Relationship between mean platelet volume levels and subclinical target organ damage in newly diagnosed hypertensive patients

Yarlıoğlueş, Mikail; Kaya, Mehmet; Ardıç, İdris; Doğdu, Orhan; Kasapkara, Hacı Ahmet; Güntürk, Ertuğrul Emre; Akpek, Mahmut; Kalay, Nihat; Doğan, Ali; Özdoğru, İbrahіm; Oğuzhan, Abdurrahman

doi:10.3109/08037051.2010.532317

Cited by 49 publications

(47 citation statements)

References 45 publications

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“…However, there are great differences in the extent of target organ damage among patients even with similar levels of SBP and DBP. These differences have been attributed to a dipping/non-dipping pattern of BP and BP variability by some authors [4,5,6,7,8,17]. …”

Section: Discussionmentioning

confidence: 99%

“…Subjects in whom this nocturnal reduction in BP is blunted are named non-dippers whereas the others are classified as dippers [4,5,6,7,8]. Although the association between non-dipping hypertension and end-organ damage is still controversial, numerous studies have confirmed that non-dipping profiles are closely and independently associated with adverse cardiovascular outcomes and increased target organ damage [4,5,19].…”

Section: Discussionmentioning

confidence: 99%

“…Based on ambulatory BP measurements, hypertensive subjects are divided into two groups: dippers and non-dippers. Despite some conflicting reports, evidence indicates that non-dipper hypertension, which was defined as a reduction in nighttime BP of less than 10% compared to the daytime BP, carries a potential high risk for atherosclerosis, left ventricular hypertrophy, stroke, adverse coronary events, and renal failure [4,5,6,7,8]. Although the exact underlying mechanism leading to increased cardiovascular events in non-dippers is still unclear, some logical relations between non-dipping hypertension and target organ damage have been reported so far.…”

Section: Introductionmentioning

confidence: 99%

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Red Blood Cell Distribution Width in ‘Non-Dippers’ versus ‘Dippers’

et al. 2012

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Objectives: Because both high red cell distribution width (RDW) and non-dipping hypertension are closely related to adverse cardiovascular outcomes and higher inflammatory status, we aimed to investigate whether there is any relationship between RDW and dipping/non-dipping hypertension status. Methods: The present study involved 123 hypertensive patients and 65 age- and gender-matched healthy, normotensive subjects. Hypertensive patients were divided into two groups: 56 dipper patients (20 males, mean age 51.9 ± 15.3 years) and 67 non-dipper patients (27 males, mean age 55.6 ± 15.0 years). If the systolic daytime blood pressure (BP) of the patients decreased by at least 10% during the nighttime, these subjects were ‘dippers’, and all other subjects were ‘non-dippers’. Results: Both dipper patients and non-dipper patients had higher levels of RDW compared to normotensives (13.5 ± 0.89 and 14.1 ± 1.33 vs. 13.0 ± 1.42%, p = 0.027 and p <0.001, respectively). Also RDW values in non-dippers were statistically higher compared to those in dippers (p = 0.008). Although there were negative correlations between RDW values and nocturnal systolic BP fall (p = 0.027, r = –0.199) and diastolic BP fall (p = 0.383, r = –0.079) in all hypertensive patients, these correlations did not reach a statistically significant level. Conclusion: Our study demonstrates that non-dippers have high RDW levels compared to both dippers and controls.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Red Blood Cell Distribution Width in ‘Non-Dippers’ versus ‘Dippers’

et al. 2012

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“…Increased MPV has been demonstrated in diabetes (3)(4)(5)(6)(7)(8)(9). There are conflicting results about the relation of MPV with diabetic nephropathy/microalbuminuria (MA) (10)(11)(12)(13)(14)(15)(16)(17), diabetic neuropathy (18)(19)(20), coronary artery disease (4,13,18,(21)(22)(23)(24)(25), and cerebrovascular disease (3)(4)(5)26) in diabetic patients. Large platelets may play a role in the development of vascular damage in DR by being more active, forcing 2012.…”

Section: Introductionmentioning

confidence: 99%

The relationship of mean platelet volume with retinopathy in type 2 diabetes mellitus

Güngör¹,

Gürsoy

Güngör³

et al. 2016

Turk J Med Sci

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IntroductionDiabetes mellitus (DM), a major global health problem, is commonly associated with increased risk of developing micro-and macrovascular disease. Despite its clinical importance, the pathophysiology of diabetic complications is not completely understood. Platelets have been thought to be involved in these complications. Diabetic retinopathy (DR) is one of those important complications and leads to a considerable increase in morbidity.Platelet volume is a marker of platelet activation and function that can be measured easily as mean platelet volume (MPV) by clinical analyzers. It is now known that larger platelets are more reactive and produce more prothrombotic factors (1,2). Increased MPV has been demonstrated in diabetes (3-9). There are conflicting results about the relation of MPV with diabetic nephropathy/microalbuminuria (MA) (10-17), diabetic neuropathy (18-20), coronary artery disease (4,13,18,(21)(22)(23)(24)(25), and cerebrovascular disease (3-5,26) in diabetic patients. Large platelets may play a role in the development of vascular damage in DR by being more active, forcing the production of more prothrombotic factors, or causing endothelium-dependent vasomotor dysfunction.Keeping in mind these complex relations between MPV, diabetes, and its complications, in the present study we aimed to: 1) compare the MPV in diabetic patients with that in healthy controls; 2) determine if there is a difference in MPV between diabetic patients with and without DR, and also with and without proliferative retinopathy; 3) compare MPV levels of diabetic patients with or without hypertension (HTA), hyperlipemia (HL), and HTA with HL, and 4) see if there is a correlation of MPV with HbA1c and body mass index (BMI) in diabetic patients. Material and methods PatientsA total of 102 type 2 DM (T2DM) patients [65 female (63.7%), 35 male (36.3%)], 50 of them without retinopathy [31 female (62.0%), 19 male (38.0%)] and 52 with retinopathy [34 female (65.4%), 18 male (34.6%)], aged 22-90 years, were recruited from the Clinic of Ankara Education and Research Hospital from June 2009 to June Background/aim: Patients with diabetes mellitus have an increased risk of developing micro-and macrovascular complications. Retinopathy is one of the most important complications of diabetes whose pathophysiological cause has not yet been determined. One candidate may be platelet volume. In this study we aimed to investigate the association between mean platelet volume and diabetic retinopathy.Materials and methods: Mean platelet volume levels were investigated in type 2 diabetic patients with and without retinopathy, and in healthy participants. After reclassifying our diabetics in terms of the presence or absence of hypertension and hyperlipidemia, we compared their mean platelet volumes. We then checked to see if the mean platelet volume correlated with hemoglobin A1c and body mass index. Results:The mean platelet volume levels were higher in all diabetic patients, and they were highest in diabetics with retinopathy. The mean plate...

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“…Namely, damaged vascular cells release substances that activate platelets, and increase thrombogenesis and the potential for development of adverse CV events. (12,13) In this light, it is possible to interpret the results of studies that have shown associations between increased MPV with target organ damage in patients with hypertension and diabetes, (14,15) and also in patients with acute coronary syndrome. (19,20) As in acute coronary syndrome, in which rupture of the fibrous cap allows contact of the platelets with the highly thrombogenic necrotic core, (19,20) vascular damage, caused by multiple CV risk factors, enables contact between platelets and thrombogenic substances even in asymptomatic patients.…”

Section: Discussionmentioning

confidence: 99%

Correlation between mean platelet volume and total risk of cardiovascular disease

Marković

Carević

Bonacin

et al. 2013

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Introduction. The association between mean platelet volume (MPV) and single cardiovascular disease (CVD) risk factors has previously been tested. The aim of our study was to evaluate the association between MPV and total risk of CVD. Materials and Methods. In 216 consecutive outpatients referred for a cardiology assessment because of multiple CVD risk factors, total CVD risk was estimated according to the Framingham Risk Score (FRS) as low (<10%), intermediate (11-19%), and high (>20%). Additionally, FRS was adjusted for triglycerides (TG), body mass index (BMI) and a family history of CVD, important CVD risk factors which are not included in the FRS equation. Also, CVD risk was estimated according to terciles of MPV (<8.3, >9.1 fL, respectively). Correlation between high sensitivity C-reactive protein (hs-CRP) and FRS was used as confirmation that our study hypothesis was properly set. (OR 2.2; P =0.038). In comparison, P=0.004) and adjusted (r=0.383, P<0.001 Results. MPV did not correlate with individual CVD risk factors or with FRS, either before, or after adjustment for additional CVD risk factors. Significant correlation between MPV and total CV risk was observed only in the adjusted high FRS group; namely, for persons in tercile 3, CVD risk was doubled

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Relationship between mean platelet volume levels and subclinical target organ damage in newly diagnosed hypertensive patients

Cited by 49 publications

References 45 publications

Red Blood Cell Distribution Width in ‘Non-Dippers’ versus ‘Dippers’

Red Blood Cell Distribution Width in ‘Non-Dippers’ versus ‘Dippers’

The relationship of mean platelet volume with retinopathy in type 2 diabetes mellitus

Correlation between mean platelet volume and total risk of cardiovascular disease

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