General nonlinear high odd-order differential equations with Lidstone–Euler boundary conditions of second type are treated both theoretically and computationally. First, the associated interpolation problem is considered. Then, a theorem of existence and uniqueness of the solution to the Lidstone–Euler second-type boundary value problem is given. Finally, for a numerical solution, two different approaches are illustrated and some numerical examples are included to demonstrate the validity and applicability of the proposed algorithms.