Relationship between Mammography Breast Density and Bone Mineral Density

Gupta, Renu; Alhajri, Fayzah A; Mohammed, Ahmed; Chavan, V.N.K.; Gupta, P.

doi:10.1016/j.jocd.2007.11.001

Cited by 6 publications

(5 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, studies evaluating the association of BMD with percent mammographic density have not stratified their analyses by BMI, except for one conducted among Kuwaiti women. 32 It should be noted that one study not included in this review, because it reported breast density using the BI-RADS classification rather than percent mammographic density, reported a small, but significant negative association between BMD at hip and breast density among postmenopausal women with normal weight and no relationship in overweight or obese women. 46 Scattered fibroglandular densities and heterogeneously dense categories have wide percent mammographic density ranges and have large overlaps of percentage density in qualitative BI-RADS categories 2-4, and this may introduce limitations to their study.…”

Section: Bmi Bmd and Mammographic Densitymentioning

confidence: 94%

“…Six studies have investigated the association of BMD at the hip with percent mammographic density 27,[29][30][31][32][33] ( Table 2). The studies that investigated associations among all women regardless of menopausal status reported no association.…”

Section: Bmd At the Hipmentioning

confidence: 99%

“…Furthermore, if mammographic density is associated with BMD, knowing a woman's breast density might have some utility in predicting BMD, and possibly future fracture risk since BMD is a strong predictor of future fracture risk. 26 The few studies that have investigated the association of BMD with percent mammographic density, [27][28][29][30][31][32][33][34] have produced conflicting results, and no review of the topic has been undertaken. To extend knowledge on the association of BMD with percent mammographic density, we conducted a systematic review of published studies.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Is There an Association Between Bone Mineral Density and Mammographic Density? A Systematic Review

Lee

Holley

Appleton

et al. 2017

Journal of Women's Health

View full text Add to dashboard Cite

show abstract

Section: Bmi Bmd and Mammographic Densitymentioning

confidence: 94%

Section: Bmd At the Hipmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Is There an Association Between Bone Mineral Density and Mammographic Density? A Systematic Review

Lee

Holley

Appleton

et al. 2017

Journal of Women's Health

View full text Add to dashboard Cite

show abstract

“…Several prior studies considered current versus past or ever use of HT 9 while others were able to stratify more finely (e.g., recent past use vs. never use) 14, 20–22, 24 . Some authors did not mention adjustment for HT use 23, 25 . Given residual effects of HT use on breast density, the various considerations of HT use across previous analyses may contribute to divergent results.…”

Section: Discussionmentioning

confidence: 99%

Bone mineral density and mammographic density in Mexican women

Moseson

Rice

López‐Ridaura³

et al. 2015

Cancer Causes Control

View full text Add to dashboard Cite

Background Bone mineral density (BMD) is a putative marker for lifetime exposure to estrogen. Studies that have explored whether BMD is a determinant of mammographic density (MD) have observed inconsistent results. Therefore, we examined this potential association in a sample of women (N=1,516) from the clinical sub-cohort in the Mexican Teachers’ Cohort (N=115,315). Methods We used multivariable linear regression to assess the association between quartiles of BMD and percent MD, as well as total dense and non-dense area of the breast, stratified by menopausal status. We also examined the associations by body mass index (BMI) (<30kg/m2,, ≥30kg/m2). Results Overall, there was no association between BMD and MD among premenopausal women. However, when we stratified by BMI, there was a modest inverse association between BMD and percent MD (difference between extreme quartiles= −2.8, 95%CI: −5.9, 0.27, p-trend=0.04) among women with BMI <30 kg/m2, but a positive association among obese women (comparable difference=5.1, 95%CI: 0.02, 10.1, p-trend=0.03; p-interaction<0.01). Among postmenopausal women, BMD and percent MD were positively associated after adjustment for BMI (p-trend<0.01). Postmenopausal women in the highest two quartiles of BMD had 4–5 percentage point higher percent MD compared to women in the lowest quartile. The association did not differ by BMI in postmenopausal women (p-interaction=0.76). Conclusion Among obese premenopausal women as well as postmenopausal women, BMD was positively associated with percent MD. Among leaner premenopausal women, BMD and percent MD were modestly inversely associated. These findings support the hypothesis that cumulative exposure to estrogen (as measured by BMD) may influence MD.

show abstract

“…However, recent evidences suggested that the relationship between MBD and BMD are still unclear (Kerlikowske et al 2005;Gupta et al 2008;Sung et al 2011). According to previous research, dietary factor were thought to be responsible for about 30% of all cancers in developed countries and for 20% in developing countries (Key et al 2004;Linos et al 2007;Nahleh et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Association of Bone Mineral Density to Dietary Intake and Predictors of Breast Cancer in Premenopausal and Postmenopausal Malaysian Women

Zain

Chelliah

Seriramulu

et al. 2017

JSKM

View full text Add to dashboard Cite

Daily food intake of women may affect their bone health by altering their bone mineral density (BMD) as the lack of certain nutrients may affect bone integrity whilst, BMD also can be a predictor of breast cancer. To date, many studies have been conducted to discuss on association of BMD and mammographic breast density (MBD) and how both are related to breast cancer risks but no consideration has been made on dietary intake. Therefore, this study was designed to determine the association of dietary intake with BMD and other breast cancer risk factors. A cross-sectional study on 76 pre-and postmenopausal women above 40 years underwent mammogram screening and Dual Energy X-ray Absorptiometry (DEXA) was conducted in Hospital Kuala Lumpur (HKL) for the duration of 1 year. Purposive sampling method was used to choose the respondents. Women who are diagnosed with breast cancer and underwent cancer treatment were excluded from this study. DEXA unit (Hologic Discovery W, Hologic, Inc) were used to measure BMD at the femoral neck and lumbar spine in grams per centimetre squared (g/cm 2) and they were classified into normal and abnormal group based on the T-scores. The subjects were asked about their daily dietary pattern for a duration of three days using Diet History Questionnaire (DHQ). The mean of selected characteristics were compared between groups. Additionally, binary logistic regression was used to determine the association between diet intake with BMD and other risk factors of breast cancer. The total number of pre-and postmenopausal women who consented to participate in this study are equal. The mean age was 47.1 years and 54.9 years for premenopausal and postmenopausal women respectively. The results indicate only menopausal age of the women was statistically significant (p < 0.05). A number of 17% premenopausal and 9% of postmenopausal women showed to have family history of breast cancer, however, it was not statistically significant (p = 0.12). There was no significant difference in daily energy intake of food in both groups (p = 0.22). None of the nutrients in daily food intake showed to be statistically significant. Menstrual status showed an association with BMD with p < 0.05 and the remaining risk factors did not show any association. Logistic regression revealed that only menstrual status had correlation with BMD in both groups. This study provided the dietary pattern and the effects on bone health. The association of other risk factors of breast cancer with BMD were also analysed and most of it showed a negative association.

show abstract

Relationship between Mammography Breast Density and Bone Mineral Density

Cited by 6 publications

References 21 publications

Is There an Association Between Bone Mineral Density and Mammographic Density? A Systematic Review

Is There an Association Between Bone Mineral Density and Mammographic Density? A Systematic Review

Bone mineral density and mammographic density in Mexican women

Association of Bone Mineral Density to Dietary Intake and Predictors of Breast Cancer in Premenopausal and Postmenopausal Malaysian Women

Contact Info

Product

Resources

About