Relationship Between LAPTM4B Gene Polymorphism and Susceptibility of Malignant Melanoma in Chinese Patients

Abstract

Lysosomal-associated protein transmembrane 4 beta (LAPTM4B) is known as an oncogene associated with many human malignant tumors. There are two alleles of the gene, LAPTM4B*1 and LAPTM4B*2. Previous studies have shown that LAPTM4B polymorphism contributes to the risk of many cancers. This case-control study was to investigate the relationship between LAPTM4B gene polymorphism and susceptibility of malignant melanoma. The genotypes of LAPTM4B were determined in 617 control subjects and 220 patients with malignant melanoma by utilizing polymerase chain reaction based on specific primers. The genotypic distribution of LAPTM4B and Hardy–Weinberg equilibrium were analyzed by χ2 test. Odds ratio and 95% confidence interval was calculated by unconditional logistic regression. The distributions of LAPTM4B genotypes were significantly different between melanoma patients (45.9% for *1/1, 46.4% for *1/2 and 7.7 for *2/2) and controls (54.5% for *1/1, 39.9% for *1/2 and 5.7 for *2/2). LAPTM4B *1/2 and LAPTM4B *2/2 had a 1.396-fold and 1.619-fold higher risk for melanoma occurrence than *1/1, and subjects with LAPTM4B*2 have a 1.308-fold higher risk than LAPTM4B*1 carriers. No association between LAPTM4B genotypes and gender, age, subtype, Clark level of invasion, Breslow thickness, ulceration, clinical stage, and C-KIT, BRAF gene mutation status was observed. LAPTM4B*2 is associated with the high risk of malignant melanoma and carrying LAPTM4B *2 may be a susceptible factor to Chinese melanoma patients.

Association between LAPTM4B gene polymorphism and prostate cancer susceptibility in an Iranian population

“…14 Other studies showed no statistical differences between alleles for nasopharyngeal carcinoma, 29 lung cancer, 31 breast cancer, 30 rectal or esophageal cancers, 28 melanoma, 35 and pancreatic cancer. 36 A meta-analysis conducted by Xia et al 37 showed that LAPTM4B polymorphism is associated with an increased risk of cancer in the Chinese Han population.…”

LAPTM4B: an oncogene in various solid tumors and its functions

“…Previous studies have shown that LAPTM4B polymorphisms were related to susceptibility to HCC, 18, 19 breast cancer, 20, 21, 22 non-small lung cancer, 23 gastric cancer, 24 cervical cancer, 25 endometrial carcinoma, 26 colorectal cancer, 27 lymphoma, 28 gallbladder carcinoma, 29 ovarian carcinoma 30 and malignant melanoma, 31 but not to squamous cell carcinomas such as esophageal carcinoma, rectum carcinoma 27 and nasopharyngeal carcinoma. 32 Lately, a meta-analysis in Chinese Han population revealed that LAPTM4B allele *2 carriers exhibited a higher cancer risk compared with allele *1 homozygotes (for *1/2, odds ratio= 1.55, 95% confidence interval 1.367–1.758; for *2/2, odds ratio=2.093, 95% confidence interval 1.666–2.629; for *1/2 + *2/2, odds ratio=1.806, 95% confidence interval 1.527–2.137).…”

The Transcription Factor AP4 Promotes Oncogenic Phenotypes and Cisplatin Resistance by Regulating LAPTM4B Expression

“…Allele *1 contains only one copy of a 19-bp sequence at the 5'UTR in the first exon, whereas the sequence in allele *2 is duplicated and tandemly repeated [14]. Previous study showed that LAPTM4B *2/2-type allele was significantly associated with the susceptibility of various adenocarcinoma including breast cancer [15][16][17], HCC [18,19], non-small lung cancer [20], gastric cancer [21], cervical cancer [22], colorectal cancer [23], lymphoma [24], gallbladder carcinoma [25], ovarian carcinoma [26] and malignant melanoma [27]. Therefore, we hypothesized that if there are some specific transcription factors binding to the LAPTM4B polymorphism region which play important roles in regulating LAPTM4B expression.…”