Relationship between <i>AGT</i> rs2493132 polymorphism and the risk of coronary artery disease in patients with NAFLD in the Chinese Han population

Dong, Mingjie; Liu, Shousheng; Wang, Mengke; Wang, Yifen; Xin, Yongning; Xuan, Shi‐Ying

doi:10.1177/03000605211019263

Cited by 3 publications

(2 citation statements)

References 37 publications

(61 reference statements)

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“…CHD is a complex polygenic genetic disease affected by genetic factors. At present, several gene SNPs have been found to be associated with CHD risk, such as UTS2 (Ser89Asn) [ 18 ], CDKN2B-AS1 (rs10738606) [ 1 ], GLUT4 (rs5418) [ 19 ], CYP11B1 (rs4534, rs6410 and rs5283) [ 20 ], CYP24A1 (rs6068816 and rs2296241) [ 21 ] and AGT (rs2493132) [ 22 ]. Considering that the connection of CYP4V2 polymorphisms with CHD risk has not been reported, five SNPs (rs1398007, rs13146272, rs3736455, rs1053094 and rs56413992) in CYP4V2 gene were eventually genotyped in this study and their association with CHD risk were explored.…”

Section: Discussionmentioning

confidence: 99%

CYP4V2 rs56413992 C > T was associated with the risk of coronary heart disease in the Chinese Han population: a case–control study

Huang,

Ma,

et al. 2023

BMC Med Genomics

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Purpose The research aimed to detect the association between single nucleotide polymorphisms (SNPs) in CYP4V2 gene and coronary heart disease (CHD) risk. Methods This case–control study included 487 CHD subjects and 487 healthy individuals. Logistic regression was performed to analyze the connection between five SNPs in CYP4V2 (rs1398007, rs13146272, rs3736455, rs1053094, and rs56413992) and CHD risk, and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the connection. Results As a result, we found that rs56413992 T allele (OR = 1.36, 95% CI = 1.09–1.70, p = 0.007) and CT genotype (OR = 1.40, 95% CI = 1.06–1.83, p = 0.017) were significantly associated with an increased risk of CHD in the overall analysis. Precisely, rs56413992 was linked to an elevated risk of CHD in people aged > 60, males, smokers and drinkers. The study also indicated that rs1398007 was linked to an increased CHD risk in drinkers. In addition, rs1053094 was correlated with a decreased risk of CHD complicated with diabetes mellitus (DM), and rs1398007 was correlated with a decreased risk of CHD complicated with hypertension (HTN). Conclusion This study was the first to experimentally demonstrate that CYP4V2 rs56413992 was associated with the risk of CHD, which will provide a certain reference for revealing the pathogenesis of CHD.

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Section: Discussionmentioning

confidence: 99%

CYP4V2 rs56413992 C > T was associated with the risk of coronary heart disease in the Chinese Han population: a case–control study

Huang,

Ma,

et al. 2023

BMC Med Genomics

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“…Other newly identified gene polymorphisms apparently involved in the NAFLD–CAD relationship are represented by: adiponectin rs266729 [ 118 ], adiponectin-encoding gene (ADIPOQ), apolipoprotein C3 (APOC3), leptin receptor (LEPR), peroxisome proliferator activated receptors (PPAR), tumor necrosis factor-alpha (TNF-α), microsomal triglyceride transfer protein (MTTP), and manganese superoxide dismutase (MnSOD) [ 105 , 119 ]. The angiotensin (AGT) rs2493132 genotype displayed a significantly increased risk of developing CAD in a Chinese Han population with NAFLD [ 120 ]. Rab18 gene expression seems to be linked to increased adiposity and lipotoxicity [ 121 ].…”

Section: Potential Pathogenic Links Between Nafld and Cadmentioning

confidence: 99%

New Insights into Non-Alcoholic Fatty Liver Disease and Coronary Artery Disease: The Liver-Heart Axis

Cazac

Lǎcǎtusu

Mihai

et al. 2022

Life

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Non-alcoholic fatty liver disease (NAFLD) represents the hepatic expression of the metabolic syndrome and is the most prevalent liver disease. NAFLD is associated with liver-related and extrahepatic morbi-mortality. Among extrahepatic complications, cardiovascular disease (CVD) is the primary cause of mortality in patients with NAFLD. The most frequent clinical expression of CVD is the coronary artery disease (CAD). Epidemiological data support a link between CAD and NAFLD, underlain by pathogenic factors, such as the exacerbation of insulin resistance, genetic phenotype, oxidative stress, atherogenic dyslipidemia, pro-inflammatory mediators, and gut microbiota. A thorough assessment of cardiovascular risk and identification of all forms of CVD, especially CAD, are needed in all patients with NAFLD regardless of their metabolic status. Therefore, this narrative review aims to examine the available data on CAD seen in patients with NAFLD, to outline the main directions undertaken by the CVD risk assessment and the multiple putative underlying mechanisms implicated in the relationship between CAD and NAFLD, and to raise awareness about this underestimated association between two major, frequent and severe diseases.

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Non-Alcoholic Fatty Liver Disease and Coronary Artery Disease: A Bidirectional Association Based on Endothelial Dysfunction

Ktenopoulos,

Sagris,

Gerogianni

et al. 2024

IJMS

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Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and is regarded as a liver manifestation of metabolic syndrome. It is linked to insulin resistance, obesity, and diabetes mellitus, all of which increase the risk of cardiovascular complications. Endothelial dysfunction (EnD) constitutes the main driver in the progression of atherosclerosis and coronary artery disease (CAD). Several pathophysiological alterations and molecular mechanisms are involved in the development of EnD in patients with NAFLD. Our aim is to examine the association of NAFLD and CAD with the parallel assessment of EnD, discussing the pathophysiological mechanisms and the genetic background that underpin this relationship. This review delves into the management of the condition, exploring potential clinical implications and available medical treatment options to facilitate the deployment of optimal treatment strategies for these patients.

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Relationship between AGT rs2493132 polymorphism and the risk of coronary artery disease in patients with NAFLD in the Chinese Han population

Cited by 3 publications

References 37 publications

CYP4V2 rs56413992 C > T was associated with the risk of coronary heart disease in the Chinese Han population: a case–control study

CYP4V2 rs56413992 C > T was associated with the risk of coronary heart disease in the Chinese Han population: a case–control study

New Insights into Non-Alcoholic Fatty Liver Disease and Coronary Artery Disease: The Liver-Heart Axis

Non-Alcoholic Fatty Liver Disease and Coronary Artery Disease: A Bidirectional Association Based on Endothelial Dysfunction

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