Relationship between <i>CYP11B2</i>-344T&gt;C polymorphsim and atrial fibrillation: A meta-analysis

Fu, Xiaodan; Ma, Xiangyu; Zhong, Li; Zhang, Song

doi:10.1177/1470320314553984

Cited by 6 publications

(6 citation statements)

References 22 publications

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“…The role of the CYP11B2-344C/T polymorphism in the risk of developing AF has been reported in Chinese populations (Li et al, 2012;Lu et al, 2015). Similarly, other studies have shown that the CYP11B2-344C/T polymorphism is associated with AF in patients with heart failure (Amir et al, 2008) and hypertension (Fu et al, 2015). By contrast, Sun et al (2011) reported a lack of any association between this polymorphism and AF in a Chinese population.…”

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confidence: 77%

“…Likewise, a study by Amir et al (2008) found a significant relationship between this polymorphism and clinical AF. In addition, research has revealed that the CYP11B2-344C/T polymorphism is associated with AF in Chinese patients with hypertension (Fu et al, 2015) and in African Americans with heart failure (Bress et al, 2013). However, previous work failed to confirm this association between the CYP11B2-344C/T polymorphism and the incidence of AF in Chinese patients (Hou et al, 2017;Zhang et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

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Contribution of the ACE (rs1799752) and CYP11B2 (rs1799998) Gene Polymorphisms to Atrial Fibrillation in the Tunisian Population

Gouissem

Midani

Soualmia

et al. 2021

Biological Research For Nursing

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Background: This study investigated the association of angiotensin–converting enzyme (ACE I/D) and aldosterone synthase (CYP11B2-344C/T) gene polymorphisms in the renin–angiotensin–aldosterone system (RAAS) with atrial fibrillation (AF) in the Tunisian population. Materials and Methods: The study population included 120 patients with AF and 123 age-matched controls. Genotyping of the I/D polymorphism in the ACE gene and the -344C/T polymorphism in the CYP11B2 gene was performed by polymerase chain reaction (PCR) and PCR-RFLP methods, respectively. Results: The genotype distribution of the ACE I/D and CYP11B2-344C/T polymorphisms was significantly different between AF patients and control participants ( p < 0.01 and p < 0.006 respectively). In addition, ACE I/D increased the risk of AF significantly by 3.41-fold for the DD genotype (OR = 3.41; 95% CI [1.39–8.34]; p < 0.007), and after adjusting for confounding factors (age, diabetes, hypertension, and dyslipidemia), the risk was higher (OR = 5.71; 95% CI [1.48–21.98]; p < 0.01). Likewise, the CYP11B2-344C/T polymorphism increased the incidence of AF for the TT genotype (OR = 3.66; 95% CI [1.62–8.27]; p < 0.002) and the CT genotype (OR = 2.68; 95% CI [1.22–5.86]; p < 0.01). After adjusting for confounding factors (age, diabetes, hypertension and dyslipidemia), the risk remained higher for the TT genotype (OR = 3.58; 95% CI [1.08–11.77]; p < 0.03). Furthermore, the haplotype–based association of the ACE I/D and CYP11B2-344C/T polymorphisms showed that the D-T haplotype increased the risk for AF. Conclusion: Our study suggests a significant association of the ACE (I/D) and CYP11B2-344C/T polymorphisms with AF in the Tunisian population.

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confidence: 77%

Section: Discussionmentioning

confidence: 99%

Contribution of the ACE (rs1799752) and CYP11B2 (rs1799998) Gene Polymorphisms to Atrial Fibrillation in the Tunisian Population

Gouissem

Midani

Soualmia

et al. 2021

Biological Research For Nursing

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“…To date, several meta-analyses of gene polymorphisms and AF susceptibility have been published and have identi ed associations, including chromosome 4q25 variants, CYP11B2 -344T>C, and mink S38G [40][41][42][43]. A growing number of studies have identi ed polymorphisms in both ZFHX3 and PRRX1, although they have not been reported through meta-analysis studies that could clarify their associations with AF susceptibility.…”

Section: Discussionmentioning

confidence: 99%

Association between ZFHX3 and PRR X1 polymorphisms and atrial fibrillation susceptibility

Wu¹,

Chu²,

Zhuang³

2021

Preprint

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Background Atrial fibrillation (AF) is a common, sustained cardiac arrhythmia. Recent studies have reported an association between ZFHX3/PRRX1 polymorphisms and AF. In this study, a meta-analysis was conducted to confirm these associations. Methods The PubMed, Embase, and Wanfang databases were searched, covering all publications before July 20, 2020. Results Overall, seven articles including 3,674 cases and 8,990 healthy controls for ZFHX3 rs2106261 and 1045 cases and 1407 controls for PRRX1 rs3903239 were included. The odds ratio (OR) [95% confidence interval (CI)] was used to assess the associations. Publication bias was calculated using Egger’s and Begg’s tests. We found that the ZFHX3 rs2106261 polymorphism increased AF risk in Asians (for example, allelic contrast: OR [95% CI]: 1.39 [1.31–1.47], P < 0.001). Similarly, strong associations were detected through stratified analysis using source of control and genotype methods (for example, allelic contrast: OR [95% CI]: 1.51 [1.38–1.64], P < 0.001 for HB; OR [95% CI]: 1.31 [1.21–1.41], P < 0.001 for PB; OR [95% CI]: 1.55 [1.33–1.80], P < 0.001 for TaqMan; OR [95% CI]: 1.31 [1.21–1.41], P < 0.001 for high-resolution melt). In contrast, an inverse relationship was observed between the PRRX1 rs3903239 polymorphism and AF risk (C-allele vs. T-allele: OR [95% CI]: 0.83 [0.77–0.99], P = 0.036; CT vs. TT: OR [95% CI]: 0.79 [0.67–0.94], P = 0.006). No obvious evidence of publication bias was observed. Conclusion In summary, our study suggests that the ZFHX3 rs2106261 and PRRX1 rs3903239 polymorphisms are associated with AF risk, and larger case-controls must be carried out to confirm the above conclusions.

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“…So far, several meta-analyses about gene polymorphisms and AF susceptibility have been published: such as chromosome 4q25 variants, CYP11B2 -344T>C, mink S38G, and so on [40][41][42][43]. A growing number of papers have pointed to polymorphisms from both ZFHX3 and PRRX1 genes.…”

Section: Discussionmentioning

confidence: 99%

Association Between ZFHX3 and PRRX1 Genes’ Two Common Polymorphisms and Atrial Fibrillation Susceptibility in Asians

Wu¹,

Chu²,

Zhuang³

2020

Preprint

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BackgroundOne of the common sustained cardiac arrhythmia disorders is atrial fibrillation (AF), nowadays, results concerning the associations between ZFHX3/PRRX1 genes and AF has been widely reported. A meta-analysis to confirm above associations is necessary to be carried out in time. MethodsThe PubMed, Embase and Wanfang databases were conducted for searching, covering all publications before 20th July, 2020. ResultsOverall, seven articles including 3,674 cases and 8,990 healthy controls about ZFHX3 rs2106261 and 1045 cases and 1407 controls for PRRX1 rs3903239 were included. Odds ratio (OR)[95% confidence interval (CI)] was applied to assess the associations. Publication bias was calculated by both Egger’s and Begg’s tests. After calculated, we found that ZFHX3 rs2106261 polymorphism potential increased AF risk in Asians (for example: allelic contrast: OR [95%CI]: 1.39[1.31-1.47], P < 0.001). Similarly, stratified analysis by source of control and genotype method, also increased associations were detected (for example: allelic contrast: OR[95%CI] = 1.51[1.38-1.64], P < 0.001 for HB; OR[95%CI]: 1.31[1.21-1.41], P < 0.001 for PB; OR[95%CI] = 1.55[1.33-1.80], P < 0.001 for TaqMan; OR[95%CI] = 1.31[1.21-1.41], P < 0.001 for HRM). On the other hand, decreased relationship was observed between PRRX1 rs3903239 polymorphism and AF risk (C-allele vs. T-allele: OR[95%CI] = 0.83[0.77-0.99], P = 0.036; CT vs. TT: OR[95%CI] = 0.79[0.67-0.94], P = 0.006). No obvious evidence of publication bias was found. ConclusionsIn summary, our study suggested that ZFHX3 rs2106261 and PRRX1 rs3903239 polymorphisms had positive associations with AF risk, more large case-controls must be carried out to confirm above conclusions.

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Relationship between CYP11B2-344T>C polymorphsim and atrial fibrillation: A meta-analysis

Abstract: Our pooled data suggest a significant association exists between CYP11B2-344T>C polymorphism and AF among hypertension populations.

Cited by 6 publications

References 22 publications

Contribution of the ACE (rs1799752) and CYP11B2 (rs1799998) Gene Polymorphisms to Atrial Fibrillation in the Tunisian Population

Contribution of the ACE (rs1799752) and CYP11B2 (rs1799998) Gene Polymorphisms to Atrial Fibrillation in the Tunisian Population

Association between ZFHX3 and PRR X1 polymorphisms and atrial fibrillation susceptibility

Association Between ZFHX3 and PRRX1 Genes’ Two Common Polymorphisms and Atrial Fibrillation Susceptibility in Asians

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