Relationship between left ventricular mass and heart sympathetic activity in male obese subjects

Amador-Licona, Norma; Encarnación, José de Jesús; Rodrı́guez, Leticia; Tello, Adolfo; López, Manuel; Guizar, Juan Manuel

doi:10.1016/j.arcmed.2004.05.003

Cited by 16 publications

(5 citation statements)

References 35 publications

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“…These results reinforce the fact that the elevated persistence of LVH in renal-graft recipients seems to be the result of many factors, such as augmented sympathetic activity [30], immunosuppressive agents [2], hypertension, donor type, and changes on body composition [31,32]. In a previous study by our group, systolic blood pressure levels, BMI, and LF/HF ratio were the most important determinants of LVM in obese adults and [33]. However, in the multiple regression analysis after RT, only baseline LVM and donor type were related to a decrease in LVM.…”

Section: Resultssupporting

confidence: 89%

Left ventricular mass and heart sympathetic activity after renal transplantation in children and young adults

et al. 2006

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Recent studies considered that an increase in sympathetic activity (SA) may be responsible for left ventricular hypertrophy (LVH). Before and after renal transplantation (RT), we evaluated changes on left ventricular mass (LVM) and SA in 40 end-stage renal disease patients between 8 and 35 years old. Hypertension (95.0% vs. 71.0%; p=0.005), use of combined antihypertensive drugs (57.5% vs. 30.0%; p=0.01), and LVH (77.5% vs. 52.5%; p=0.01) significantly decreased after RT whereas low-to-high frequency ratio (LF/HF), which represents SA, increased (3.1 vs. 5.3; p=0.0001). However, LVM regressors (with decrease on LVM index more than 20%) showed a trend of lower change on LF/HF ratio (1.6 vs. 2.4; p= 0.09) than nonregressors. Living-donor graft, baseline LVM, use of antihypertensive drugs, lower change on LF/HF ratio, and lower systolic blood pressure levels were associated with LVM regression in the simple correlation analysis. However, in the logistic regression analysis, only baseline LVM and donor type remained in the model (R(2)=0.35; p=0.0003). Thus, LVH decreased after RT and was related to baseline LVM and living-donor type. However, it is possible that the higher persistence of LVH after RT could be explained at least in part by increase in heart sympathetic activity and use of immunosuppressors.

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Section: Resultssupporting

confidence: 89%

Left ventricular mass and heart sympathetic activity after renal transplantation in children and young adults

et al. 2006

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“…Arterial stiffness is associated with sympathetic nervous system activity [29]. The sympathetic nervous system is more active in obese, than in young non-obese adult individuals [1]. Sympathetic nervous system activities increased after a 500-kcal test meal comprising 17.5 g of protein, 32.4 g of fat, and 50.1 g of carbohydrate [21].…”

Section: Variablementioning

confidence: 99%

Effects of Acute Aerobic Exercise on Arterial Stiffness Before and After Glucose Ingestion

2016

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The purpose of present study was to compare the acute effects of moderate-intensity aerobic exercise (65% peak oxygen uptake, 30 min) on arterial stiffness before and after glucose ingestion. 11 healthy young males completed 4 trials in random order. They started aerobic exercise at 90 min before (-90 min-EX), 60 min before (-60 min-EX), 30 min after (30 min-EX), and 60 min after (60 min-EX) the 75-g oral glucose tolerance test (OGTT). Aortic (carotid-femoral) and leg (femoral-ankle) pulse wave velocity (PWV), brachial and ankle blood pressure (BP), blood glucose (BG) and insulin levels were measured at 90 min (baseline) and 30 min before and at 30, 60 and 120 min after the 75-g OGTT. Aortic PWV and brachial systolic BP did not change from baseline after the 75-g OGTT in all trials. Leg PWV and ankle systolic BP increased from baseline after the 75-g OGTT in the -90, 30 and 60 min-EX, but not in the -60 min-EX. Levels of BG and insulin increased from baseline after the 75-g OGTT in all trials. These results suggest that the aerobic exercise most effectively suppresses the increase in peripheral arterial stiffness after glucose ingestion when implemented before glucose ingestion.

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“…22 These LV changes in obese subjects can be partially explained by the haemodynamic and heart autonomic changes that accompany obesity. 23,5 After treatment, systolic and diastolic blood pressure levels significantly decreased in both, losartan and spironolactone groups. As these drugs interfere in the reninangiotensin-aldosterone system, the results were expected.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] LVM is a predictor of cardiovascular morbidity and mortality independent or arterial hypertension and other traditional risk factors. 4 Myocardial hypertrophy is the result of chronic adaptation of the left ventricle to increased heart sympathetic activity, 5 and volume expansion linked to insulin resistance, salt intake, and through complex mechanisms that involve activation of the tissue renin-angiotensin system. 6,7 Heart sympathetic overactivity has been linked with the generation of ventricular arrhythmias and sudden death.…”

Section: Introductionmentioning

confidence: 99%

Effect of losartan and spironolactone on left ventricular mass and heart sympathetic activity in prehypertensive obese subjects: a 16-week randomized trial

et al. 2005

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Obesity has been shown to be associated with increased left ventricular mass (LVM) and heart sympathetic activity even in nonhypertensive subjects. These factors are predictors of cardiovascular morbidity and mortality independent of other traditional risk factors. We evaluated the effect of losartan and spironolactone on LVM and heart sympathetic activity in prehypertensive obese subjects. A 16-week blinded randomized trial was performed in middle-aged men selected from a Health Public program. Anthropometric and clinical variables were measured at baseline and after losartan (50 mg/day; n ¼ 25) or spironolactone (25 mg/day; n ¼ 25) treatment. Heart sympathetic activity was evaluated with 60-min electrocardiograph monitoring, and spectral analysis was carried out. LVM was measured by echocardiography according to Devereux and Reicheck's formula indexed for body height (m 2.7 ) to account for obesity. Anthropometric variables, systolic, and diastolic blood pressure levels decreased in both groups of treatment without statisticall difference between them. Losartan increased heart rate variability (from 70.0 to 82.3 ms; P ¼ 0.01), and decreased low frequency-high frequency index (from 6.6 to 4.9; P ¼ 0.001), and LVM (from 49.2 to 45.2 g; P ¼ 0.004). In the multiple regression analysis for factors associated with reduction in LVM; treatment with losartan, and decrease in SBP were the only factors included in the model (R 2 ¼ 0.60; P ¼ 0.003). To conclude losartan, but not spironolactone, decreased LVM and heart sympathetic overactivity in prehypertensive obese subjects after 16 weeks of treatment. Regression on LVM was associated with reduction on SBP levels.

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Relationship between left ventricular mass and heart sympathetic activity in male obese subjects

Cited by 16 publications

References 35 publications

Left ventricular mass and heart sympathetic activity after renal transplantation in children and young adults

Left ventricular mass and heart sympathetic activity after renal transplantation in children and young adults

Effects of Acute Aerobic Exercise on Arterial Stiffness Before and After Glucose Ingestion

Effect of losartan and spironolactone on left ventricular mass and heart sympathetic activity in prehypertensive obese subjects: a 16-week randomized trial

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