Relationship between inflammatory cells level and longer duration of hypertension in Chinese community residents

Yi, Yue; Qu, Ting; Shi, Aibin; Pang, Zhixin; Zhao, Yuxin; Li, Pengcheng; Xie, Juan; Zhi, Xiufang; Zhu, Yun; Zhu, Hong

doi:10.1080/10641963.2022.2100411

Cited by 5 publications

(2 citation statements)

References 44 publications

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“…Maio et al ( 25 ) reported that high sensitivity-CRP (hs-CRP) was independently associated with heart failure in hypertensive patients (HR = 1.162, 95% CI = 1.072–1.259). Previous studies have shown that WBC and NLR significantly increased in hypertension patients, and the NLR kept increasing with the prolongation of the duration of hypertension ( 26 ). Similarly, a recent population-based study also indicated that NLR could be a predictor of renal damage in the hypertension population ( 27 ).…”

Section: Discussionmentioning

confidence: 91%

Inflammation index SIRI is associated with increased all-cause and cardiovascular mortality among patients with hypertension

Zhao

Dong

Qin

et al. 2023

Front. Cardiovasc. Med.

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BackgroundInflammation plays an essential role in the pathogenesis of hypertension. A novel inflammatory biomarker systemic inflammatory response index (SIRI) is related with all-cause and cardiovascular (CVD) mortality, while the role of SIRI in hypertension patients is unclear.MethodsA total of 21,506 participants with hypertension were recruited in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. SIRI was calculated as the neutrophil count * monocyte count/lymphocyte count. Hypertension was defined according to the examination of blood pressure, prescription, and self-reported physician diagnosis. Survival status was followed through 31 December 2019. The non-linear relationship was assessed using restricted cubic spline analysis. The association of all-cause mortality with SIRI was evaluated using the Kaplan–Meier curve and the weighted Cox regression analysis. The predictive abilities were assessed with Receiver operating curve.ResultsDuring 189,063 person-years of follow-up, 5,680 (26.41%) death events were documented, including 1,967 (9.15%) CVD related deaths. A J-shaped association was observed between SIRI and all-cause and CVD mortality. The Kaplan–Meier curve indicated the all-cause and CVD mortality risks were higher in high SIRI quartiles compared with lower SIRI quartiles. After adjusting for all covariates, the SIRI was positively associated with the all-mortality risk with HR = 1.19 (1.15, 1.22), and CVD mortality with HR = 1.19 (1.15, 1.24). The result was robust in subgroup analysis and sensitivity analysis.ConclusionElevated SIRI level is associated with increased all-cause and CVD mortality among patients with hypertension. SIRI is considered as a potential inflammatory biomarker in the clinical practice. Further large-scale cohort studies are required to confirm our findings.

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Section: Discussionmentioning

confidence: 91%

Inflammation index SIRI is associated with increased all-cause and cardiovascular mortality among patients with hypertension

Zhao

Dong

Qin

et al. 2023

Front. Cardiovasc. Med.

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“…Animal studies demonstrated elevated levels of inflammatory factors in the plasma and walls of blood vessels in hypertensive animals ( Murray et al., 2021 ). Epidemiological and clinical trials have shown that plasma inflammatory factor levels in hypertensive patients are significantly higher than those in people with normal blood pressure ( Yi et al., 2022 ). Atherosclerosis, a type of chronic inflammation of blood vessels, is linked to hypertension, with some studies suggesting that inflammation and hypertension can both influence each other.…”

Section: Probiotic Adjuvant Therapy For Hypertensionmentioning

confidence: 99%

Probiotics: functional food ingredients with the potential to reduce hypertension

Chen

Liang²,

Liu

et al. 2023

Front. Cell. Infect. Microbiol.

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Hypertension is an increasingly pressing public health concern across the globe. It can be triggered by a variety of factors such as age and diet, as well as the stress of modern life. The traditional treatment of hypertension includes calcium ion blockers, angiotensin II receptor inhibitors and β-receptor blockers, but these drugs have at least some side effects. Recent studies have revealed that intestinal flora plays a vital role in maintaining and promoting human health. This is due to the type and amount of probiotics present in the flora. Probiotics can reduce hypertension symptoms through four mechanisms: regulating vascular oxidative stress, producing short-chain fatty acids, restoring endothelial cell function, and reducing inflammation. It has been reported that certain functional foods, using probiotics as their raw material, can modify the composition of intestinal flora, thus regulating hypertension symptoms. Consequently, utilizing the probiotic function of probiotics in conjunction with the properties of functional foods to treat hypertension is a novel, side-effect-free treatment method. This study seeks to summarize the various factors that contribute to hypertension, the mechanism of probiotics in mitigating hypertension, and the fermented functional foods with probiotic strains, in order to provide a basis for the development of functional foods which utilize probiotics as their raw material and may have the potential to reduce hypertension.

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Hypomagnesemia is Associated with the Skull Computed Tomography Black Hole Sign in Patients with Spontaneous Intracerebral Hemorrhage

Shen,

Zhu,

Yan

et al. 2024

World Neurosurgery

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Relationship between inflammatory cells level and longer duration of hypertension in Chinese community residents

Cited by 5 publications

References 44 publications

Inflammation index SIRI is associated with increased all-cause and cardiovascular mortality among patients with hypertension

Inflammation index SIRI is associated with increased all-cause and cardiovascular mortality among patients with hypertension

Probiotics: functional food ingredients with the potential to reduce hypertension

Hypomagnesemia is Associated with the Skull Computed Tomography Black Hole Sign in Patients with Spontaneous Intracerebral Hemorrhage

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