Relationship between liver tumors and age in brown bullhead populations from two Lake Erie tributaries

Baumann, Paul C.; Harshbarger, John C.; Hartman, Kyle J.

doi:10.1016/0048-9697(90)90365-2

Cited by 96 publications

(99 citation statements)

References 10 publications

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“…Baumann et al (1987) demonstrated an increased frequency of liver tumours with age in brown bullheads Ictalurus nebulosus and also that 4 to 5 yr old fish had a significantly higher prevalence of biliary carcinomas than 2 to 3 yr old ones collected at the same site (Baumann et al 1990). Furthermore, the latter study demonstrated a relative lack (or even absence) of fish of age ≥ 5 yr at sites with the highest liver tumour prevalence, suggesting an age-selective mortality associated with the disease (Baumann et al 1990). Similar patterns had previously been observed in the marine flatfish Parophrys vetulus whereby fish of age < 4 yr were rarely observed with liver neoplasia , Myers et al 1998a).…”

Section: Introductionmentioning

confidence: 79%

“…Similar patterns had previously been observed in the marine flatfish Parophrys vetulus whereby fish of age < 4 yr were rarely observed with liver neoplasia , Myers et al 1998a). Baumann et al (1990) state that direct comparison of neoplasia frequency between sites or species is problematic since tumour data has not been related to sex or age data from the same fish, a feature also highlighted by Myers et al (1998a), Rhodes et al (1987) and Stehr et al (2004) in their studies on liver tumours in marine flatfish sampled from US waters. Related work on the flatfish dab Limanda limanda from European waters has demonstrated how the frequency of DNA lesions (strand breaks and the formation of adducts) increases with age; this likely is an outcome of cumulative biotransformation of pollutants over time in older fish (Akcha et al 2004).…”

Section: Introductionmentioning

confidence: 99%

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Effect of age on liver pathology and other diseases in flatfish: implications for assessment of marine ecological health status

Stentiford¹,

Bignell²,

Lyons³

et al. 2010

Mar. Ecol. Prog. Ser.

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Age at disease onset, a familiar concept in human medicine, has not been commonly discussed in relation to diseases of wildlife. Furthermore, while age has been anecdotally linked with disease susceptibility in aquatic animals (e.g. in aquaculture), little attention has been devoted to health of specific cohorts in wild aquatic animal populations. In an attempt to refine current approaches to marine environmental monitoring programmes that utilise fish diseases as a sentinel for ecological status, we have investigated age at onset for 10 disease variables in the flatfish Limanda limanda, a commonly utilised species in such programmes in Europe. By comparing the prevalence of these variables (including several associated with liver neoplasia) in different age classes from the same sites, we have demonstrated an increased propensity for 'harm' (a cumulative measure of multiple disease variables) with age. Furthermore, a comparison of age-matched cohorts from geographically distinct offshore marine sites revealed that this tendency for increased harm differs in magnitude between sites. In these scenarios, the age at onset for key disease variables (such as pre-neoplastic and neoplastic pathologies of the liver) also differs between sites, with some locations containing populations with apparently increased susceptibility in younger age classes. We conclude that while age is an important variable when assessing fish population health status, it does not explain all of the differences in disease prevalence observed in natural populations, and further, that age-matched cohorts from certain populations have a higher propensity for disease than fish of the same age from other sites. The basis for these differences in susceptibility is discussed in relation to the prevailing burden of anthropogenic contaminants and to other natural factors (such as population genetics and migration) inherent in sampled populations.

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Section: Introductionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Effect of age on liver pathology and other diseases in flatfish: implications for assessment of marine ecological health status

Stentiford¹,

Bignell²,

Lyons³

et al. 2010

Mar. Ecol. Prog. Ser.

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Section: Discussionmentioning

confidence: 99%

“…There was no statistically significant correlation between age and tumour development, but the data indicate that skin tumours may be the primary tumours and develop earlier than visceral metastases; and also that the neoplasm may cause mortality, in that no 6 or 7 yr old rudd was found with a neoplasm. Baumann et al (1990) considered the scarcity of brown bullheads, over 4 yr of age in the Black River, Ohio to be due to the prevalence of hepatic carcinoma.The sex ratio results suggest a selective adverse effect on male survival, in which male hormones may play a part. While Nunez et al (1989) discussed the higher rates of certain neoplasms in female fish due to the promoter oestradiol, Kimura et al (1984) found the prevalence of chromatophoromas in croakers Nibea mitsukurii in coastal waters in Japan to be higher in males than in females.…”

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confidence: 99%

Epidemiology of squamous cell carcinomas in rudd Scardinius erythrophthalmus from SE Ireland

Hanajavanit¹,

Bermingham²,

Mulcahy³

2008

Dis. Aquat. Org.

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An epidemiological study was carried out to investigate the possible aetiology of squamous cell carcinomas which occur in a population of rudd Scardinius erythrophthalmus (L.) from Lough Aderry in south-east Ireland. A total of 1343 rudd were sampled from Lough Aderry and 2 nearby small lakes in spring, summer, autumn, and winter over 2 yr, 1986 to 1988. Fish were weighed, measured, sexed, aged, and examined for lesions. Water quality parameters and natural radioactivity were assessed as possible influencing factors in the disease. The prevalence of squamous cell carcinoma was 6.1% overall, with no significant difference between the lakes, seasons or years. Both male and female fish were affected, of ages from 1+ to 5+ yr. No fish of 6+ or 7+ yr was found with tumours, indicating that the neoplasm caused premature death. The female:male sex ratio of rudd with tumours was higher than that of healthy rudd overall, suggesting that males are more susceptible to the neoplasm. Of the parasites observed, Posthodiplostomum cuticola was common, but rarely found in rudd with tumours. Sphaerospora sp.was also common, but not in sufficient densities for statistical inference, and Argulus sp. was present on 7 fish. No viral particles were found. Natural radiation levels in the vicinity of the lakes were low. The lakes sampled are in an agricultural catchment, and the waters were eutrophic. While rudd are tolerant, it is likely that environmental conditions were stressful at least some of the time, with possible consequences for the immunocompetence of the rudd. The aetiology of the carcinoma is still unknown, but the possibilities of carcinogenic compounds resulting from the high nutrient levels, or of carcinogenic algal toxins produced during algal blooms, should be examined.KEY WORDS: Squamous cell carcinoma · Rudd · Length · Age · Sex · Environmental parameters Resale or republication not permitted without written consent of the publisherDis Aquat Org 80: [145][146][147][148][149][150][151][152][153][154][155][156] 2008 be environmental rather than viral in aetiology. Chemical contaminants in the water have been suggested as associated with the elevated tumour incidence (Black et al. 1982, Malins et al. 1984. Brown et al. (1973) stated that the presence of water pollution may enhance carcinogenesis in fish.The epidemiology of the neoplasm in rudd in Lough Aderry and in 2 nearby lakes was investigated over a period of 25 mo. This paper (1) reports on the prevalence of the tumours in rudd from the 3 lakes, (2) examines the relationship between the prevalence of the neoplasm and the size, age and sex of the fish and the season, and (3) examines the possible roles of water quality, natural radiation and parasitic infection in the disease. Natural radiation was examined because of regional concerns about radiation levels following the Chernobyl disaster. MATERIALS AND METHODS Fish samples. Preliminary samples of rudd were taken from Lough Aderry (Irish Grid Reference [IGR]W9473) and from Ballyhonock Lake (IGR W997...

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“…Studies of English sole (Paropyrys vetulus) in the Duwamish River unveiled a tumor incidence that appeared to correlate with polychlorinated biphenyl (PCB) levels (13,14 A study of tumor incidence among fish in the Black River in Ohio, which empties into Lake Erie, showed that in 1980, 1.2% of the 2-year-old and 33% of the 3-yearold brown bullheads collected from the river had liver tumors compared to a 0% incidence among fish in Buckeye Lake, the control site (20) Baumann (26) showed that the highest prevalence of liver tumors in brown bullheads from Lake Erie was in 4-to 5-year-old fish, but that 6-to 7-year-old fish were completely absent from the lake and their age group represented 18% of the total catch from uncontaminated sites. Thus, neoplasia-induced mortality may result in underestimates of tumor incidence among fish populations.…”

Section: Introductionmentioning

confidence: 99%

Chronic Toxicity of Environmental Contaminants: Sentinels and Biomarkers

LeBlanc¹,

Bain²

1997

Environmental Health Perspectives

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Due to the use of a limited number of species and subchronic exposures, current ecological hazard assessment processes can underestimate the chronic toxicity of environmental contaminants resulting in adverse responses of sentinel species. Several incidences where sentinel species have responded to the effects of chronic exposure to ambient levels of environmental contaminants are discussed, including the development of neoplasia in fish, immunosuppression in marine mammals, pseudohermaphrodism in invertebrates, teratogenicity in amphibians, and aberrations in the sexual development of fish and reptiles. Biomarkers of chronic toxicity, including DNA mutations, alterations in specific protein and mRNA levels, and perturbations in metabolism, are presented. The incorporation of appropriate surrogate species and biomarkers of chronic toxicity into standard toxicity characterizations is proposed as a means of significantly refining the ecological hazard assessment process. -Environ Health Perspect 105(Suppl 1): 65-80 (1997)

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Relationship between liver tumors and age in brown bullhead populations from two Lake Erie tributaries

Cited by 96 publications

References 10 publications

Effect of age on liver pathology and other diseases in flatfish: implications for assessment of marine ecological health status

Effect of age on liver pathology and other diseases in flatfish: implications for assessment of marine ecological health status

Epidemiology of squamous cell carcinomas in rudd Scardinius erythrophthalmus from SE Ireland

Chronic Toxicity of Environmental Contaminants: Sentinels and Biomarkers

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