Relationship between Inflammation and Vasospastic Angina

Hung, Ming-Yow; Hung, Ming‐Jui

doi:10.3390/medicina59020318

Cited by 7 publications

(10 citation statements)

References 92 publications

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“…A 1-SD increase in the log-transformed value of CRP was associated with a remarkable 50% increase in coronary risk, and subjects in the highest quintile of the CRP distribution thus showed a 2.6-fold increase in their risk of a future coronary event [41]. Furthermore, local and systemic inflammation is gaining ground as a potential contributing mechanism in vasospastic angina [42], especially the inflammation associated with the perivascular adipose tissue [43]; CRP might be a useful biomarker in that direction.…”

Section: Discussionmentioning

confidence: 99%

Myocardial Perfusion Imaging and C-Reactive Protein in Myocardial Ischemia: A Retrospective Single-Center Study

Rammos,

Bechlioulis,

Kekiopoulou

et al. 2024

Life

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Background: Inflammation is an important mechanism in atherosclerosis and plaque formation. C-reactive protein (CRP) is a common inflammatory biomarker associated with the risk of coronary heart disease. We investigated the relationship of CRP with findings from myocardial perfusion imaging (MPI). Methods: In this retrospective study, 102 consecutive patients (mean age 71 years, 68% males) who underwent MPI (for diagnostic reasons or quantification of myocardial ischemia) and CRP determination (upper limit: 6 mg/L) within 1 month from MPI were included. The patients had no infection or recent acute coronary syndrome. Results: The median CRP level was 4 mg/L (2, 10) among the study population. Patients with raised CRP had higher summed stress score (SSS) (p = 0.006) and summed rest score (SRS) (p = 0.001) and higher risk for SSS > 3 (OR 9.25, 95% CI 2.03–42.13, p = 0.001) compared to those with low CRP. The association of SSS and SRS with CRP levels was more evident in patients over 70 years (p = 0.027 and p = 0.005, respectively). No significant difference in summed difference score was shown. The two groups had no difference in other risk factors (p > 0.05 for all comparisons). Conclusion: a high level of CRP was associated with the presence and extent of stress-induced myocardial ischemia in MPI.

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Section: Discussionmentioning

confidence: 99%

Myocardial Perfusion Imaging and C-Reactive Protein in Myocardial Ischemia: A Retrospective Single-Center Study

Rammos,

Bechlioulis,

Kekiopoulou

et al. 2024

Life

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“…Chronic low-grade inflammation and plasma levels of hs-CRP, a sensitive marker of inflammation, are also increased in patients with CAS compared with those of non-CAS patients [1]. The roles of elevated local and systemic inflammation have been increasingly recognized in vasospastic angina [5].…”

Section: Discussionmentioning

confidence: 99%

“…Local coronary inflammatory changes play a role in the early anatomical changes in the coronary arteries in CAS, which might induce subsequent functional changes in these arteries, which may induce CAS [5].…”

Section: Discussionmentioning

confidence: 99%

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Association of the interleukine-6 polymorphism with catheter-induced coronary artery spasm in Egyptians

Abdelaziz,

Mohamed,

Dwedar

et al. 2024

Coronary Artery Disease

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Background The role of coronary artery spasm (CAS) was extended beyond variant angina to ischemic heart disease in general, including effort angina, unstable angina, acute myocardial infarction (MI) and sudden death. It is difficult and cumbersome to examine CAS during coronary angiography. Risk factors for CAS include smoking and genetic polymorphisms. Aim We aimed to investigate the association of the interleukin-6 (IL-6) polymorphism with catheter-induced CAS in Egyptian patients who undergo coronary angiography. Methods This is a case–control study. Two hundred patients with chronic coronary artery disease who underwent elective coronary angiography were included in the study. Patients were divided into two groups: the non-CAS group (100 patients) and the CAS group (100 patients). The subjects were genotyped to the −572 C>G (rs 1800796) polymorphism of the IL-6 gene by PCR-restriction fragment length polymorphism. Results We found that patients with CAS have more risk factors for atherosclerosis compared to those without CAS. Smoking, the IL-6 GG genotype, and the G allele were independent risk factors for CAS. Conclusion We concluded that the GG genotype and G allele of the IL-6 gene are associated with CAS. Smoking, the GG genotype, and the G allele of the IL-6 gene are independent predictors of catheter-induced CAS.

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“…Lifestyle adjustments, such as stress management, smoking cessation, and adopting a low-fat diet, in addition to the use of beta-blockers and angiotensin-converting enzyme inhibitors (ACEI), are also integral components of these preventive strategies. [3,[9][10][11] Furthermore, the prevention of heart failure, diastolic dysfunction, or ventricular aneurysms is equally crucial, often necessitating invasive treatment approaches. [3,[9][10][11] To recommend the moderate alcohol consumption (1 gram/day), we considered the established benefits associated with alcohol intake, including the elevation of HDL-cholesterol levels [12][13][14][15][16][17][18][19][20][21], the influence on platelet adhesion [13] through the antioxidant effects of resveratrol and quercetin [13,14,19,22], and the reduction of fibrinogen levels, while enhancing the production of nitric oxide [22].…”

Section: Introductionmentioning

confidence: 99%

Assessing the Benefits of Lifestyle Influences on Cardiovascular Health After Acute Coronary Syndrome

Rus,

Ardelean,

Crisan

et al. 2023

Preprint

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Objective: The objective of our study was to explore the potential benefits of combining moderate alcohol consumption with regular vigorous physical activity on HDL-cholesterol levels and its potential positive impact on cardiovascular health. Material and method: The study comprised two groups: group A (102 patients) who consumed 1 gram of alcohol per day, specifically red wine, and increased their exercise levels in addition to their standard medical treatment, and group B (108 patients) who adhered only to their standard medical treatment. The patients were monitored for a year, during which various clinical parameters were observed. Results:Our study showed that moderate alcohol consumption, particularly red wine, along with increased physical activity levels, was associated with enhancements in exercise tolerance and elevated levels of HDL-cholesterol. Our findings suggest the efficacy of the intervention in improving lipid profiles, with the group that consumed alcohol as part of their treatment scheme, generally experiencing more pronounced positive effects. Statistically significant differences between groups in terms of angina evolution, AMI recurrence, or arrhythmias evolution were not found. However, there were important differences in terms of EF improvement and quality of life, with the alcohol consuming group displaying greater improvements in both aspects. Conclusions:In conclusion, our study emphasizes the potential benefits of combining moderate alcohol consumption, specifically red wine, with increased physical activity levels for improving exercise tolerance and enhancing HDL-cholesterol levels. However, further research and clinical trials are essential to fully understand the mechanisms and optimize the integration of these lifestyle elements for improved cardiovascular health outcomes.

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Relationship between Inflammation and Vasospastic Angina

Cited by 7 publications

References 92 publications

Myocardial Perfusion Imaging and C-Reactive Protein in Myocardial Ischemia: A Retrospective Single-Center Study

Myocardial Perfusion Imaging and C-Reactive Protein in Myocardial Ischemia: A Retrospective Single-Center Study

Association of the interleukine-6 polymorphism with catheter-induced coronary artery spasm in Egyptians

Assessing the Benefits of Lifestyle Influences on Cardiovascular Health After Acute Coronary Syndrome

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