Relationship between hypothalamic–pituitary–adrenal axis dysregulation and insulin resistance in elderly patients with depression

Yokoyama, Katsutoshi; Yamada, Takeshi; Mitani, Hiroaki; Yamada, Sayaka; Pu, Shenghong; Yamanashi, Takehiko; Matsumura, Hiroshi; Nakagome, Kazuyuki; Kaneko, Koichi

doi:10.1016/j.psychres.2015.01.026

Cited by 31 publications

(17 citation statements)

References 35 publications

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“…A study of 4,333 middle-aged Japanese men suggested that depressive symptom were related to accumulation of visceral adipose, not subcutaneous adipose (Yamamoto et al, 2016). Potential mechanisms underlying these associations include hypothalamic-pituitary-adrenal axis (HPA-axis) dysregulation with hyper-cortisolemia (Yokoyama et al, 2015), inflammation (Miller et al, 2002), and the influences of lifestyle and behaviors (Lovell et al, 2014). …”

Section: Discussionmentioning

confidence: 99%

Adiposity is inversely associated with hippocampal volume in African Americans and European Americans with diabetes

Hsu

Yuan

Bowden

et al. 2016

Journal of Diabetes and its Complications

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Aims To assess associations between body mass index (BMI), waist circumference (WC), and computed tomography-determined volumes of pericardial, visceral, and subcutaneous adipose tissue with magnetic resonance imaging-(MRI) based cerebral structure and cognitive performance in individuals with type 2 diabetes (T2D). Methods This study was performed in 348 African Americans (AAs) and 256 European Americans (EAs) with T2D. Associations between adiposity measures with cerebral volumes of white matter (WMV), gray matter (GMV), white matter lesions, hippocampal GMV, and hippocampal WMV, cognitive performance and depression were examined using marginal models incorporating generalized estimating equations. All models were adjusted for age, sex, education, smoking, HbA1c, hypertension, statins, cardiovascular disease, MRI scanner (MRI outcomes only), and time between scans; some neuroimaging measures were additionally adjusted for intracranial volume. Results Participants were 59.9% female with mean (SD) age 57.7(9.3) years, diabetes duration 9.6(6.8) years, and HbA1c 7.8(1.9) %. In AAs, inverse associations were detected between hippocampal GMV and both BMI (β [95% CI] −0.18 [−0.30, −0.07], p=0.0018) and WC (−0.23 [−0.35, −0.12], p=0.0001). In the full bi-ethnic sample, inverse associations were detected between hippocampal WMV and WC (p<0.0001). Positive relationships were observed between BMI (p=0.0007) and WC (p<0.0001) with depression in EAs. Conclusions In patients with T2D, adiposity is inversely associated with hippocampal gray and white matter volumes.

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Section: Discussionmentioning

confidence: 99%

Adiposity is inversely associated with hippocampal volume in African Americans and European Americans with diabetes

Hsu

Yuan

Bowden

et al. 2016

Journal of Diabetes and its Complications

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“…The neuroendocrine immune network, especially in the hypothalamic-pituitary-adrenal axis (HPA), is closely associated with T2DM. Glucocorticoid secreted by the HPA axis adversely regulates blood glucose homeostasis by disrupting the insulin signaling pathway and glucose metabolism [60]. Glucocorticoids increase blood glucose level by stimulating the gluconeogenesis of the liver and inhibiting glucose uptake by tissues.…”

Section: Role Of Nlrp3 Inflammasome In Dmmentioning

confidence: 99%

P2X7 receptor mediates NLRP3 inflammasome activation in depression and diabetes

Wang

Gao

et al. 2020

Cell Biosci

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The increasing prevalence of depression and diabetes mellitus has become a major public health problem worldwide. Studies have shown that people with diabetes are at a high risk of being diagnosed with depression, and diabetes complicates depression treatment by promoting the deterioration of glycemic control, reducing self-care ability and quality of life, and causing severe functional disability and early mortality. Moreover, health deterioration dramatically increases the financial cost of social and health care system. Thus, how to treat depression, diabetes, and diabetes complicated by depression has become one of the world's urgent concerns. The activation of nod-like receptor family pyrin domain containing 3 (NLRP3) is closely related to mental illness. This finding provides a new perspective for studying depression. NLRP3 plays an important role in the development of diabetes. In this review, we elaborate the definition and epidemiology of depression, diabetes, and diabetic depression and introduce the functional characteristics of an NLRP3 inflammasome and upstream P2X7 receptor. Moreover, related research on NLRP3 inflammasomes and P2X7 receptors is summarized and used as a reference for confirming that the excessive activation of P2X7-NLRP3 leads to the increased release of inflammatory cytokines, such as IL-1β, in depression and diabetes. We provide insights into the P2X7-NLRP3-IL-1β pathway as an important pathological mechanism and novel therapeutic target in diabetes and depression. Given that the P2X7-NLRP3-IL-1β pathway may play an important role in diabetes confounded by comorbid depression, the possibility of intervention with baicalin is proposed.

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“…Chronic stress results in the dysregulation of hypothalamic-pituitary-adrenal (HPA) axis, which maybe one of the factors to MDD 17, 18 . The HPA axis, includes a feedback loop composed of the hypothalamus, pituitary and adrenal glands.…”

Section: Introductionmentioning

confidence: 99%

Puerarin ameliorated the behavioral deficits induced by chronic stress in rats

Qiu

Zhang

Zhong

et al. 2017

Sci Rep

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The present study aimed to investigate the mechanisms underlying the antidepressant-like effects of puerarin via the chronic unpredictable stress (CUS) procedure in rats. Similar to Sertraline (Ser), Chronic treatment of puerarin (60 and 120 mg/kg, i.g) elicited the antidepressant-like effects by reversing the decreased sucrose preference in sucrose preference test (SPT), by blocking the increased latency to feed in novelty-suppressed feeding test (NSFT) and the increased immobility time in forced swimming test (FST) without affecting locomotor activity. However, acute puerarin treatment did not ameliorate the antidepressant- and anxiolytic- like effects in FST and NSFT, respectively. In addition, enzyme linked immunosorbent assay (ELISA) and high performance liquid chromatography-electrochemical detection (HPLC-ECD) showed that chronic treatment of puerarin (60 and 120 mg/kg, i.g) reversed the decreased levels of progesterone, allopregnanolone, serotonin (5-HT) and 5-Hydroxyindoleacetic acid (5-HIAA) in prefrontal cortex and hippocampus of post-CUS rats. Furthermore, puerarin (60 and 120 mg/kg, i.g) blocked the increased corticotropin releasing hormone (CRH), corticosterone (Cort) and adrenocorticotropic hormone (ACTH). Collectively, repeated administration of puerarin alleviated the behavioral deficits induced by chronic stress which was associated with the biosynthesis of neurosteroids, normalization of serotonergic system and preventing HPA axis dysfunction.

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Relationship between hypothalamic–pituitary–adrenal axis dysregulation and insulin resistance in elderly patients with depression

Cited by 31 publications

References 35 publications

Adiposity is inversely associated with hippocampal volume in African Americans and European Americans with diabetes

Adiposity is inversely associated with hippocampal volume in African Americans and European Americans with diabetes

P2X7 receptor mediates NLRP3 inflammasome activation in depression and diabetes

Puerarin ameliorated the behavioral deficits induced by chronic stress in rats

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