Relationship between long non-coding RNA and prognosis of patients with coronary heart disease after percutaneous coronary intervention

Wang, Fei; Cai, Xiaoqing; Jiao, Piqi; Liu, Yan; Yuan, Bin; Zhang, Peng; Liu, Hongbin; Ma, Liang

doi:10.1097/md.0000000000023525

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…The score of fear of movement was (39.52 ± 8.63), which was at a high level, and the incidence rate of fear of movement was 52.9%. Wang Zi an et al [23] conducted a longitudinal study on patients with acute myocardial infarction after PCI. The results showed that the level of fear of movement began to increase slowly 1 week after surgery, peaked at 2 weeks after discharge, and began to gradually decrease after 2 weeks, but after 3 weeks after discharge, it has not dropped to normal levels and below for several months.…”

Section: Current Status Of Fear Of Movement In Patients With Coronary...mentioning

confidence: 99%

Fear of Movement in Patients with Coronary Heart Disease: A Comprehensive Review

2023

FMSR

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Cardiovascular disease (CVD)is a leading cause of death worldwide. Coronary heart disease (CHD), the most common type of CVD, is a major cause of morbidity and mortality. With the advancement of modern medicine, the survival rate and early prognosis of patients with CHD have been greatly improved, but long-term prognosis and quality of life still depend on secondary prevention.Exercise-based cardiac rehabilitation is a crucial intervention for the secondary prevention in patients with CHD, with benefits including improved physical condition, recovery from illness, improved drug treatment efficacy, enhanced immunity, lipid regulation, and improved myocardial blood supply and cardiac function. However, the prevalence of fear of movement in patients with CHD is high, which is an important factor affecting patient adherence to exercise and rehabilitation outcomes.This review summarizes the prevalence, influencing factors, and intervention measures in patients with CHD, to provide a reference for improving patient adherence to exercise and rehabilitation outcomes.

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Section: Current Status Of Fear Of Movement In Patients With Coronary...mentioning

confidence: 99%

Fear of Movement in Patients with Coronary Heart Disease: A Comprehensive Review

2023

FMSR

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“…However, due to the diferent degree of coronary artery stenosis, the imaging evaluation is highly subjective, and the infuence of the degree of stenosis on the distal blood fow cannot be obtained [8,9]. In recent years, researchers have used computed tomography (CT) to reconstruct the model of coronary artery in three dimensions and computer blood fow simulation to obtain noninvasive fractional fow reserve (FFR), which has gradually deepened the application of FFR [10]. FFR is defned as the ratio of maximum blood fow at both ends of coronary artery stenosis measured in the case of vascular expansion.…”

Section: Introductionmentioning

confidence: 99%

Functional Evaluation of Percutaneous Coronary Intervention Based on CT Images of Three-Dimensional Reconstructed Coronary Artery Model

Liu

Shao

et al. 2023

Contrast Media & Molecular Imaging

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In order to explore the computerized tomography (CT) based on three-dimensional reconstruction of coronary artery model, the functional evaluation was made after percutaneous coronary intervention (PCI). In this study, 90 patients with coronary heart disease who received elective PCI were selected. The blood flow reserve fraction (FFR) and SYNTAX score were calculated by three-dimensional reconstruction of CT images, followed up for 2–4 years. According to the SYNTAX score, 0–22 points were defined as the low group (28 cases), 23–32 points as the medium group (33 cases), and 33 points as the high group (29 cases). In this paper, the accuracy, sensitivity, and specificity of CT images of three-dimensional reconstructed coronary artery model are 91%, 73%, and 62%, respectively. The follow-up results showed that the incidence of major adverse cerebrovascular events in the high group was significantly higher than that in the low group and the middle group, and the difference was statistically significant ( P < 0.05 ). Pearson correlation analysis showed that SYNTAX score was related to serum total cholesterol (r = 0.234, P = 0.003 ), triglyceride (r = 0.237, P = 0.014 ), low-density lipoprotein cholesterol (r = 0.285, P = 0.004 ), and ApoB/ApoA1 (R = 0.004). In this study, FFR is calculated by CT images based on three-dimensional reconstruction of coronary artery model, which can provide support for the diagnosis and treatment of coronary heart disease. SYNTAX score can be used as a risk predictor for PCI patients with coronary heart disease.

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“…Long noncoding RNAs (lncRNAs) defined as nonprotein-coding RNAs longer than 200 nucleotides [13]. Some studies verified that the abnormal expression of lncRNA in CHD [14][15][16]. Liu et al reported that lncRNA-ANRIL is expressed low in the serum of patients with CHD, and it has high predictive value both for effective treatment and for poor prognosis of them.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Landscape of Modules-Dysregulated Functions Reveals a Profound Role of ceRNAs in Coronary Heart Disease

Chen

Wang

Feng

et al. 2022

Journal of Healthcare Engineering

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Coronary heart disease (CHD) is one of the most common severe cardiovascular diseases. Competitive endogenous RNAs (ceRNA) play critical roles in complex diseases. However, our understanding of the dysregulated functions of ceRNAs in CHD remains limited. Here, we systematically analyzed the alterations of ceRNAs and identified the specific functions based on dysregulated modules from the ceRNA network. A total of 2457 significantly differential expressed genes and 212 differential expressed lncRNAs were identified. We got 76679 regulator relationship between different expression genes and miRNAs and 336 regulator relationship between differential expressed lncRNAs and miRNAs. We constructed the ceRNA network and selected five dysregulated modules. Furthermore, CHD specific functions based on dysregulated modules from the ceRNA network were identified, including histone acetylation, platelet degranulation, cAMP-dependent protein kinase complex, xenobiotic transport and so on. Our results will provide novel insight for a better understanding of the mechanism of ceRNAs and facilitate the identification of novel diagnostic and therapeutic biomarkers in CHD.

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Relationship between long non-coding RNA and prognosis of patients with coronary heart disease after percutaneous coronary intervention

Cited by 4 publications

References 23 publications

Fear of Movement in Patients with Coronary Heart Disease: A Comprehensive Review

Fear of Movement in Patients with Coronary Heart Disease: A Comprehensive Review

Functional Evaluation of Percutaneous Coronary Intervention Based on CT Images of Three-Dimensional Reconstructed Coronary Artery Model

Comprehensive Landscape of Modules-Dysregulated Functions Reveals a Profound Role of ceRNAs in Coronary Heart Disease

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