Relationship Between Left Atrial Volume and Atrial Fibrillation Following Coronary Artery Bypass Grafting

Nardi, Federico; Diena, Marco; Caimmi, Philippe Primo; Iraghi, Gabriele; Lazzero, Maurizio; Cerin, Giorgio; Rossi, Lídia Aparecida; Bongo, Angelo Sante; Cernigliaro, C; Lupi, Alessandro

doi:10.1111/j.1540-8191.2011.01373.x

Cited by 22 publications

(14 citation statements)

References 28 publications

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“…6 We noted an overall POAF incidence of 36.3%, with an early POAF occurrence of 27%: the most unexpected finding was an MT-POAF occurrence of lated to left atrial (LA) dimensions, 31 and LA dilatation may provide the substrate for the development of AF. Osranek et al showed that LA volume >32 ml/m 2 and age>65 years are predictors of increased incidence of early POAF in CABG patients; 32 the predictive value of LA volume was confirmed by Nardi et al 33 Nevertheless these authors did not report on body surface area or BMI differences between patients experiencing POAF or not. Echocardiographic evaluation of atrial dimensions, LV mass, and diastolic function were not standardized in the present study, so we cannot investigate the association between obesity, LV/LA morphological changes and subsequent AF.…”

Section: 56mentioning

confidence: 77%

Atrial Fibrillation at Mid-Term After Bioprosthetic Aortic Valve Replacement

Tosello¹,

Florens

Caruba

et al. 2014

Circ J

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Section: 56mentioning

confidence: 77%

Atrial Fibrillation at Mid-Term After Bioprosthetic Aortic Valve Replacement

Tosello¹,

Florens

Caruba

et al. 2014

Circ J

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“…What is known however is that POAF has some pro-arrhythmic mechanisms in common with other forms of AF as supported by data demonstrating that patients who develop POAF have a degree of structural remodelling evident by a larger left atrium, a tendency towards having larger left atrial appendage dimension, and lower left atrial ejection fraction. Additionally, those patients tend A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 7 to have increased atrial conduit function, and evidence of left ventricular diastolic relaxation impairment compared to those without AF (Aytemir, Aksoyek, Ozer, Aslamaci, & Oto, 1999;Ferro, et al, 2009;Leung, Bellows, & Schiller, 2004;Maesen, et al, 2012;Nakai, et al, 2002;Nardi, et al, 2012). Other abnormalities that have been associated with increased incidence of POAF include high pre-operative levels of cholesterol (Aydin, et al, 2014).…”

Section: Introductionmentioning

confidence: 93%

Inflammation, oxidative stress and postoperative atrial fibrillation in cardiac surgery

Zakkar

Ascione

James

et al. 2015

Pharmacology & Therapeutics

191

129

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Postoperative atrial fibrillation (POAF) is a common complication of cardiac surgery that occurs in up to 60% of patients. POAF is associated with increased risk of cardiovascular mortality, stroke and other arrhythmias that can impact on early and long term clinical outcomes and health economics. Many factors such as disease-induced cardiac remodelling, operative trauma, changes in atrial pressure and chemical stimulation and reflex sympathetic/parasympathetic activation have been implicated in the development of POAF. There is mounting evidence to support a major role for inflammation and oxidative stress in the pathogenesis of POAF. Both are consequences of using cardiopulmonary bypass and reperfusion following ischaemic cardioplegic arrest. Subsequently, several anti-inflammatory and antioxidant drugs have been tested in an attempt to reduce the incidence of POAF. However, prevention remains suboptimal and thus far none of the tested drugs has provided sufficient efficacy to be widely introduced in clinical practice. A better understanding of the cellular and molecular mechanisms responsible for the onset and persistence of POAF is needed to develop more effective prediction and interventions.

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“…A prior study stated that incidence of post-CABG Af was associated with preoperatively higher LA volumes lower LV EF. However, this study included patients with preoperative LA anteroposterior diameters measuring >40 mm and LV EF <40% [19]. We hypothesized that Af is more common among patients undergoing on-pump CABG and it is still the commonest arrhythmia encountered after CABG as illustrated through our work.…”

Section: Postoperativementioning

confidence: 96%

Postoperative Tachyarrhythmias: On-Pump versus Off-Pump Coronary Artery Bypass Grafting

Shehata

AbdElhalim

Hanna

et al. 2014

ISRN Vascular Medicine

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Objective. Tachyarrhythmias, after coronary artery bypass graft (CABG) surgery, develop in 11%–40% of patients. Surgery technique (on-pump or off-pump) might affect incidence of post-CABG tachyarrhythmias. Methods. The study included 60 patients undergoing CABG (≥2 grafts) with left ventricle ejection fraction (LV EF) >40%. Patients were divided into two groups equally: group A (on-pump) and group B (off-pump). Patients were subjected to electrocardiographic monitoring (7 days postoperatively), transthoracic echocardiography, with recording of surgical details and complications. Results. Data collected between December 2012 and May 2013 showed no significant difference between two groups regarding incidence of postoperative tachyarrhythmias with statistically significant higher incidence of supraventricular tachycardia in group B (P<0.05) and a trend towards higher incidence of atrial fibrillation in group A. Patients who developed postoperative tachyarrhythmias in group A showed higher prevalence of family history of coronary artery disease and higher incidence of postoperative chest infections (P<0.05), while those in group B showed higher mean LV EF (pre- and postoperatively) (P<0.05). Data were statistically described in terms of mean ± standard deviation. Comparison of numerical and categorical variables was done using Student’s t- and Chi-square tests, respectively. Conclusion. Adopting off-pump CABG technique is not associated with less incidence of post-operative tachyarrhythmias, as compared to on-pump technique.

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Relationship Between Left Atrial Volume and Atrial Fibrillation Following Coronary Artery Bypass Grafting

Cited by 22 publications

References 28 publications

Atrial Fibrillation at Mid-Term After Bioprosthetic Aortic Valve Replacement

Atrial Fibrillation at Mid-Term After Bioprosthetic Aortic Valve Replacement

Inflammation, oxidative stress and postoperative atrial fibrillation in cardiac surgery

Postoperative Tachyarrhythmias: On-Pump versus Off-Pump Coronary Artery Bypass Grafting

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