Relationship between Inflammatory Markers and New Cardiovascular Events in Patients with Acute Myocardial Infarction Who Underwent Primary Angioplasty

Franca, Eluisa La; Caruso, Marco; Sansone, A; Iacona, Rosanna; Ajello, Laura; Mancuso, Dario; Castellano, F; Novo, Salvatore; Assennato, Pasquale

doi:10.5539/gjhs.v5n4p48

Cited by 4 publications

(6 citation statements)

References 28 publications

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“…CRP can represent a marker for a pro‐inflammatory state, as it affects cardiovascular risk 45, 46, 47. Although women appear to have higher CRP levels than men, both rise progressively with increasing waist circumference.…”

Section: Discussionmentioning

confidence: 99%

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Upper body fat predicts metabolic syndrome similarly in men and women

Grundy

Williams

Vega

2018

Eur J Clin Investigation

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BackgroundThe metabolic syndrome is a constellation of risk factors including dyslipidemia, dysglycemia, hypertension, a pro‐inflammatory state, and a prothrombotic state. All of these factors are accentuated by obesity. However, obesity can be defined by body mass index (BMI), percent body fat, or by body fat distribution. The latter consists of upper body fat (subcutaneous and visceral fat) and lower body fat (gluteofemoral fat). Waist circumference is a common surrogate marker for upper body fat.MethodsData from the National Health and Nutrition Examination Survey (NHANES) for the years 1999‐2006 was examined for associations of metabolic risk factors with percent body fat, waist circumference, and BMI.ResultsAssociations between absolute measures of waist circumference and risk factors were similiar for men and women. The similarities of associations between waist circumference and risk factors suggests that greater visceral fat in men does not accentuate the influence of upper body fat on risk factors.ConclusionsDifferent waist concumference values should not be used to define abdominal obesity in men and women.

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Section: Discussionmentioning

confidence: 99%

“…44 CRP can represent a marker for a pro-inflammatory state, as it affects cardiovascular risk. [45][46][47] Although women appear to have higher CRP levels than men, both rise progressively with increasing waist circumference. Other factors besides body fat must be in play to explain the higher CRP levels in women.…”

Section: Discussionmentioning

confidence: 99%

Upper body fat predicts metabolic syndrome similarly in men and women

Grundy

Williams

Vega

2018

Eur J Clin Investigation

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“…163–166 This correlation may be useful for early diagnosis of IHD because multiple biomarkers can be used to detect inflammation including high-sensitivity C-reactive protein (hs-CRP), interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor (TNF-α). In fact, some of these biomarkers have been used to aid in the diagnosis of IHD.…”

Section: How Women Experience Ischemic Heart Diseasementioning

confidence: 99%

“…In fact, some of these biomarkers have been used to aid in the diagnosis of IHD. 164,166,167 However, some of the biomarkers are not specific for IHD, which may limit their diagnostic usefulness. Also, the exact mechanism of how biomarkers function is not clear.…”

Section: How Women Experience Ischemic Heart Diseasementioning

confidence: 99%

Preventing and Experiencing Ischemic Heart Disease as a Woman: State of the Science

McSweeney¹,

Rosenfeld²,

Abel³

et al. 2016

Circulation

210

123

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“…Further independent risk factors for having pro-oxidant HDL could be identified. i) History of prior AMI, considering the pivotal role of inflammation in the development of dysfunctional AMI (26) and the persistent inflammatory state after AMI (38), it is not surprising that patients with prior AMI are more prone to develop dysfunctional HDL. This observation might at least partially explain why survivors of AMI remained at a significantly higher cardiovascular risk compared to the general population (39).…”

Section: Distelmaier Et Al Pro-oxidant Hdl In Ste-acsmentioning

confidence: 99%

Pro-oxidant HDL predicts poor outcome in patients with ST-elevation acute coronary syndrome

Distelmaier¹,

Schrutka²,

Seidl³

et al. 2015

Thromb Haemost

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Oxidative stress affects clinical outcome in patients with ST-elevation acute coronary syndrome (STE-ACS). Although high-density lipoprotein (HDL) particles are generally considered protective, deleterious properties of HDL have been observed in patients with acute myocardial infarction. Here, we analysed the association between pro-oxidant HDL and all-cause mortality in STE-ACS patients. We determined the antioxidant function of HDL in 247 prospectively enrolled patients undergoing primary percutaneous coronary intervention for STE-ACS. Patients were stratified as by a pro-oxidant serum HDL oxidant index (HOI≥ 1) or with an antioxidant serum HOI (HOL< 1) capacity. Multivariate regression analysis was used to relate HOI to survival. The median follow-up time was 23 months (IQR 14.4-40.0 months). Pro-oxidant HDL was observed in 44.1 % of STE-ACS patients and was independently associated with all-cause mortality with a hazard ratio of 3.30(95 %CI 1.50-7.27, p = 0.003). Mortality rates were higher in patients with baseline pro-oxidant HDL compared to patients with preserved HDL function at 30 days (11.9 % vs 2.2 %, p=0.002), and at 4 years (22.9 % vs 8.7 %, p=0.002). Elevated neutrophil counts were a strong and independent predictor for pro-oxidant HDL with an odds ratio per standard deviation of 1.50 (95 %CI 1.11-2.03, p=0.008), as was history of prior acute myocardial infarction, elevated triglycerides levels and reduced glomerular filtration rate. In conclusion, pro-oxidant HDL represents a strong and independent predictor of long-term as well as short-term all-cause mortality in STE-ACS patients. Elevated neutrophil counts predicted the presence of serum pro-oxidant HDL. The maintenance of HDL functions might be a promising therapeutic target in STE-ACS patients.

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Relationship between Inflammatory Markers and New Cardiovascular Events in Patients with Acute Myocardial Infarction Who Underwent Primary Angioplasty

Cited by 4 publications

References 28 publications

Upper body fat predicts metabolic syndrome similarly in men and women

Upper body fat predicts metabolic syndrome similarly in men and women

Preventing and Experiencing Ischemic Heart Disease as a Woman: State of the Science

Pro-oxidant HDL predicts poor outcome in patients with ST-elevation acute coronary syndrome

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