Relationship between measles and canine distemper viruses determined by delayed type hypersensitivity reactions in dogs

Brown, Albert L.; McCarthy, R.

doi:10.1038/248344a0

Cited by 18 publications

(12 citation statements)

References 3 publications

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“…This indicates that although no ILMC response was detected after the original immunization, some sensitization allowing the mounting of a secondary ILMC had occurred. Cross reacting cellular immune reactions with MV and CDV stimulated lymphoeytes had been reported previously (8,18). This response may be instrumental in curtailing disease development since it was shown b y APPEL et al (5) that recovery b y dogs positively correlated with the level of ILMC.…”

Section: Discussionmentioning

confidence: 91%

Measles virus and inactivated canine distemper virus induce incomplete immunity to canine distemper

Appel

Shek

Shesberadaran

et al. 1984

Archives of Virology

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Pairs of specific pathogen free dogs were immunized with two injections of heat inactivated canine distemper virus (CDV) or one injection of a live CDV or live measles virus (MV) vaccine. Three unimmunized dogs were used as controls. All 9 dogs were challenged with virulent CDV (Snyder Hill strain). The three unimmunized dogs developed severe signs of disease with a lethal infection in one. The two dogs immunized with live CDV vaccine developed a strong humoral as well as cellular immune response after immunization and were protected against virus replication. Animals immunized with either inactivated CDV or modified live MV failed to develop a measurable cellular immune response after immunization and had a comparatively weak humoral immune response to distemper antigens. They showed mild signs of infection after challenge and responded with strong anamnestic cellular and humoral immunity. The measles vaccine immunized dogs had a moderate serum titer of measles hemolysin-inhibiting antibodies which, after exposure to distemper virus, was boosted to high levels. It is proposed that this response plays a role in the mitigation of the virulent distemper infection in these animals.

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Section: Discussionmentioning

confidence: 91%

Measles virus and inactivated canine distemper virus induce incomplete immunity to canine distemper

Appel

Shek

Shesberadaran

et al. 1984

Archives of Virology

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“…This hypothesis is supported by the finding that T lymphocytes sensitized to Sindbis virus (a togavirus closely related to Chikungunya virus) are able to kill infected cells in vitro before viral maturation and release (15). It has also been observed that dogs sensitized with measles virus develop a delayed-type response to the related canine distemper virus and acquire a certain level of resistance to this virus, which is almost certainly due to cellular immunity mechanisms, as measles antibodies do not neutralize canine distemper virus in vitro (4).…”

Section: Discussionmentioning

confidence: 99%

Effect of anti-mu-chain-specific immunosuppression on Chikungunya virus encephalitis of mice

Giovarelli¹,

Viano²,

Zucca³

et al. 1977

Infect Immun

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Mice neonatally immunosuppressed with anti-,u antiserum failed to produce circulating antibodies to sheep erythrocytes and showed a marked decrease in circulating immunoglobulins. However, when they were intracerebrally infected with Chikungunya virus (a group A togavirus), they showed a mortality rate consistently lower than non-immunosuppressed control mice. Several possible explanations for this finding are discussed.

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“…The cross-protection among various prototypes of morbilliviruses is considered to be mediated mainly via cell-mediated immunity rather than cross-reacting antibodies (Brown and McCarthy, 1974;Gerber and Marron, 1976). However, antibodymediated cross protection may occur but that is not due to presence of neutralizing antibodies but rather due to cross-reactive antibodies that fix complement, resulting in death of infected cells without preventing virus infection in cell culture (Orvell and Norrby, 1980;Sheshberadaran et al, 1986).…”

Section: Cross Protection Among Morbillivirusesmentioning

confidence: 99%

Advances in peste des petits ruminants vaccines

Kumar

Barua

Riyesh

et al. 2017

Veterinary Microbiology

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Peste des petits ruminants (PPR) is a highly contagious disease of small ruminants that leads to high morbidity and mortality thereby results in devastating economic consequences to the livestock industry. PPR is currently endemic across most parts of Asia and Africa, the two regions with the highest concentration of poor people in the world. Sheep and goats in particularly contribute significantly towards the upliftment of livelihood of the poor and marginal farmers in these regions. In this context, PPR directly affecting the viability of sheep and goat husbandry has emerged as a major hurdle in the development of these regions. The control of PPR in these regions could significantly contribute to poverty alleviation, therefore, the Office International des Epizooties (OIE) and Food and Agricultural Organization (FAO) have targeted the control and eradication of PPR by 2030 a priority. In order to achieve this goal, a potent, safe and efficacious live-attenuated PPR vaccine with long-lasting immunity is available for immunoprophylaxis. However, the live-attenuated PPR vaccine is thermolabile and needs maintenance of an effective cold chain to deliver into the field. In addition, the infected animals cannot be differentiated from vaccinated animals. To overcome these limitations, some recombinant vaccines have been developed. This review comprehensively describes about the latest developments in PPR vaccines.

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Relationship between measles and canine distemper viruses determined by delayed type hypersensitivity reactions in dogs

Cited by 18 publications

References 3 publications

Measles virus and inactivated canine distemper virus induce incomplete immunity to canine distemper

Measles virus and inactivated canine distemper virus induce incomplete immunity to canine distemper

Effect of anti-mu-chain-specific immunosuppression on Chikungunya virus encephalitis of mice

Advances in peste des petits ruminants vaccines

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