Relationship between homocysteine and coronary artery disease. Results from a large prospective cohort study

Schaffer, Alon; Verdoia, Monica; Cassetti, Ettore; Marino, Paolo; Suryapranata, Harry; Luca, Giuseppe De

doi:10.1016/j.thromres.2014.05.025

Cited by 95 publications

(77 citation statements)

References 32 publications

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“…Epidemiological studies have shown that hyperhomocysteinemia, characterized by a serum homocysteine level >15 µmol/l, is not only associated with the onset of coronary artery disease (CAD) but also can predict the mortality of patients with CAD (3,4). Recent studies have reported that the blood homocysteine level is significantly associated with calcified plaque and the severity of CAD, assessed by computed tomography angiography and the Gensini scoring system (5-7).…”

Section: Introductionmentioning

confidence: 99%

Adropin is associated with hyperhomocysteine and coronary atherosclerosis

Zhao

You

Chan

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. Homocysteine has been recognized as a risk factor for atherosclerosis and cardiovascular diseases. Adropin is a newly-identified energy homeostasis protein with a potential protective effect against coronary artery disease (CAD). This study attempted to measure the correlation between serum homocysteine and adropin levels in patients with CAD, and to ascertain how the two hormones could affect the severity of coronary atherosclerosis. A cohort of CAD patients who had undergone coronary angiography was prospectively recruited. The serum homocysteine and adropin levels of the patients were measured and the severity of coronary atherosclerosis was quantified with the SYNTAX score. The data were analyzed with a generalized structural equation model. In total, 170 consecutive patients were recruited with a mean serum homocysteine level of 15.9±8.3 µmol/l, and 76 (44.7%) patients were identified as hyperhomocysteinemic with a serum homocysteine level >15 µmol/l. Serum homocysteine level was found to be significantly negatively correlated with serum adropin level (r=-0.169, P=0.028). Patients with hyperhomocysteinemia had lower serum adropin levels and higher SYNTAX scores than patients without hyperhomocysteinemia. Further analysis with a generalized structural equation model showed that adropin was significantly associated with hyperhomocysteinemia (adjusted odds ratio: 0.95, 95% confidence interval: 0.93 to 0.98; P=0.002), which in turn was significantly associated with the SYNTAX score (coefficient: 4.71, 95% confidence interval: 1.39 to 8.03; P=0.005). In conclusion, the serum homocysteine level was inversely correlated with the serum adropin level in patients with CAD. A low serum adropin level was associated with hyperhomocysteinemia and more severe coronary atherosclerosis, as reflected by a higher SYNTAX score.

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Section: Introductionmentioning

confidence: 99%

Adropin is associated with hyperhomocysteine and coronary atherosclerosis

Zhao

You

Chan

et al. 2015

Experimental and Therapeutic Medicine

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“…Homocysteine converts to cysteine as a result of trans-sulfuration pathway; each pathway depends on series of biochemical enzymes such as cystathionine β synthase and methylene tetrahydrofolate reductase (MTHFR) as well as on vitamin B12 and folic acid [5]. The formation of methylene-tetrahydrofolate is catalyzed by MTHFR enzyme which has an effect on the remethylation of homocysteine and these actions depend on vitamin B12 [6].…”

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confidence: 99%

Clinical Correlation between Plasma Homocysteine Level and Coronary Artery Disease in Indian Patients

Ranjith¹,

P²

2017

WJCD

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Objective: The aim of this study was to evaluate correlation between plasma homocysteine and coronary artery disease (CAD) in Indian patients. Methods: This study included 150 patients, 100 subjects in study group with angiographically diagnosed CAD and 50 subjects in control group with a normal coronary angiogram. In the study group, patients were divided into three subgroups viz.: CAD only, CAD with hypertension and CAD with type 2 diabetes mellitus. Plasma homocysteine, lipid profile and other risk factors were compared. Results: Mean homocysteine levels in study group (38.34 ± 15.25 μmol/L) were significantly higher (p < 0.01) than control group (9.41 ± 4.22 μmol/L). No association was found between homocysteine level and conventional risk factors. Furthermore, no significant correlation was found between plasma homocysteine and lipid components in different groups of patients. Conclusion: The study demonstrated that increased levels of homocysteine are independently related to CAD. However, further studies involving a larger sample size will be required to substantiate the findings of the current study.

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“…It may be another independent risk factor for coronary atherosclerotic heart disease [5]. Researches have shown that the increase of plasma homocysteine was closely related to the occurrence and development of atherosclerosis and was one of the independent risk factors for coronary atherosclerotic heart disease [6]. Hypothyroidism patients with high homocysteine hyperlipidemia predict a higher incidence of cardiovascular disease, especially closed with the atherosclerosis [7].…”

Section: Introductionmentioning

confidence: 99%

Predictive Value of Serum Lipid Ratio and Homocysteine Determination in Hypothyroidism Complicated with Coronary Heart Disease

Liu¹,

Hou²,

Zhang³

et al. 2017

SJPH

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Abstract:In recent years, with the improvement of detection technology and medical level, the incidence of hypothyroidism, subclinical hypothyroidism and coronary heart disease was increasing year by year and patients were often associated with significant reduction of high-density lipoprotein cholesterol, increase of total cholesterol and Homocysteine and so on. But it was not clear whether there was a similar change occurs in patients with hypothyroidism complicated with coronary heart disease. The authors chose hospital patients, who were divided into a group of hypothyroidism complicated with coronary heart disease (merging group), a group of hypothyroidism, subclinical hypothyroidism and control group, with 60 cases in each group, to measure the blood lipid and Homocysteine, calculate blood lipid ratio and make analysis. As a result, the authors found that patients with hypothyroidism and merging group serum high-density lipoprotein cholesterol decreased. The levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol, total cholesterol / high-density lipoprotein cholesterol, triglyceride / high-density lipoprotein cholesterol, low-density lipoprotein cholesterol / high-density lipoprotein cholesterol, lipid profile, non-high-density lipoprotein cholesterol and Homocysteine were significantly higher than the control group. And the group of patients with hypothyroidism complicated with coronary heart disease was higher than the hypothyroidism group. It came to the conclusion that dynamic monitoring of blood lipid and its ratio and the change of Homocysteine were important for clinical value in transforming subclinical hypothyroidism into hypothyroidism and predicting patients with hypothyroidism complicated with coronary heart disease.

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Relationship between homocysteine and coronary artery disease. Results from a large prospective cohort study

Cited by 95 publications

References 32 publications

Adropin is associated with hyperhomocysteine and coronary atherosclerosis

Adropin is associated with hyperhomocysteine and coronary atherosclerosis

Clinical Correlation between Plasma Homocysteine Level and Coronary Artery Disease in Indian Patients

Predictive Value of Serum Lipid Ratio and Homocysteine Determination in Hypothyroidism Complicated with Coronary Heart Disease

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