Relationship between MCP1 (-2518A>G) gene variants and ovarian cancer in Turkish population

Abstract

The monocyte chemoattractant protein-1 (MCP-1) gene polymorphism(-2518A>G) in the regulatory region of the MCP-1 protein has been reported to be associated with cancer risk. In this study we aimed to investigate the relationship of MCP-1 (-2518A>G) gene polymorphism and ovarian cancer. MCP-1 genotyping was performed using polymerase chain reaction from blood samples ofovarian cancer patient (n=56) and a control groups (n=52).There was a significant difference in MCP1 (-2518A>G) genotypes between the patient and control groups (p=0.049; x2=6.042). AA carriers were significantly higher in the control group (p=0.014) whereas AG genotype and G allele carriers were significantly higher in the ovarian cancer group (p=0.029, p=0.014, respectively). This study suggests that MCP-1 (-2518A>G) AG genotype and G allele could be considered as risk factor for susceptibility to ovarian cancer.

The association between single nucleotide polymorphisms and ovarian cancer risk: A systematic review and network meta‐analysis

“…Bsm1 (G>A) rs1544410 49,55,56 CDKN1B rs2066827 8,57,58 CDKN2A rs3731249 8,59 Cdx-2 rs11568820 47,54 COMT rs4680 [60][61][62][63][64][65][66] COX-2/PTGS2 rs20417, 67 rs5275 LncRNA-HOTAIR rs4759314 110,111 MCP-1 rs1024611 [112][113][114][115] MDM2 rs2279744, [116][117][118] rs117039649 116,119 MGAT5 rs1257187 95 miR-146a rs2910164 41,120,121 miR-196a2 rs11614913 19,41,120,121,122 MLH1 rs1800734 [123][124][125][126] remarkable correlation with increased OC risk compared to the CC and CT genotypes (TT vs. CC + CT: pooled OR = 3.211, 95% CI: 1.707-6.037). According to the fixed effects model, the AA genotype of ERCC1 rs3212986 was associated with increased OC risk compared to the CA and CC genotypes (AA vs. CA + CC: pooled OR = 1.636, 95% CI: 1.220-2.194).…”