Relationship between low serum endogenous androgen concentrations and arterial stiffness in men with type 2 diabetes mellitus

Low testosterone in men predicts impaired arterial elasticity and microvascular function

“…For example, six months of androgen-deprivation therapy for prostate cancer showed increased arterial stiffness [45]. In diabetics, free testosterone and dehydroepiandrosterone sulfate (DHEA-S) levels were inversely associated with PWV, a measure of central arterial stiffness [46]. Additionally, testosterone level was independently predictive of PWV in an older population with greater co-morbidities [47].…”

Gonadal and adrenal androgen deficiencies as independent predictors of increased cardiovascular mortality in men with type II diabetes mellitus and stable coronary artery disease

“…Previous studies have reported that men with type II DM are prone to develop androgen deficiency [7,8]. In these patients, decreased levels of circulating testosterone and DHEAS are related to poor metabolic control, insulin resistance and other cardiovascular risk factors, are associated with an increased arterial stiffness and the severity of carotid atherosclerosis [9,10]. It can indirectly explain the association between androgen deficiencies and high risk of CV complications among patients with type II DM and CAD.…”

“…Decreased levels of circulating testosterone and dehydroepiandrosterone are frequent in men with type II DM [7,8], are related to metabolic disease severity, and coincide with the other risk factors and the severity of carotid atherosclerosis, all of which predict a high risk of CV complications [9,10]. So far, the impact of androgen deficiencies on prognosis in men with type II DM and CAD has not been evaluated.…”

Evaluation of Androgen Levels in Patients with Acute Coronary Syndrome

“…DHEA-S and testosterone might play a protective role on the endothelial function of males [5,6]. Testosterone decreased within first 24 hours after myocardial infarction [7].…”