Relationship between left ventricular function and wall motion synchrony in heart failure assessed by ECG-gated myocardial perfusion SPECT

Yamamoto, Akira; Takahashi, Naoto; Ishikawa, Masahiro; Abe, Kazuya; Kobayashi, Yuko; Tamai, Jin; Munakata, Kazuo

doi:10.1007/s12149-008-0172-x

Cited by 8 publications

(6 citation statements)

References 18 publications

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“…55 Takahashi et al 56 reported a “cardioGRAF” program that measured regional LV systolic/diastolic function and dyssynchrony. It has been shown using cardioGRAF that LV function correlated with wall motion synchrony, 57 and baseline LV dyssynchrony and resynchronization achieved by CRT in a case of a 63-year-old male with non-ischemic cardiomyopathy and QRS duration of 112 ms. 58 …”

Section: Other Approaches To Assessing LV Dyssynchrony By Spect Mpimentioning

confidence: 99%

SPECT myocardial perfusion imaging for the assessment of left ventricular mechanical dyssynchrony

Chen

Garcia

Bax

et al. 2011

Journal of Nuclear Cardiology

112

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Phase analysis of gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is an evolving technique for measuring LV mechanical dyssynchrony. Since its inception in 2005, it has undergone considerable technical development and clinical evaluation. This article reviews the background, the technical and clinical characteristics, and evolving clinical applications of phase analysis of gated SPECT MPI in patients requiring cardiac resynchronization therapy or implantable cardioverter defibrillator therapy and in assessing LV diastolic dyssynchrony.

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Section: Other Approaches To Assessing LV Dyssynchrony By Spect Mpimentioning

confidence: 99%

SPECT myocardial perfusion imaging for the assessment of left ventricular mechanical dyssynchrony

Chen

Garcia

Bax

et al. 2011

Journal of Nuclear Cardiology

112

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“…However, the value of LVMD as a predictor of MACE of CAD patients still needs further study. The application of LVMD for CAD diagnosis was focused on the relationship between LVMD with coronary artery stenosis and myocardial perfusion defects in previous studies (9,10,24,25). LVMD has been suggested to be associated with occult atherosclerosis in patients with normal coronary angiography but with reversible perfusion defects (9) and subclinical atherosclerosis (24).…”

Section: Discussionmentioning

confidence: 99%

Incremental Value of Left Ventricular Mechanical Dyssynchrony Assessment by Nitrogen-13 Ammonia ECG-Gated PET in Patients With Coronary Artery Disease

Zheng

Liu

Zhang

et al. 2021

Front. Cardiovasc. Med.

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Background: Phase analysis is a technique used to assess left ventricular mechanical dyssynchrony (LVMD) in nuclear myocardial imaging. Previous studies have found an association between LVMD and myocardial ischemia. We aim to assess the potential diagnostic value of LVMD in terms of myocardial viability, and ability to predict major adverse cardiac events (MACE), using Nitrogen-13 ammonia ECG-gated positron emission tomography (gPET).Methods: Patients with coronary artery disease (CAD) who underwent Nitrogen-13 ammonia and Fluorine-18 FDG myocardial gPET were enrolled, and their gPET imaging data were retrospectively analyzed. Patients were followed up and major adverse cardiac events (MACE) were recorded. The Kruskal-Wallis test and Mann-Whitney U test were performed to compare LVMD parameters among the groups. Binary logistic regression analysis, receiver operating characteristic (ROC) curve analysis, and multiple stepwise analysis curves were applied to identify the relationship between LVMD parameters and myocardial viability. Kaplan–Meier survival curves and the log-rank test were used to look for differences in the incidence of MACE.Results: In total, 79 patients were enrolled and divided into three groups: Group 1 (patients with only viable myocardium, n = 7), Group 2 (patients with more viable myocardium than scar, n = 33), and Group 3 (patients with less viable myocardium than scar, n = 39). All LVMD parameters were significantly different among groups. The median values of systolic phase standard deviation (PSD), systolic phase histogram bandwidth (PHB), diastolic PSD, and diastolic PHB between Group 1 and Group 3, and Group 2 and Group 3 were significantly different. A diastolic PHB of 204.5° was the best cut-off value to predict the presence of myocardial scar. In multiple stepwise analysis models, diastolic PSD, ischemic extent, and New York Heart Association (NYHA) classification were independent predictive factors of viable myocardium and myocardial scar. The incidence of MACE in patients with diastolic PHB > 204.5° was 25.0%, higher than patients with diastolic PHB <204.5° (11.8%), but the difference was not significant.Conclusions: LVMD generated from Nitrogen-13 ammonia ECG-gated myocardial perfusion imaging had added diagnostic value for myocardial viability assessment in CAD patients. LVMD did not show a definite prognostic value.

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“…In addition, adverse effects of impaired LV synchrony on systolic and diastolic function indices were reported in different patient populations (24-26). However, to date, the determinants of impaired LV synchrony have not been figured out.…”

Section: Discussionmentioning

confidence: 99%

Relationship between epicardial fat tissue and left ventricular synchronicity: An observational study

Kırış

Kırış²,

Turan³

et al. 2015

Anatol J Cardiol

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Objective:Left ventricular (LV) systolic synchrony is defined as simultaneous activation of corresponding cardiac segments. Impaired synchrony has some adverse cardiovascular effects, such as LV dysfunction and impaired prognosis. Epicardial fat tissue (EFT) is visceral fat around the heart. Increased EFT thickness is associated with some disorders, such as LV dysfunction and hypertrophy, which play a role in the impairment of LV synchrony. However, the relationship between EFT and LV systolic synchrony has never been assessed. Thus, we aimed to evaluate the possible relationship between EFT and LV synchrony in this study.Methods:The study population consisted of 55 consecutive patients (mean age 46.4±13.4 years, 32 female) without bundle branch block (BBB). EFT and LV systolic synchrony were evaluated by transthoracic echocardiography using 2D and tissue Doppler imaging. Maximal difference (Ts-6) and standard deviation (Ts-SD-6) of time to peak systolic (Ts) myocardial tissue velocity obtained from 6 LV basal segments were used to assess LV synchrony. Multiple regression analysis was used to detect the independently related factors to LV synchrony.Results:The mean values of EFT thickness, Ts-6, and Ts-SD-6 were found to be 2.7±1.6 mm (ranging from 1-7 mm), 20.1±14.2 msec, and 7.7±5.6, respectively. EFT thickness also was independently associated with Ts-6 (β =0.332, p=0.01) and Ts-SD-6 (β =0.286, p=0.04).Conclusion:EFT thickness is associated with LV systolic synchrony in patients without BBB.

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Relationship between left ventricular function and wall motion synchrony in heart failure assessed by ECG-gated myocardial perfusion SPECT

Cited by 8 publications

References 18 publications

SPECT myocardial perfusion imaging for the assessment of left ventricular mechanical dyssynchrony

SPECT myocardial perfusion imaging for the assessment of left ventricular mechanical dyssynchrony

Incremental Value of Left Ventricular Mechanical Dyssynchrony Assessment by Nitrogen-13 Ammonia ECG-Gated PET in Patients With Coronary Artery Disease

Relationship between epicardial fat tissue and left ventricular synchronicity: An observational study

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