Relationship between lung function values and air pollution data, in Budapest schoolchildren

Mándi, A; Galambos, E; Galgóczy, G.; Szabo, M.F.; Kollár, Katalin

doi:10.1007/bf02179323

Cited by 4 publications

(2 citation statements)

References 41 publications

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“…Current knowledge on the effects of air pollution exposure on total lung capacity and diffusing capacity is limited and mixed. Some animal [ 17 – 20 ] and human [ 21 – 34 ] studies have shown that exposure to air pollution has adverse effects on total lung capacity [ 17 , 23 , 24 , 26 – 28 ] and diffusing capacity [ 19 , 20 , 23 , 24 , 29 – 33 ], but others have shown no effects [ 18 , 21 , 22 , 25 , 34 ]. Most previous studies have focused on acute [ 20 , 25 , 28 – 30 , 32 – 34 ] or short-term [ 21 – 24 ] effects, but only a few have reported long-term effects [ 17 – 19 , 26 , 27 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

“…Some animal [ 17 – 20 ] and human [ 21 – 34 ] studies have shown that exposure to air pollution has adverse effects on total lung capacity [ 17 , 23 , 24 , 26 – 28 ] and diffusing capacity [ 19 , 20 , 23 , 24 , 29 – 33 ], but others have shown no effects [ 18 , 21 , 22 , 25 , 34 ]. Most previous studies have focused on acute [ 20 , 25 , 28 – 30 , 32 – 34 ] or short-term [ 21 – 24 ] effects, but only a few have reported long-term effects [ 17 – 19 , 26 , 27 , 31 ]. No studies have reported the long-term effect of air pollution exposure on the decline total lung capacity and diffusion capacity.…”

Section: Introductionmentioning

confidence: 99%

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Air pollution enhance the progression of restrictive lung function impairment and diffusion capacity reduction: an elderly cohort study

Chen

Lee

et al. 2022

Respir Res

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Background Some evidences have shown the association between air pollution exposure and the development of interstitial lung diseases. However, the effect of air pollution on the progression of restrictive ventilatory impairment and diffusion capacity reduction is unknown. This study aimed to evaluate the effects of long-term exposure to ambient air pollution on the change rates of total lung capacity, residual volume, and diffusion capacity among the elderly. Methods From 2016 to 2018, single-breath helium dilution with the diffusion capacity of carbon monoxide was performed once per year on 543 elderly individuals. Monthly concentrations of ambient fine particulate matters (PM2.5) and nitric dioxide (NO2) at the individual residential address were estimated using a hybrid Kriging/Land-use regression model. Linear mixed models were used to evaluate the association between long-term (12 months) exposure to air pollution and lung function with adjustment for potential covariates, including basic characteristics, indoor air pollution (second-hand smoke, cooking fume, and incense burning), physician diagnosed diseases (asthma and chronic airway diseases), dusty job history, and short-term (lag one month) air pollution exposure. Results An interquartile range (5.37 ppb) increase in long-term exposure to NO2 was associated with an additional rate of decline in total lung volume (− 1.8% per year, 95% CI: − 2.8 to − 0.9%), residual volume (− 3.3% per year, 95% CI: − 5.0 to − 1.6%), ratio of residual volume to total lung volume (− 1.6% per year, 95% CI: − 2.6 to − 0.5%), and diffusion capacity (− 1.1% per year, 95% CI: − 2.0 to − 0.2%). There is no effect on the transfer factor (ratio of diffusion capacity to alveolar volume). The effect of NO2 remained robust after adjustment for PM2.5 exposure. Conclusions Long-term exposure to ambient NO2 is associated with an accelerated decline in static lung volume and diffusion capacity in the elderly. NO2 related air pollution may be a risk factor for restrictive lung disorders.

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