Relationship between Homocysteine and Muscle Strength Decline: The Baltimore Longitudinal Study of Aging

Vidoni, Michelle L.; Gabriel, Kelley Pettee; Luo, Sheng; Simonsick, Eleanor M.; Day, R. Sue

doi:10.1093/gerona/glx161

Cited by 44 publications

(35 citation statements)

References 38 publications

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“…In the MacArthur Studies of Successful Aging on 499 healthy and highly functional community-dwelling people (aged 70-79 years) [193], the authors observed that subjects with elevated plasma Hcy had an increased risk of functional decline over 3 years, with a 50% higher risk of being in the worst quartile of physical function (odds ratio = 1.5; 95% CI, 1.2-1.9) after multivariable adjustment. Similarly, in the Baltimore Longitudinal Study of Aging [194] on 1101 adults aged 50 years or older, in a follow-up of 4.7 years a significant inverse relationship between Hcy and grip strength was observed in women (β= −005, p = 0.031), while in men no significant results were observed, although an increase of 1 µmol/L in Hcy was associated with −0.10 kg decrease in grip strength. Oxidative damage of endothelial cells and deoxyribonucleic acid, telomere loss such as leukoaraiosis induced by HHCy, and bioavailability of nitric oxide [195] could be possible mechanisms involved in the relationship between Hcy and lowered physical function [193].…”

Section: Physical Functionmentioning

confidence: 88%

Homocysteine: Its Possible Emerging Role in At-Risk Population Groups

Azzini

Ruggeri

Polito

2020

IJMS

109

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Increased plasma homocysteine is a risk factor for several pathological disorders. The present review focused on the role of homocysteine (Hcy) in different population groups, especially in risk conditions (pregnancy, infancy, old age), and on its relevance as a marker or etiological factor of the diseases in these age groups, focusing on the nutritional treatment of elevated Hcy levels. In pregnancy, Hcy levels were investigated in relation to the increased risk of adverse pregnancy outcomes such as small size for gestational age at birth, preeclampsia, recurrent abortions, low birth weight, or intrauterine growth restriction. In pediatric populations, Hcy levels are important not only for cardiovascular disease, obesity, and renal disease, but the most interesting evidence concerns study of elevated levels of Hcy in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). Finally, a focus on the principal pathologies of the elderly (cardiovascular and neurodegenerative disease, osteoporosis and physical function) is presented. The metabolism of Hcy is influenced by B vitamins, and Hcy-lowering vitamin treatments have been proposed. However, clinical trials have not reached a consensus about the effectiveness of vitamin supplementation on the reduction of Hcy levels and improvement of pathological condition, especially in elderly patients with overt pathologies, suggesting that other dietary and non-dietary factors are involved in high Hcy levels. The importance of novel experimental designs focusing on intra-individual variability as a complement to the typical case–control experimental designs and the study of interactions between different factors it should be emphasized.

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Section: Physical Functionmentioning

confidence: 88%

Homocysteine: Its Possible Emerging Role in At-Risk Population Groups

Azzini

Ruggeri

Polito

2020

IJMS

109

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“…Although there are no studies examining performance outcomes related to MTHFR genotypes or dietary folate intake, hyperhomocysteinemia has been shown to be associated with diminished muscle function (111). Several studies conducted in older adults have found a significant association between elevated plasma homocysteine concentrations and declined physical function (119–122), which may be mediated by a reduction in strength (120). Compared to those with the rs1801133 CC genotype, individuals with TT genotype and possibly the CT genotype may be at a greater risk for hyperhomocysteinemia, although this may not be causative for lower physical performance (111, 119, 120).…”

Section: Genes Associated With Sport Nutritionmentioning

confidence: 99%

“…Several studies conducted in older adults have found a significant association between elevated plasma homocysteine concentrations and declined physical function (119–122), which may be mediated by a reduction in strength (120). Compared to those with the rs1801133 CC genotype, individuals with TT genotype and possibly the CT genotype may be at a greater risk for hyperhomocysteinemia, although this may not be causative for lower physical performance (111, 119, 120). However, soccer players and sedentary individuals with the CC genotype have been shown to have more favorable body composition and performance measures such as aerobic and anaerobic threshold rates, compared to carriers of the T allele (118).…”

Section: Genes Associated With Sport Nutritionmentioning

confidence: 99%

Sport Nutrigenomics: Personalized Nutrition for Athletic Performance

et al. 2019

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An individual's dietary and supplement strategies can influence markedly their physical performance. Personalized nutrition in athletic populations aims to optimize health, body composition, and exercise performance by targeting dietary recommendations to an individual's genetic profile. Sport dietitians and nutritionists have long been adept at placing additional scrutiny on the one-size-fits-all general population dietary guidelines to accommodate various sporting populations. However, generic “one-size-fits-all” recommendations still remain. Genetic differences are known to impact absorption, metabolism, uptake, utilization and excretion of nutrients and food bioactives, which ultimately affects a number of metabolic pathways. Nutrigenomics and nutrigenetics are experimental approaches that use genomic information and genetic testing technologies to examine the role of individual genetic differences in modifying an athlete's response to nutrients and other food components. Although there have been few randomized, controlled trials examining the effects of genetic variation on performance in response to an ergogenic aid, there is a growing foundation of research linking gene-diet interactions on biomarkers of nutritional status, which impact exercise and sport performance. This foundation forms the basis from which the field of sport nutrigenomics continues to develop. We review the science of genetic modifiers of various dietary factors that impact an athlete's nutritional status, body composition and, ultimately athletic performance.

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“…Besides, higher Hcy was marginally associated with muscle function decline in hyperhomocysteinemia hemodialysis patients aged 65 years and above. A previous longitudinal study has confirmed the association between higher homocysteine lower muscle strength in a general population aged 50 years or older [22]. Contributing factors such as age, low physical performance, and the presence of comorbidities were associated with muscle wasting [23].…”

Section: Discussionmentioning

confidence: 86%

Hyperhomocysteinemia Associated with Low Muscle Mass, Muscle Function in Elderly Hemodialysis Patients: An Analysis of Multiple Dialysis Centers

Wang

Wong

Duong

et al. 2019

BioMed Research International

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Background. The hyperhomocysteinemia was with high prevalence and has been considered as a risk factor for cardiovascular disease in hemodialysis patients. These patients also experienced a high risk of muscle wasting caused by the comorbidity, malnutrition, and low physical activity. We investigated the associations of homocysteinemia with muscle mass, muscle function in elderly hemodialysis patients. Methods. A clinical cross-sectional study was conducted on 138 hemodialysis patients aged 65 years and above in seven hospital-based hemodialysis centers in Taiwan. The data on anthropometry, laboratory, and 3-day dietary intake was examined. The skeletal muscle mass (SMM) was measured by the bioelectrical impedance analysis; the SMM was adjusted by height or weight as SMMHt2 (kg/m2) and SMMWt (%). Muscle function was defined as handgrip strength (HGS) (kg) measured by handgrip dynamometer. Statistical analyses were conducted using simple regression and multivariable stepwise regression analysis. Results. In the total sample, 74.6 % of hemodialysis patients were hyperhomocysteinemia (≥ 15 μmol/L). The means of SMMHt2, SMMWt, arm lean mass, hand grip strength, and muscle quality were 8.7 ± 1.2, 37.7 ± 5.6, 1.7 ± 0.5, 21.1 ± 7.4, and 10.0 ± 3.0, respectively. The multivariable stepwise regression analysis showed that homocysteinemia level was significantly inversely associated with SMMWt (B-coeff. = -0.03, p = 0.02) in hemodialysis patients above 65 years old, but not with muscle function. Conclusions. Hyperhomocysteinemia is common and associated with decreased muscle mass in the elderly hemodialysis patients. Future studies are suggested to explore the impact of the homocysteine-lowering therapy on muscle decline.

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Relationship between Homocysteine and Muscle Strength Decline: The Baltimore Longitudinal Study of Aging

Abstract: Background: Decreased muscle strength is strongly associated with future mobility limitations in older

Cited by 44 publications

References 38 publications

Homocysteine: Its Possible Emerging Role in At-Risk Population Groups

Homocysteine: Its Possible Emerging Role in At-Risk Population Groups

Sport Nutrigenomics: Personalized Nutrition for Athletic Performance

Hyperhomocysteinemia Associated with Low Muscle Mass, Muscle Function in Elderly Hemodialysis Patients: An Analysis of Multiple Dialysis Centers

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