Relationship between Macula Pigment Optical Density and Visual Performances in Patients with dry Age related Macular Degeneration accompanied with Macula Drusens

Abstract

Objectives: To determine the relationship between Macula Pigment Optical Density and Visual Performances (foveal sensitivity, Contrast sensitivity and stereo acuity) in patients with Dry Age Related Macular Degeneration accompanied with Macular Drusen. To evaluate the awareness of patients about the condition Methods: A descriptive cross sectional study according to convenience sampling was carried out with 80 patients (160 eyes) aged 44-65 for duration of 14 months. Data was recorded in each subject by carrying out a questionnaire including Demographic profile, Visual Functions; (Foveal sensitivity-measured by Humphrey Field Analyzer), Contrast sensitivity (by lea contrast acuity chart), stereo acuity (by TNO test). Thickness of macula & presence of drusen-measured by Cirrus 5000 spectral domain Optical Coherence Tomography and Macula pigment optical density by Zeiss Visucam 500 MPOD mode ,AMD was graded into 3stages by the presence of 15 or more macular drusen > 63μm and all were again divided in to 3 subgroups according to MPOD levels[2]. All data were analyzed using SPSS software. Results: Mean MPOD levels in 160 subjects, Stage-1-0.41, Stage-2-0.31, Stage-3-0.17 Mean Foveal sensitivity (MFS); low range=15 dB, mid-range=21, high-range=26dB, Mean Contrast sensitivity; low-range=25%, mid-range=5%, high-range=2.5% and Mean Stereo acuity; low range=480 sec of arc, mid-range=240 sec of arc high-range=60 sec of arc.

The relationship between inflammatory biomarkers and macular pigment optical density in hypertensive patients: a cross-sectional study

“…A macular pigment composes of 2 carotenoids, lutein and zeaxanthin, with absorption spectra in the 400–540 nm spectral range and maximal absorption of 460 nm. Because of its ability to absorb blue light and scavenge free radicals, the macular pigment may help prevent AMD [ 2 ]. MPOD reflects the amount of lutein and zeaxanthin in the macular pigment region related to the ability of the macular pigment to absorb blue light.…”