by metal ions in vitro and by cells in tissue culture 19) . In addition, it is suggested that as the HDL-cholesterol concentration falls in humans, the extent of malondialdehyde modification per LDL particle increases 20) . The HDL fraction in human plasma is in fact heterogenous.…”