Relationship Between Left Ventricular Mass and Endothelium-Dependent Vasodilation in Never-Treated Hypertensive Patients

Perticone, Francesco; Maio, Raffaele; Ceravolo, Roberto; Cosco, Cristina; Cloro, C; Mattioli, Pier Luigi

doi:10.1161/01.cir.99.15.1991

Cited by 84 publications

(55 citation statements)

References 45 publications

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“…39,40 However, in the multivariate analysis adjusting for a number of relevant confounding factors, LV mass index emerged as a significant independent correlate of the FMD, with a moderately strong adjusted standardized correlation coefficient. This was expected based on finding reported by Perticone et al, 41 who described lower forearm blood flow increase by acetycholine in patients with LVH vs those with normal LV mass. In addition, however, we showed that LV chamber and midwall systolic function were not significant correlates of FMD, which was not previously reported.…”

Section: Discussionsupporting

confidence: 75%

Relations of left ventricular mass and systolic function to endothelial function and coronary flow reserve in healthy, new discovered hypertensive subjects

et al. 2005

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Left ventricular hypertrophy (LVH) is prognostically relevant, associated with major cardiovascular risk factors and with atherosclerosis. However, whether LVH is independently associated with impaired coronary flow reserve (CFR) and with endothelial dysfunction is disputed. We assessed the relationship of LV mass and systolic function to CFR and endothelial function in new discovered never treated subjects with essential arterial hypertension, but without coronary artery disease or microalbuminuria. LVH, ejection fraction (EF) and stress-corrected midwall shortening (MWS, a measure of myocardial contractility) were assessed by echocardiography. CFR was assessed by single-photon emission computed tomography and dipyridamole infusion. Endothelial function was evaluated by assessing 1-min postischaemic flow-mediated dilatation of the brachial artery (FMD); nitroglycerine-mediated dilatation (NMD) of the same brachial artery was used as measure of nonendothelium-dependent vasodilatation. In approximately 1 year, we enrolled 21 subjects who met stringent inclusion criteria (47710 years old, 26.672.8 kg/m 2 , 78% men). Five patients showed LVH. Multivariate analyses showed a significant negative correlation of LV mass index with FMD (b ¼ À0.61, Po0.05) but not with NMD, neither with CFR. Stress-corrected MWS showed independent correlation with CFR (b ¼ 0.51, Po0.05). Thus, in clinically healthy, new discovered hypertensive subjects, never treated and mostly in the early stage of arterial hypertension, LVH can be associated with endothelial dysfunction while maximal dipyridamoledependent CFR may be preserved; nevertheless, a cardiac phenotype presenting with tendency to impaired myocardial contractility, assessed by stress-corrected MWS, showed association with lower CFR in the early stage of arterial hypertension.

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Section: Discussionsupporting

confidence: 75%

Relations of left ventricular mass and systolic function to endothelial function and coronary flow reserve in healthy, new discovered hypertensive subjects

et al. 2005

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“…Several groups of investigators have reported increased cardiovascular risk in patients with an abnormal vasomotor response to acetylcholine, an agonist for endothelial production of nitric oxide, in the coronary [20][21][22] or forearm circulations [23,24]. Impaired brachial artery flow-mediated dilation, as measured by ultrasound, is also associated with increased risk for cardiovascular events [25][26][27].…”

Section: Clinical Studies Of Endothelial Function and Their Clinical mentioning

confidence: 99%

Effects of Flavonoid-Containing Beverages and EGCG on Endothelial Function

Shenouda

Vita

2007

Journal of the American College of Nutrition

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Abnormalities of the vascular endothelium contribute to all stages of atherosclerosis from lesion development to clinical cardiovascular disease events. Recognized risk factors, including diabetes mellitus, hypertension, dyslipidemia, cigarette smoking, and sedentary lifestyle are associated with endothelial dysfunction. A variety of pharmacological and behavioral interventions have been shown to reverse endothelial dysfunction in patients with cardiovascular disease. A large number of epidemiological studies suggest that dietary factors, including increased intake of flavonoidcontaining foods and beverages, reduce cardiovascular risk, and recent studies have shown that such beverages have favorable effects on endothelial function. These studies have engendered interest in the development of dietary supplements or drugs that would allow for more convenient and higher dose administration of flavonoids and might prove useful for prevention or treatment of cardiovascular disease. In this paper, we will review the contribution of endothelial dysfunction to the pathogenesis and clinical expression of atherosclerosis and recent data linking flavonoid and EGCG consumption to improved endothelial function and reduced cardiovascular risk.

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“…[173][174][175] Indeed, in patients with essential hypertension, carotid wall thickening and left ventricular mass correlate with reduced endothelium-dependent vasodilation. 176,177 The ET system is activated in several but not all animal models of arterial hypertension. 171,[178][179][180][181][182][183][184][185][186][187] Correspondingly, ET plasma levels have been reported to be elevated in certain patients with essential hypertension, 188 but this is a subject to controversy.…”

Section: Endothelin and Endothelin Antagonists In Hypertensionmentioning

confidence: 99%

Working under pressure: the vascular endothelium in arterial hypertension

et al. 2000

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The vascular endothelium synthesizes and releases a spectrum of vasoactive substances like nitric oxide (NO) and endothelin (ET). In hypertension, the delicate balance of endothelium-derived factors is disturbed. ET acts as the natural counterpart to endothelium-derived NO, which exerts vasodilating, antithrombotic, and antiproliferative effects, and inhibits leukocyte-adhesion to the vascular wall. Besides its blood pressure rising effect also in man, ET induces vascular and myocardial hypertrophy, which are independent risk factors for cardiovascular morbidity and mortality. The derangement of endothelial function in hypertension is likely to be caused in part by genetic factors, but also due to elevated blood pressure itself. Due to its position between blood pressure and smooth muscle cells responsible for peripheral resistance, the endothelium is thought to be both target and mediator of arterial hypertension. Oxi-

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Relationship Between Left Ventricular Mass and Endothelium-Dependent Vasodilation in Never-Treated Hypertensive Patients

Abstract: Our data provide the first evidence that echocardiographic LVM in hypertensive patients is inversely related to FBF responses to the endothelium-dependent vasodilating agent ACh, but it is likely that both endothelium and LVM are damaged by hypertension.

Cited by 84 publications

References 45 publications

Relations of left ventricular mass and systolic function to endothelial function and coronary flow reserve in healthy, new discovered hypertensive subjects

Relations of left ventricular mass and systolic function to endothelial function and coronary flow reserve in healthy, new discovered hypertensive subjects

Effects of Flavonoid-Containing Beverages and EGCG on Endothelial Function

Working under pressure: the vascular endothelium in arterial hypertension

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