Relationship between mean habitual daily energy expenditure and maximal oxygen uptake

Berthouze, Sophie E.; Minaire, P; Castells, J.; Busso, Thierry; Vico, Laurence; Lacour, Jean‐René

doi:10.1249/00005768-199508000-00011

Cited by 68 publications

(34 citation statements)

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“…We identified VO 2 max as a strong determinant of both the paretic proximal femur BMD and paretic leg lean mass in older individuals with chronic stroke. Reduction in VO 2 max is related to decreased habitual physical activity in healthy populations [36]. Our finding thus highlights the importance of physical activity and fitness on muscle and bone health in individuals with stroke.…”

Section: Influence Of Stroke-specific Impairmentssupporting

confidence: 58%

“…In this study, we used a standardized and objective measure, namely maximal oxygen uptake (VO 2 max), as an indictor of physical work capacity. VO 2 max is accepted as the standard measure of cardiorespiratory fitness (ACSM, 2000) and is associated with level of habitual physical activity [35,36]. As low VO 2 max is commonly observed in people with stroke, it may be an important factor in bone health in this group [37].…”

Section: Physical Fitnessmentioning

confidence: 99%

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Reduced hip bone mineral density is related to physical fitness and leg lean mass in ambulatory individuals with chronic stroke

et al. 2005

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Following a stroke, reduced level of physical activity and functional use of the paretic leg may lead to bone loss and muscle atrophy. These factors and the high incidence of falls may contribute to hip fractures in the stroke population. This study was the first to examine total proximal femur bone mineral content (BMC) and bone mineral density (BMD) and their relationship to strokespecific impairments in ambulatory individuals with chronic stroke (onset >1 year). We utilized dual-energy X-ray absorptiometry (DXA) to acquire proximal femur and total body scans on 58 (23 women) community-dwelling individuals with chronic stroke. We report total proximal femur BMC (g) and BMD (g/cm 2 ) derived from the proximal femur scans, and lean mass (g) and fat mass (g) for each leg derived from the total body scans. Each subject was evaluated for ambulatory capacity (Six Minute Walk Test), knee extension strength (hand-held dynamometry), physical fitness [Maximal oxygen uptake (VO 2 max)], and spasticity (Modified Ashworth Scale). Results showed that the paretic leg had significantly lower proximal femur BMD, lean mass, and percent lean mass but higher fat mass than the non-paretic leg for both men and women. Proximal femur BMD of the paretic leg was significantly related to ambulatory capacity (r=0.33, p=0.011), muscle strength (r=0.39, p=0.002), physical fitness (r=0.57, p<0.001) but not related to spasticity (r= −0.23, p=0.080). Multiple regression analysis showed that lean mass in the paretic leg was a major predictor (R 2 =0.371, p<0.001) of the paretic proximal femur BMD. VO 2 max was a significant predictor of both paretic proximal femur BMD (R 2 =0.325, p<0.001) and lean mass in the paretic leg (R 2 =0.700, p<0.001). Further study is required to determine whether increasing physical fitness and lean mass is important to improve hip bone health in chronic stroke.

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Section: Influence Of Stroke-specific Impairmentssupporting

confidence: 58%

Section: Physical Fitnessmentioning

confidence: 99%

Reduced hip bone mineral density is related to physical fitness and leg lean mass in ambulatory individuals with chronic stroke

et al. 2005

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“…The potential clinical relevance of the small but significant improvement in exercise capacity in the rosiglitazonetreated group is supported by the potent negative impact that physical inactivity has on diabetes control and weight management and the possible benefits a drug that improved exercise capacity might therefore confer (11,32). Because V O 2max is positively correlated with habitual physical activity (33,34), this relationship is of practical significance as well.…”

Section: Endothelial Function and Blood Flowmentioning

confidence: 96%

Rosiglitazone Improves Exercise Capacity in Individuals With Type 2 Diabetes

2005

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OBJECTIVE -Although exercise is recommended as a cornerstone of treatment for type 2 diabetes, it is often poorly adopted by patients. We have noted that even in the absence of apparent cardiovascular disease, persons with type 2 diabetes have an impaired ability to carry out maximal exercise, and the impairment is correlated with insulin resistance and endothelial dysfunction. We hypothesized that administration of a thiazolidinedione (TZD) agent would improve exercise capacity in type 2 diabetes.RESEARCH DESIGN AND METHODS -Twenty participants with uncomplicated type 2 diabetes were randomly assigned in a double-blind study to receive either 4 mg/day of rosiglitazone or matching placebo after baseline measurements to assess endothelial function (brachial artery diameter by brachial ultrasound), maximal oxygen consumption (V O 2max ), oxygen uptake (V O 2 ) kinetics, and insulin sensitivity by hyperinsulinemic-euglycemic clamp. Measurements were reassessed after 4 months of treatment.RESULTS -Participant groups did not differ at baseline in any measure. Rosiglitazonetreated participants (n ϭ 10) had significantly improvedbefore rosiglitazone vs. 21.2 Ϯ 5.1 ml ⅐ kg Ϫ1 ⅐ min Ϫ1 after rosiglitazone, P Ͻ 0.01), insulin sensitivity, and endothelial function. A change in V O 2max correlated with improved insulin sensitivity measured by clamp (r ϭ 0.68, P Ͻ 0.05) and with improved brachial artery diameter (r ϭ 0.70, P Ͻ 0.05). Placebo-treated participants (n ϭ 10) showed no changes inCONCLUSIONS -This is the first known report showing that a TZD improved exercise function in type 2 diabetes. Whether this is due to the observed improvements in insulin sensitivity and/or endothelial function or to another action of the TZD class requires further exploration. Diabetes Care 28:2877-2883, 2005E ven in the absence of cardiovascular disease, persons with type 2 diabetes have an impaired ability to carry out maximal exercise in that maximal oxygen consumption (V O 2max ) is reduced by ϳ20% compared with that in control subjects similar in terms of age and physical activity level (1-3). In addition, oxygen consumption (V O 2 ) at submaximal workloads is reduced during graded exercise in type 2 diabetes compared with that in healthy control subjects as has previously been observed in disease states with impaired oxygen delivery (1,4). Also, V O 2 kinetics are slowed during constant load exercise in type 2 diabetes (5). Thus, there are many exercise abnormalities associated with type 2 diabetes.The relationship between exercise capacity and insulin resistance is of interest because the association between higher levels of physical activity/exercise training status and improved insulin sensitivity is well established (6 -8). Conversely, decreased habitual physical activity is known to be associated with poorer diabetic status (9). Population studies reveal a direct correlation between all-cause mortality and reduced fitness in persons with and without type 2 diabetes (10,11). Previous work from our group and others demonstrates a...

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“…Physical Activity Assessment . Physical activity is evaluated using the Physical Activity Questionnaire [16][17][18] which explores five different components of physical activity over 7 days. This questionnaire, validated against maximal oxygen consumption, is designed to provide a complete picture of a subject's usual physical activity.…”

Section: Other Measurementsmentioning

confidence: 99%

Autonomic Nervous System Activity and Decline as Prognostic Indicators of Cardiovascular and Cerebrovascular Events: The ‘PROOF’ Study

Barthélémy

Pichot

Dauphinot³

et al. 2007

Neuroepidemiology

111

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Background: Transversal studies have underlined the association between the decline in autonomic nervous system (ANS) activity and all-cause mortality. However, the predictive value of ANS has never been prospectively assessed in a general population-based cohort. Method: The PROOF (PROgnostic indicator OF cardiovascular and cerebrovascular events) cohort study was designed to prospectively assess the predictive value of ANS activity level in the general population, with regard to cardiovascular and cerebrovascular events, and death. This predictive power will be compared with the usual and newly discovered risk factors for the purposes of developing a risk model. Results: A prospective cohort of elderly subjects aged 65 years upon study entry were recruited from the electoral list of the city of Saint-Etienne, France. Three initial 2-year examination programs were scheduled for 7 years (2001–2007), followed by late events monitoring. At each examination, ANS activity was assessed along with clinical and biological cardiovascular risk factors, brain MRI, neuropsychological evaluation, physical activity profile, and sleep-related breathing disorders. The main study outcomes are stroke, myocardial infarction and death from any cause. A cohort consisting of 1,011 subjects aged 65.6 (0.8) years was constituted. Conclusion: Despite other selective characteristics, the associations between ANS activity and events will be applicable to other populations.

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Relationship between mean habitual daily energy expenditure and maximal oxygen uptake

Cited by 68 publications

References 0 publications

Reduced hip bone mineral density is related to physical fitness and leg lean mass in ambulatory individuals with chronic stroke

Reduced hip bone mineral density is related to physical fitness and leg lean mass in ambulatory individuals with chronic stroke

Rosiglitazone Improves Exercise Capacity in Individuals With Type 2 Diabetes

Autonomic Nervous System Activity and Decline as Prognostic Indicators of Cardiovascular and Cerebrovascular Events: The ‘PROOF’ Study

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