Relationship Between Hormone Levels and Testicular Biopsies of Azoospermic Men

Merino, G; Jc, Martínez-Chéquer; Rg, Chan; Ml, Cuevas; Carranza-Lira, Sebastián

doi:10.1080/014850199262805

Cited by 6 publications

(4 citation statements)

References 26 publications

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“…Likewise, expression levels of CYP11A1 mRNA were increased in the testes of animals exposed to NP‐rich diesel exhaust (Ramdhan et al., 2009). Similarly, in male fertility prognosis, FSH is important in spermatogenesis and testicular development, and FSH is also a reliable indicator of primary testicular failure, oligozoospermia, azoospermia and Klinefelter's syndrome (Merino, Martinez‐Chequer, Chan, Cuevas, & Carranza‐Lira, 1999). Hence, a significant increase in the FSH level is suggested to be associated with germinal cell damage (Babu, Sadhnani, Swarna, Padmavathi, & Reddy, 2004) and decreased testicular activity, as well as inadequate testicular factors, which are involved in FSH secretion through a negative feedback (Karpas, Matsumoto, Paulsen, & Bremmer, 1983).…”

Section: Discussionmentioning

confidence: 99%

Alteration of sperm parameters and reproductive hormones in Swiss mice via oxidative stress after co‐exposure to titanium dioxide and zinc oxide nanoparticles

Ogunsuyi

Akanni

et al. 2020

Andrologia

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In this study, Swiss male mice were intraperitoneally administered with titanium dioxide (TiO 2) and zinc oxide (ZnO) nanoparticles (NPs) and their mixture (1:1) at doses between 9.38 and 75 mg/kg for 5 weeks to evaluate reproductive toxicity. Both NPs and their mixture significantly (p < .001) altered sperm motility, reduced sperm numbers and increased abnormalities, while their mixture induced more sperm abnormalities than either TiO 2 NPs or ZnO NPs. Both NPs and their mixture significantly (p < .05) reduced the LH level, while ZnO NPs alone and their mixture (p < .001) increased the testosterone levels at tested doses. The testes of exposed mice showed pathological changes and altered histomorphometrics. TiO 2 NPs and ZnO NPs individually induced a significant (p < .01) reduction in SOD and CAT activities, while the mixture significantly (p < .001) decreased CAT activity and increased SOD activity. TiO 2 NPs alone at 9.38 mg/kg induced a significant (p < .001) reduction in the GSH level, while both NPs and their mixture increased the MDA level significantly (p < .05). The data showed that the mixture had a synergistic interaction to induce testicular damage. Overall, oxidative stress may be involved in the NP-mediated testicular damage observed.

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Section: Discussionmentioning

confidence: 99%

Alteration of sperm parameters and reproductive hormones in Swiss mice via oxidative stress after co‐exposure to titanium dioxide and zinc oxide nanoparticles

Ogunsuyi

Akanni

et al. 2020

Andrologia

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“…On the other hand, FSH is an important hormone that plays a crucial role in testicular development combined with sperm production. However, a significant increase in concentration of serum FSH is a dependable baseline for main testicular failure, low sperm count, zero sperm in semen, and genetic inborn error [41]. In this study, significant upregulation of FSH in serum of envenomed rats may indicate damage associated with the germinal cell [42].…”

Section: Discussionmentioning

confidence: 65%

Echis ocellatus Venom-Induced Reproductive Pathologies in Rat Model; Roles of Oxidative Stress and Pro-Inflammatory Cytokines

Ajisebiola

Alamu

James

et al. 2022

Toxins

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This study reported reproductive pathologies associated with Echis ocellatus venom in animal model. Twenty male Wistar rats with body weight between 180 and 220 g were selected randomly into two groups (n = 10). Rats in group 1 served as the control while rats in group 2 were envenomed with a single intraperitoneal injection of 0.055 mg/kg−1 (LD6.25) of E. ocellatus venom on the first day and a repeated dose on the twenty fifth day. Both control and envenomed rats were monitored for fifty consecutive days. The venom caused a significant (p < 0.05) reduction in sperm motility, count, and volume, with increased sperm anomalies in envenomed rats compared to the control. Likewise, serum concentrations of male reproductive hormones were significantly (p < 0.05) higher in envenomed rats. Increased levels of malondialdehyde were accompanied by a significant (p < 0.05) decrease in reduced glutathione and catalase activity in the epididymis and testis tissues of envenomed rats. The venom enhanced the release of epididymal and testicular tumor necrosis factor-alpha and interleukin1-beta compared to the control. Furthermore, severe pathological defects were noticed in tissues of the testis and epididymis of envenomed rats. This study demonstrated that E. ocellatus venom toxins can induce reproductive dysfunction in male victims of snake envenoming.

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“…The hypothalamus secretes gonadotropin-releasing hormone, extent (Bhale & Mahat, 2013;Kauppila et al, 2010;Merino et al, 1999). In addition, T can affect sperm production by acting through androgen binding protein to chromatin in germ cells.…”

Section: Discussionmentioning

confidence: 99%

“…LH stimulates and regulates the production of T from Leydig cells and promotes sperm production. The increased secretion of FSH and LH promotes an increase in the levels of T. A feedback loop inhibits the secretion of FSH and LH; this means that the measurement of reproductive hormones in the serum may reflect testicular function, at least to some extent (Bhale & Mahat, 2013; Kauppila et al, 2010; Merino et al, 1999). In addition, T can affect sperm production by acting through androgen binding protein to chromatin in germ cells.…”

Section: Discussionmentioning

confidence: 99%

Correlation between serum levels of reproductive hormones and testicular spermatogenic function in men with azoospermia

Liu¹,

Wang²,

Zhang³

et al. 2022

Andrologia

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To investigate the serum levels of reproductive hormones in men with azoospermia and explore the correlation between abnormal reproductive hormones and the results of testicular biopsy and seminiferous extraction. The serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone (T), and pituitary prolactin (PRL), were measured by Radio immunoassay. Testicular biopsy was used to determine whether patient's had spermatozoa. Spearman's correlation analysis was used to analyse the correlation between LH, FSH, testicular volume, and spermatogenic function. Receiver operator characteristic (ROC) curves were used to evaluate the efficacy and significance of LH and FSH for the detection of spermatozoa and copy number variation sequencing (CNV‐seq). Compared with the control group, the serum levels of FSH and LH in the azoospermia group were significantly up‐regulated (p < 0.001). Prolactin (PRL) and testosterone levels did not differ significantly between the two groups (p > 0.05). The serum levels of FSH and LH were negatively correlated with testicular spermatogenic function and testicular volume. The areas under the ROC curves for determining FSH and LH potency by testicular biopsy with or without spermatozoa were 0.640 and 0.622, respectively. The areas under the ROC curves for the potency of FSH and LH, as judged by CNV detection results, were 0.523 and 0.534, respectively. Serum levels of FSH and LH are associated with azoospermia and may be of predictive significance in the clinical setting for the acquisition of spermatozoa by testicular biopsy.

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Relationship Between Hormone Levels and Testicular Biopsies of Azoospermic Men

Cited by 6 publications

References 26 publications

Alteration of sperm parameters and reproductive hormones in Swiss mice via oxidative stress after co‐exposure to titanium dioxide and zinc oxide nanoparticles

Alteration of sperm parameters and reproductive hormones in Swiss mice via oxidative stress after co‐exposure to titanium dioxide and zinc oxide nanoparticles

Echis ocellatus Venom-Induced Reproductive Pathologies in Rat Model; Roles of Oxidative Stress and Pro-Inflammatory Cytokines

Correlation between serum levels of reproductive hormones and testicular spermatogenic function in men with azoospermia

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