Relationship between instrumental activities of daily living and blood glucose control in elderly subjects with type 2 diabetes

Bossoni, Simonetta; Mazziotti, Gherardo; Gazzaruso, Carmine; Martinelli, Daniela; Orini, Stefania; Solerte, Sebastiano Bruno; Romanelli, Giuseppe; Giustina, Andrea

doi:10.1093/ageing/afm158

Cited by 32 publications

(26 citation statements)

References 27 publications

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“…Many studies have shown that the greater burden of traditional diabetes complications and comorbidities [9,11,26,27] and poor glycaemic control [11,28] could contribute to the higher risk for disability associated with diabetes. Additionally, non-traditional diabetes-related problems, such as cognitive impairment and sarcopenia [29][30][31], could also be the potential mechanisms that cause disability.…”

Section: Discussionmentioning

confidence: 99%

Burden of diabetes in Australia: life expectancy and disability-free life expectancy in adults with diabetes

et al. 2016

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Aims/hypothesis The aim of this work was to estimate the life expectancy (LE) and disability-free life expectancy (DFLE) for adults with and without diabetes. Methods The Chiang method and the adapted Sullivan method were used to estimate LE and DFLE by age and sex. Mortality data in 2011 were available from the National Diabetes Services Scheme for diabetes and from standard national mortality datasets for the general population. Data on prevalence of disability and severe or profound core activity limitation were derived from the 2012 Australian Survey of Disability, Ageing and Carers (SDAC). The definitions of disability used in the SDAC followed the International Classification of Functioning, Disability and Health. Data on diabetes prevalence were derived from the Australian Diabetes, Obesity and Lifestyle study. ResultsThe estimated LE and DFLE (with 95% uncertainty interval [UI]) at age 50 years were 30.2 (30.0, 30.4) and 12.7 (11.5, 13.7) years, respectively, for men with diabetes, and the estimates were 33.9 (33.6, 34.1) and 13.1 (12.3, 13.9) years, respectively, for women with diabetes. The estimated loss of LE associated with diabetes at age 50 years was 3.2 (3.0, 3.4) years for men and 3.1 (2.9, 3.4) years for women, as compared with their counterparts without diabetes. The corresponding estimated loss of DFLE was 8.2 (6.7, 9.7) years for men and 9.1 (7.9, 10.4) years for women. Women with diabetes spent a greater number of absolute years and a greater proportion of their life with disability as compared with men with diabetes and women without diabetes. The gains in LE and DFLE across the whole population at age 50 years after hypothetically eliminating diagnosed diabetes were 0.6 (0.5, 0.6) years and 1.8 (1.0, 2.8) years. Conclusions/interpretation In adults, diabetes results in a modest reduction in LE and a substantial reduction in DFLE. Efforts to identify the specific causes of disability and effective interventions are needed.

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Section: Discussionmentioning

confidence: 99%

Burden of diabetes in Australia: life expectancy and disability-free life expectancy in adults with diabetes

et al. 2016

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“…In fact, in the general population, it has been demonstrated that prevalent vertebral fractures, whether clinically apparent or not, may be associated with increased morbility and mortality [36,37]. This aspect may be particularly important in patients with acromegaly and coexistent diabetes mellitus, a frail subpopulation with decreased survival and impaired quality of life [38,39]. Previous studies suggested that the early correction of GH hypersecretion may prevent the occurrence of fragility fractures in patients with acromegaly [3,4].…”

Section: Discussionmentioning

confidence: 99%

Influence of diabetes mellitus on vertebral fractures in men with acromegaly

et al. 2011

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Acromegaly is frequently complicated by fragility vertebral fractures and diabetes mellitus. Since type 2 diabetes mellitus is a cause of secondary osteoporosis in the general population, in this cross-sectional study we aimed at investigating the association between diabetes mellitus and vertebral fractures in males with acromegaly. Fifty-seven patients (median age 47 years, range: 24-85) with active (21 cases) and controlled (36 cases) acromegaly and 57 control subjects were evaluated for bone mineral density (BMD) by DXA and vertebral fractures by a quantitative morphometric analysis. Diabetes mellitus was found in 18 patients and 18 control subjects. The prevalence of vertebral fractures was higher in acromegalic patients as compared with the control subjects (50.9 vs. 10.5%; χ(2): 21.8; P < 0.001). Acromegalic patients with fractures had serum IGF-I values significantly higher (P = 0.009), longer duration of active disease (P < 0.001) and higher prevalence of active acromegaly (P = 0.007) and diabetes mellitus (P = 0.04) as compared to patients who did not fracture. When acromegaly was active, the prevalence of vertebral fractures was high independently of the coexistent diabetes mellitus. On the contrary, when acromegaly was controlled the prevalence of vertebral fractures was significantly higher in patients with diabetes as compared to patients without diabetes (62.6 vs. 28.0%; P = 0.04). In both diabetic and non diabetic patients, vertebral fractures occurred independently of BMD. In conclusion, this study suggests that diabetes mellitus may be associated with an increased prevalence of vertebral fractures in males with acromegaly. However, this effect seems to be relatively attenuated in the presence of persistent GH hypersecretion.

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“…Age, sex, and diagnostic history of depression, hypertension, and diabetes were included as covariates in order to account for their known influence on ADLs. For instance, past work shows that patients with diabetes, hypertension, and/or depression are at increased risk for disability and decline in ADLs [17-19]. A hierarchical regression analysis was then performed to determine the predictive validity of the 3MS for 12-month total ADLs.…”

Section: Methodsmentioning

confidence: 99%

Reduced cognitive function predicts functional decline in patients with heart failure over 12 months

Alosco

Spitznagel

Cohen

et al. 2013

European Journal of Cardiovascular Nursing

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Background Impaired activities of daily living (ADL) are common in heart failure (HF) patients and contribute to the elevated mortality and hospitalization rates in this population. Cognitive impairment is also prevalent in HF, though its ability to predict functional decline over time is unknown. Aims This study examined the longitudinal pattern of activities of daily living in HF persons and whether reduced baseline cognitive status predicts functional decline in this population. Methods 110 persons with HF completed the Lawton-Brody Activities of Daily Living Scale and were administered the Modified Mini-Mental Status Examination (3MS) at baseline and a 12-month follow-up. Three composite scores were derived from the Lawton-Brody, including total, instrumental, and basic ADLs. Results HF patients reported high rates of baseline impairments in instrumental ADLs, including shopping, food preparation, housekeeping duties, laundry, among others. Repeated measures analyses showed significant declines in total and instrumental ADLs from baseline to the 12-month follow-up in HF (p < .05). Hierarchical regression analyses showed that poorer baseline performance on the 3MS predicted worse total ADL performance at 12-months (β = .15, p = .049), including greater dependence in shopping, driving, feeding, and physical ambulation (p < .05 for all). Conclusion The current results show that HF patients report significant functional decline over a 12-month period and brief cognitive tests can identify those patients at highest risk for decline. If replicated, such findings encourage the use of cognitive screening measures to identify HF patients most likely to require assistance with ADL tasks.

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Relationship between instrumental activities of daily living and blood glucose control in elderly subjects with type 2 diabetes

Cited by 32 publications

References 27 publications

Burden of diabetes in Australia: life expectancy and disability-free life expectancy in adults with diabetes

Burden of diabetes in Australia: life expectancy and disability-free life expectancy in adults with diabetes

Influence of diabetes mellitus on vertebral fractures in men with acromegaly

Reduced cognitive function predicts functional decline in patients with heart failure over 12 months

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