Relationship between mean platelet volume and metabolic syndrome in Chinese patients

Abstract

Mean platelet volume (MPV) is a determinant of activation and variability of platelets (PLT). The focus of this study was to to investigate MPV values in patients with and without metabolic syndrome (MS). It also evaluates the association between them. There are close connections among MPV, MS, and cardiometabolic risk. We compiled age, body mass index, blood cell counts, MPV, and other data of 59976 self-reported healthy volunteers (28428 male, 31548 female), 24.65% of who have MS. The mean age of the group was 48.21 years old. The data was grouped by sex and values of data between men and women groups were analyzed by independent sample’s t-test. The relationship between sex and MS was evaluated by chi-square tests. Crude odd ratios of MS between MPV quartiles and 95% confidence intervals were analyzed by binary logistic regression in this study. We found women had higher levels of MPV (10.09 vs. 9.98, P < 0.01) and PLT (228.68 vs. 212.11, P < 0.01) than men. In females, the prevalence of MS was higher in low MPV group than in high MPV groups. The odds of having MS were significantly lower in higher MPV quartiles compared with MPV Quartile 1 in women (Adjusted OR < 1, P < 0.01). This study indicated that MS was inversely associated with MPV in females only.

Studies on Haemostatic Parameters of Type 2 Diabetics in Owerri, Imo State

“…This may be due to reduction in oestrogen and deletion of oestrogen receptor in aged female which is expresses by platelet. This observation is supported by studies conducted Cowman et al, [21]; Zhao et al, [22].…”

Study of Platelet Indices in Patients with Metabolic Syndrome

“…16 This sex-based female predisposition was noted by authors Zhou et al as well, who have shown that increasing plateletcrit acts as a predisposing factor to development of cardiovascular complications in MetS patients, and also noted an increased risk of developing MetS among patients with increased leucocyte and erythrocyte counts. 17,18 Furman et al noted that elevated platelet indices correlated statistically with waist circumferences of patients and acted as a determinant of abdominal obesity, a major factor implicated in the development of MetS, with similar results shown by authors Barzin et al as well. 19,20 Other platelet indices studied include platelet-tolymphocyte ratio, which was found to be elevated in MetS patients, as well as shown be a marker for cardiovascular dysfunction in MetS patients by Akboga et al 21,22 A large multicenter study based in South Korea, spanning 2 years from 2010 to 2012 and involving 2,228 patients by Lim et al, showed that elevated platelet indices were a risk stratification marker for development of MetS not only in adults but in the pediatric and adolescent population as well.…”

MiR-202-3p Inhibits Foam Cell Formation and is Associated with Coronary Heart Disease Risk in a Chinese Population

“…26,27) PDW and MPV are common platelet indices that have been identified as useful measures of platelet activation. 28,29) Previous studies have associated PDW or MPV with the occurrence and severity of coronary artery disease. Interestingly, we observed that the whole blood cell levels of miR-202-3p were negatively correlated with PDW and MPV in the CHD patients, and that miR-202-3p expression was negatively correlated with PDW and PCT in the control cases.…”