Relationship between leptin and oestrogens in healthy women

Mannucci, Edoardo; Ognibene, Agostino; Becorpi, Angelamaria; Cremasco, Francesco; Pellegrini, Sandra; Ottanelli, Serena; Rizzello, Salvatore Marco; Massi, Giambattista; Messeri, Gianni; Rotella, Carlo Maria

doi:10.1530/eje.0.1390198

Cited by 92 publications

(65 citation statements)

References 22 publications

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“…We found a statistically significant correlation between serum oestradiol and leptin when measurements from different time points were pooled together, which is in agreement with one earlier report (24) but not with others (25)(26)(27)(28). This weak positive correlation between serum leptin and oestradiol concentrations could not be reproduced when the percentage changes in these variables were used in the analysis.…”

Section: Discussionsupporting

confidence: 90%

Acute inhibition of oestrogen biosynthesis does not affect serum leptin levels in young men

Luukkaa

Rouru

Ahokoski

et al. 2000

European Journal of Endocrinology

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Objective: Leptin plays an important role in the regulation of reproduction. To explore the contribution of oestradiol to serum leptin levels in men, we measured the concentrations of serum leptin and insulin after inhibition of oestrogen biosynthesis by selective blockade of the aromatase enzyme. Design: The study had a double-blind parallel group design. Methods: The aromatase inhibitor, MPV 2213ad, was given to eight healthy male volunteers as a single dose of 100 mg. Eight men received placebo. Serum leptin and insulin were determined from blood samples collected at 0800 h, 1600 h and 2000 h both on the actual test day (day 0) and on the previous day (day ¹1), and from single blood samples taken in the morning of days 1, 2, 4 and 7. Changes in serum leptin were correlated with those seen in serum oestradiol, testosterone, LH, FSH, cortisol and aldosterone, which were determined earlier.Results: After the aromatase inhibitor administration, mean serum oestradiol concentration was reduced by 74% from the baseline compared with a 19% reduction in the placebo group (P for difference < 0.001), and returned to pre-treatment levels within four days. Despite marked changes in serum oestradiol and sustained elevations in serum testosterone, LH and FSH concentrations, serum leptin concentrations were similar in the group receiving the aromatase inhibitor and in the placebo group. We found a weak correlation between serum oestradiol and leptin, which could not be reproduced when the percentage changes in these variables were analysed. Conclusion: Marked short-term reduction in serum oestradiol concentration has no effect on serum leptin levels in young men.

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Section: Discussionsupporting

confidence: 90%

Acute inhibition of oestrogen biosynthesis does not affect serum leptin levels in young men

Luukkaa

Rouru

Ahokoski

et al. 2000

European Journal of Endocrinology

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“…Results published on serum leptin levels during the physiological menstrual cycle vary considerably. Some studies showed significant increase in the late follicular phase (9,10), and some did so on the day of the onset of the luteinising hormone (LH) surge (11,12). Other investigations described significant increase in serum leptin levels in the late luteal phase (13)(14)(15)(16)(17), and again others reported only small, not statistically significant variations during the menstrual cycle (18)(19)(20)(21).…”

Section: Introductionmentioning

confidence: 99%

Serum leptin and C-reactive protein levels in the physiological spontaneous menstrual cycle in reproductive age women

Wunder¹,

Yared²,

Bersinger³

et al. 2006

eur j endocrinol

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Objective: Only a few studies have investigated variations of different markers for inflammatory processes during the physiological menstrual cycle. The results are conflicting, particularly concerning the correlation between the marker leptin and steroid hormones. The aim of the study was to investigate the inflammatory markers C-reactive protein (CRP) and leptin in the serum of healthy, normally ovulating women and to correlate these with each other and with the hormones of the gonadal axis. A cycle-dependence of the markers studied would imply an exact timing of the blood sampling for clinical needs. Design: Observational study investigating the two inflammatory markers CRP and leptin in relation to the hormonal pattern of the gonadal axis during the normal cycle. Methods: Ovulatory cycles of 36 healthy, young, normo-androgenic women, having a normal body mass index were evaluated. Serum concentrations of leptin and CRP, as well as of follicle-stimulating hormone, luteinising hormone, 17b-oestradiol, progesterone, prolactin (PRL) and free testosterone were measured every 1-2 days during one full cycle. Results: Serum levels of leptin and CRP behaved differently during ovulatory cycles, with higher concentrations for leptin only during certain phases. Significant correlations were found in the follicular phase between leptin and PRL and leptin and free testosterone. Conclusions: Leptin levels change during the menstrual cycle. Leptin levels are more stable on cycle days 1-5 than later in the cycle. For precise cycle-independent measurements, these fluctuations have to be taken into account. There is no similar cyclic pattern for CRP.European Journal of Endocrinology 155 137-142

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“…During the menstrual cycle leptin levels increase in the follicular phase and decline in the luteal phase (Hardie et al 1997), suggesting a disproportional influence of estradiol elevation on leptin secretion (Mannuci et al 1998, Riad-Gabriel et al 1998. During IVF cycles, serum leptin rises in response to exogenous follicle-stimulating hormone (FSH) administration (Butzow et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Serum and follicular fluid leptin levels are correlated with human embryo quality

Anifandis¹,

Koutselini²,

Stefanidis³

et al. 2005

Reproduction

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This prospective study was undertaken to reassess the prognostic value of leptin during critical stages of in vitro fertilizationembryo transfer (IVF-ET) and address its role in the functional staging of assisted reproductive technologies at the level of embryo quality. Serum and follicular fluid samples of 100 selected women undergoing the long IVF-ET protocol were collected for leptin and embryo quality determination. The highest serum leptin concentration (52.11 6 4.27 ng/ml) was observed on ovum pick up day, while follicular fluid leptin was higher than all serum samples examined (62.59 6 5.73 ng/ml). Serum leptin above 59.48 6 7.6 ng/ml was associated with 'poor' embryo quality and above 56.87 6 5.52 ng/ml with pregnancy failure. Elevated leptin concentrations were associated with reduced ovarian stimulation and response, follicle maturation, embryo quality and pregnancy success. Our findings suggest that leptin modulates embryo quality and may serve as a sensitive marker of IVF outcome.

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Relationship between leptin and oestrogens in healthy women

Cited by 92 publications

References 22 publications

Acute inhibition of oestrogen biosynthesis does not affect serum leptin levels in young men

Acute inhibition of oestrogen biosynthesis does not affect serum leptin levels in young men

Serum leptin and C-reactive protein levels in the physiological spontaneous menstrual cycle in reproductive age women

Serum and follicular fluid leptin levels are correlated with human embryo quality

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