2021
DOI: 10.3389/fcvm.2021.714276
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Relationship Between Immunoinflammation and Coronary Physiology Evaluated by Quantitative Flow Ratio in Patients With Coronary Artery Disease

Abstract: Background: The association between coronary physiology and immunoinflammation has not been investigated. We performed a retrospective study using quantitative flow ratio (QFR) to evaluate the interaction between immunoinflammatory biomarkers and coronary physiology.Methods: A total of 172 patients with CAD who underwent coronary arteriography (CAG) and QFR were continuously enrolled from May 2020 to February 2021. As a quantitative indicator of coronary physiology, QFR can reflect the functional severity of c… Show more

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Cited by 7 publications
(4 citation statements)
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References 49 publications
(57 reference statements)
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“…Pathologically, increasing research has confirmed that the context of acute myocardial ischemia could trigger an organismal stress response, induce cardiac sympathetic hyperactivity and suppress vagal activity, subsequently leading to coronary constriction, especially culprit vessel vasoconstriction, thus accelerating focal ischemia and hypoxia and causing the deterioration of myocardial ischemia ( 34 , 39 ). In addition, previous clinical and basic research has shown that the vagus nerve of the ANS is involved in the regulation of the inflammatory response ( 40 , 41 ), and the potential link among the ANS, inflammation and coronary artery physiology was confirmed by our previous studies ( 42 , 43 ). Furthermore, our data confirmed that injured cardiac autonomic nerves in the setting of myocardial ischemia subsequently developed an elevated risk of MACEs after ACS.…”
Section: Discussionsupporting
confidence: 77%
“…Pathologically, increasing research has confirmed that the context of acute myocardial ischemia could trigger an organismal stress response, induce cardiac sympathetic hyperactivity and suppress vagal activity, subsequently leading to coronary constriction, especially culprit vessel vasoconstriction, thus accelerating focal ischemia and hypoxia and causing the deterioration of myocardial ischemia ( 34 , 39 ). In addition, previous clinical and basic research has shown that the vagus nerve of the ANS is involved in the regulation of the inflammatory response ( 40 , 41 ), and the potential link among the ANS, inflammation and coronary artery physiology was confirmed by our previous studies ( 42 , 43 ). Furthermore, our data confirmed that injured cardiac autonomic nerves in the setting of myocardial ischemia subsequently developed an elevated risk of MACEs after ACS.…”
Section: Discussionsupporting
confidence: 77%
“…Our results therefore support the hypothesis that imbalance in cardiac ANS may affect local hydrodynamic shear forces and lead to vulnerability of coronary lesions, and may therefore play a key role in the pathogenesis of acute coronary events. Interestingly, our previous studies showed a significant interaction between ANS and immune inflammation on coronary physiology evaluated by QFR ( 11 , 39 ). These findings support the incorporation of ANS imbalance for risk stratification of patients with CAD.…”
Section: Discussionmentioning
confidence: 92%
“…For example, it has been reported that plasma levels of IFNγ were similar in elderly (median age 65 years) patients with CAD and age-matched outpatients without cardiac diseases [ 22 ]. Furthermore, a recent study on patients with CAD revealed that a marker combination including high blood levels of IL-6 and IL-10, but not those of IFNγ, was significantly associated with decreased coronary hemodynamics and predicted functional coronary stenosis [ 23 ]. Also, during a 7-year follow-up of patients with stable CAD, IL-8 was the only cytokine predicting cardiovascular events independent of the other cytokines studied, i.e., IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, TNFα, granulocyte–macrophage colony stimulating factor, and IFNγ [ 24 ].…”
Section: Discussionmentioning
confidence: 99%