Relationship between level of forage intake, blood flow and oxygen consumption by splanchnic tissues of sheep fed a tropical grass forage

Hentz, Fernanda; Kozloski, Gilberto Vilmar; Zeni, Diego; Brun, Maurício Veloso; Stefanello, Simone

doi:10.1111/jpn.12519

Cited by 7 publications

(3 citation statements)

References 22 publications

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“…The ST contributes a high proportion of whole‐animal energy expenditure accounting for up to 50% of the total oxygen consumption (Huntington, ; Johnson, Johnson, & Baldwin, ). In the present study, by extrapolating the O 2 consumption to a 24‐hr period, and taking into account a heat equivalent of 4.89 kcal/L of O 2 uptake (Huntington & Tyrrell, ), the heat produced by liver and ST was on average 6 and 14 kcal/kg BW representing 16% and 38% of the ME intake, respectively, values in agreement with previews findings (El‐Sabagh, Goto, Sugino, Obitsu, & Taniguchi, ; Hentz, Kozloski, Zeni, Brun, & Stefanello, ). Moreover, glucose and urea synthesis are among the most energetically demanding processes in liver (McBride & Kelly, ).…”

Section: Discussionsupporting

confidence: 91%

Oxygen uptake and net flux of metabolites by splanchnic tissues of sheep in response to short‐term mesenteric infusion of nitrogenous compounds

Stefanello

Mezzomo

Zeni

et al. 2018

Animal Physiology Nutrition

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This study was conducted in an attempt to quantify the impact of N load on splanchnic tissues metabolism of sheep. The trial was conducted with four male sheep (45 ± 2.5 kg body weight (BW)) surgically implanted with chronic indwelling catheters into the portal, hepatic and mesenteric veins. Blood flow and metabolic flux through portal-drained viscera (PDV), liver and total splanchnic tissues (ST) were measured daily following a 4 × 4 Latin Square experimental design, where sheep were continually infused into the mesenteric vein with a physiological saline (0.15 m NaCl) solution during 90 min followed by the infusion, during more 120 min, of either solution: physiological saline (control), 0.250 mNH HCO , 0.250 m L-alanine or 0.125 m L-arginine, all of them infused at a rate of 1.5 ml/min to provide 375 μmol N/min. During the treatment infusion period, the net removal of ammonia N and the net production of urea N by liver were higher (p < .05) in NH HCO infused sheep Based on oxygen consumption, and on average of all treatments, the heat produced by liver and ST was on average 6 and 14 kcal/kg BW representing 16% and 38% of the metabolizable energy intake respectively. Linear relationships between variables indicated that gluconeogenesis and ureagenesis occurred concomitantly and both processes accounted for approximately 50% of total liver energy expenditure, two-thirds of it associated with gluconeogenesis. The results of the current study did not present clear evidence of the expected energy costs associated with ammonia N, alanine or arginine metabolism by liver. However, they indicated that gluconeogenesis is on average a more energy expensive process than ureagenesis.

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Section: Discussionsupporting

confidence: 91%

Oxygen uptake and net flux of metabolites by splanchnic tissues of sheep in response to short‐term mesenteric infusion of nitrogenous compounds

Stefanello

Mezzomo

Zeni

et al. 2018

Animal Physiology Nutrition

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“…The liver and kidneys have a central role in the metabolism of organic acids and dietary protein and may have hypertrophied to process the greater flow of these compounds in the body of the animals fed with cactus (Hentz et al 2016).…”

Section: Discussionmentioning

confidence: 99%

Spineless cactus associated with Tifton hay or sugarcane bagasse may replace corn silage in sheep diets

Ribeiro

Santos

Júnior

et al. 2017

Trop Anim Health Prod

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The effect of the replacement of corn silage with spineless cactus associated with Tifton 85 hay or sugarcane bagasse was evaluated on the performance, body weight components and sheep meat quality. Twenty-one Santa Inês male sheep with initial body weight of 22.9 ± 2.9 kg were used. They were confined in individual stalls for 74 days receiving the following diets: corn silage + concentrate (CS); spineless cactus + Tifton 85 hay + concentrate (TH); spineless cactus + sugarcane bagasse + concentrate (SB). After the feedlot period, the animals were slaughtered and their body components were weighed and sampled. Data were submitted to Tukey's test at 5% probability. The average daily gain (0.25 vs 0.14 kg), cold carcass weight (13.3 vs 13.7 kg), loin muscularity (0.6 vs 0.4 kg) and liver weight (0.7 vs. 0.5 kg) were higher (P < 0.05) for the TH diet when compared to that for the CS. The physical-chemical parameters of meat were not influenced (P > 0.05) by the treatments and presented about 20.1% of crude protein, 6.1% of crude fat and shear force of 2.0 kgf/cm. In complete diets for sheep, Tifton 85 hay associated with spineless cactus provides greater weight gain, cold carcass muscularity and organ weight when compared to those for animals fed with corn silage as exclusive roughage. Sugarcane bagasse associated with spineless cactus may replace corn silage in complete diets for sheep.

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“…However, it worth noting that despite improving the ratio of concentrate to forage (F: C) can increase the levels of weight gain and/or efficiency of gain, there may be a change in the metabolic state of animals [ 2 ]. Previous studies have reported that dietary nutrient levels such as F: C significantly affected animal metabolic activities [ 3 , 4 ]. Research has consistently shown that feeding a high concentrate diet in ruminants can lead to rapid fermentation and subsequent excessive organic acid accumulation.…”

Section: Introductionmentioning

confidence: 99%

Genome wide transcriptome analysis provides bases on hepatic lipid metabolism disorder affected by increased dietary grain ratio in fattening lambs

Gebeyew

et al. 2023

BMC Genomics

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Background The liver is a principal metabolic organ and has a major role in regulating lipid metabolism. With the development of rapidly fattening livestock in the modern breeding industry, the incidence of hepatic steatosis and accumulation in animals was significantly increased. However, the molecular mechanisms responsible for hepatic lipid metabolic disturbances in a high concentrate diet remain unclear. The objective of this study was to evaluate the effects of increasing concentrate level in a fattening lamb diet on biochemical indices, hepatic triglycerides (TG) concentration, and hepatic transcriptomic profiles. In the present study, 42 weaned lambs (about 3 ± 0.3 months old) were randomly assigned to the GN60 group (60% concentrate of dry matter, GN60, n = 21) or GN70 group (70% concentrate of dry matter, n = 21) for a 3-months feeding trial. Results No difference was observed in the growth performance or plasma biochemical parameters between the GN60 group and the GN70 group. The hepatic TG concentration was higher in the GN70 group than GN60 group (P < 0.05). Hepatic transcriptomic analysis showed that there were 290 differentially expressed genes identified between GN60 and GN70 groups, with 125 genes up-regulated and 165 genes down-regulated in the GN70 group. The enriched Gene Ontology (GO) items and KEGG pathways and protein–protein interaction (PPI) network of differentially expressed genes (DEGs) revealed that the majority of enriched pathways were related to lipid metabolism. Further analysis revealed that the fatty acid synthesis was up-regulated, while fatty acid transport, oxidation, and TG degradation were down-regulated in the GN70 group when compared with the GN60 group. Conclusions These results indicated that GN70 induced excess lipid deposition in the liver of lambs during the fattening period, with high synthesis rates and low degradation rates of TG. The identified mechanisms may help understand hepatic metabolism in lambs with a high concentrate diet and provide insight into decreasing the risk of liver metabolism disorder in animals.

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Relationship between level of forage intake, blood flow and oxygen consumption by splanchnic tissues of sheep fed a tropical grass forage

Cited by 7 publications

References 22 publications

Oxygen uptake and net flux of metabolites by splanchnic tissues of sheep in response to short‐term mesenteric infusion of nitrogenous compounds

Oxygen uptake and net flux of metabolites by splanchnic tissues of sheep in response to short‐term mesenteric infusion of nitrogenous compounds

Spineless cactus associated with Tifton hay or sugarcane bagasse may replace corn silage in sheep diets

Genome wide transcriptome analysis provides bases on hepatic lipid metabolism disorder affected by increased dietary grain ratio in fattening lambs

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