Relationship between Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia and Metabolic Syndrome in Korean Men

Abstract

PurposeTo investigate any associations between lower urinary tract symptoms (LUTS)/benign prostate hyperplasia (BPH) and metabolic syndrome (MetS).Materials and MethodsIn all, 1,224 male police officers in their 50s who had participated in health examinations were included. LUTS/BPH was assessed by serum prostate-specific antigen, International Prostate Symptom Score (IPSS), transrectal ultrasonography, maximum urinary flow rate (Q max), and postvoid residual urine volume (PVR). In addition, testosterone was also examined. The MetS was defined using NCEP-ATP III guidelines. We used the multiple linear regression test and logistic regression analyses to examine the relationships.ResultsMetS was diagnosed in 29.0% of participants. There was no significant difference in the percentage of cases of BPH (IPSS >7, Q max <15 ml/sec, and prostate gland volume ≥ 20 ml) (14.2% in the non-MetS group vs. 17.2 in the MetS group; p value=0.178). The total IPSS score and the Q max were not significantly different. The prostate volume and PVR were significantly greater in the subjects with MetS. After adjusting for age and testosterone, the presence of MetS was not associated with BPH (multivariate odds ratio, 1.122; 95% confidence interval, 0.593~2.120). Additionally, MetS was not related to IPSS (Beta, -0.189; p value=0.819), prostate volume (Beta, 0.815; p value=0.285), Q max (Beta, -0.827; p value=0.393), or PVR (Beta, 0.506; p value=0.837).ConclusionsAccording to our results, the MetS was not clearly correlated with LUTS/BPH in Korean men in their 50s.

Meta-analysis of metabolic syndrome and benign prostatic hyperplasia in Chinese patients

“…Another study in China [20] indicated that prostate volume was not related to MeS in BPH patients under 50 years of age . In a study of Korean men in their 50 years, no significant differences were found in mean total prostate volume between MetS and without MetS [38]. These inconsistent findings might be explained by the different age distribution.…”

Benign prostatic enlargement can be influenced by metabolic profile: results of a multicenter prospective study

“…In their study, annual transitional prostate volume (TPV) growth rate was significantly higher in BPH patients with MetS as compared with those without MetS (1.019 ml/yr vs 0.699 ml/yr, respectively). After this preliminary work, several authors have documented a possible association between MetS and BPH [14–16] but other authors didn’t confirm this association [17]. Interestingly in a meta-analysis of the available evidence we found that subjects with MetS had significantly higher total prostate volume when compared to those without MetS (+1.8 [95% CI: 0.74;2.87] ml; p  < 0.001) and these datas are in agreement to the present one.…”

Are Middle‐Aged Men with Chronic Kidney Disease at Higher Risk of Having Nocturia than Age‐Matched Controls

“…Several studies reported a positive correlation between MetS and nocturia . However, recent studies on middle‐aged men from health check‐ups did not find that MetS was associated with nocturia …”