Relationship between metabolic syndrome and thyroid nodules and thyroid volume in an adult population

Guo, Wenxing; Tan, Lei; Chen, Wen; Fan, Lili; Chen, Yanting; Du, Cong; Zhu, Mei; H, Wei; Wang, Wei; Gao, Min; Cui, Tingkai; Shen, Jun; Zhang, Wanqi

doi:10.1007/s12020-019-01901-4

Cited by 20 publications

(27 citation statements)

References 25 publications

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“…relationship of thyroid nodules with MetS and adiposity has been demonstrated in many studies. [3][4][5][6][18][19][20][21] Accordingly, in our study, we found that MetS was more common in individuals with thyroid nodules than in controls. Several studies reported a relationship between obesity and thyroid morphologic changes supporting the hypothesis that the hypothalamo/pituitary/thyroid/adipose tissue axis was disrupted.…”

Section: Vai In Patients With Thyroid Nodulessupporting

confidence: 54%

“…In the literature, there are many studies addressing the relationship between thyroid nodules and MetS. 5,[18][19][20][21] Diagnosis of MetS in someone with any thyroid disease can prevent the formation of new thyroid nodules or goiter. Even, there are studies showing that thyroid volume and nodules shrink or disappear with metformin treatment.…”

Section: Vai In Patients With Thyroid Nodulesmentioning

confidence: 99%

“…16,17 To date, many studies have been conducted on the relationship between MetS and thyroid volume and nodule frequency. 5,[18][19][20][21] However, in patients with thyroid nodules, the VAI, which better reflects visceral adipocyte function and insulin sensitivity and thus better predicts cardiometabolic risk, has not yet been studied. Therefore, we aimed to investigate the relationship between VAI and other MetS parameters, and thyroid nodules.…”

Section: Introductionmentioning

confidence: 99%

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Can “VAI” Better Indicate Metabolic Syndrome Compared with Other Metabolic Syndrome-Related Parameters in Patients with Thyroid Nodules? A Study from Turkey

Durcan

Şahin

Dedeoğlu

et al. 2021

Metabolic Syndrome and Related Disorders

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Background: To investigate the relationship between visceral adiposity index (VAI) and other metabolic syndrome (MetS)-related parameters, and thyroid nodules. Methods: This single-center, prospective, case-control study included 67 patients with thyroid nodules and 48 healthy volunteers with similar age, sex, and body mass index (BMI). Biochemical parameters were obtained from medical charts. Anthropometric measurements and total body composition analysis were performed to calculate VAI and other MetS parameters. The parenchymal structure was evaluated according to VESINC (Volume, Echogenicity, Sonographic texture, Infiltration of pseudonodular Nodules, Cysts) system on thyroid ultrasound and nodule characteristics were also detected. MetS was defined according to International Diabetes Federation criteria. Results: We examined a total of 67 patients with thyroid nodule and 48 healthy volunteers. Sixty-one (91%) were female in the patient group; and 43 (90%) were female in the control group. The mean age was 48.5 -11.6 years in the patient group; 47.2 -9.5 years in the control. The median VAI was significantly higher in the patient group than the control group [4.1 interquartile range (IQR: 2.6-5.9) vs. 3 (IQR: 2-4.3), P = 0.024]. There was a positive correlation between VAI and BMI, waist/hip ratio (WHpR), waist/height ratio (WHtR), and homeostasis of model assessment of insulin resistance (HOMA-IR). On the other hand, there was no significant correlation between VAI and thyroid function tests and autoantibodies and thyroid volume. Conclusions: In conclusion, we demonstrated that MetS was more common in patients with thyroid nodules. Although VAI and HOMA-IR levels were significantly different between the two groups, we found no significant difference in terms of waist circumference, WHpR, and WHtR. This might suggest that VAI compared with these parameters, better predicts the risk of MetS in patients with thyroid nodules.

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Section: Vai In Patients With Thyroid Nodulessupporting

confidence: 54%

Section: Vai In Patients With Thyroid Nodulesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Can “VAI” Better Indicate Metabolic Syndrome Compared with Other Metabolic Syndrome-Related Parameters in Patients with Thyroid Nodules? A Study from Turkey

Durcan

Şahin

Dedeoğlu

et al. 2021

Metabolic Syndrome and Related Disorders

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“…Since the insulin/insulin-like growth factor axis simulates the proliferation of thyroid follicular cells (5,6), it was hypothesized that compensatory hyperinsulinemia following insulin resistance in previous MetS might be responsible for the rising trend of TNs (7,8). In addition, increased incidence in TNs could be due to growing exposure to certain toxicants that may act as thyroid disruptors (9), and age may be another risk factor for TN development (10,11).…”

Section: Introductionmentioning

confidence: 99%

Association of Changes in Metabolic Syndrome Status With the Incidence of Thyroid Nodules: A Prospective Study in Chinese Adults

Liang

Chen

et al. 2020

Front. Endocrinol.

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Although several cross-sectional studies have shown an association of metabolic syndrome (MetS) with nodular thyroid disease, related prospective studies are scarce. This study investigated the association of MetS with thyroid nodule (TN) incidence in Chinese adults, and explored whether the development of or recovery from MetS is associated with changes in the risk of developing TNs. A total of 4,749 Chinese aged 18-65 years were involved in this 6-year prospective study. The association of MetS with TN prevalence was examined. TN-free individuals at baseline (n = 3,133) were further examined. TN incidence rates in groups with different MetS statuses (MetS-free, MetS-developed, MetS-recovery and MetS-chronic) were analyzed. Of all participants, 18.21 and 31.65% had MetS and TNs, respectively. MetS patients had a higher TN prevalence than the non-MetS group (31.08 vs. 19.81% in males, p < 0.01; 59.52 vs. 39.59% in females, p < 0.01). Sex, age and MetS were independent risk factors for TNs. At a median follow up of 5.94 years, the MetS-chronic group (4.37/100 person-years) had a higher risk of TNs (adjusted incidence rate ratio [IRR] = 1.288 [95% CI 1.014-1.636]) compared with the MetS-free group (2.72/100 person-years) in the whole cohort. In males, the MetS-chronic group (3.76/100 person-years) had a higher risk of TNs (adjusted IRR = 1.367 [95% CI 1.017-1.835]) compared with the MetS-free group (2.31/100 person-years). In females, the risk of TNs was significantly higher in the MetS-chronic (6.44/100 person-years) and MetS-developed (6.31/100 person-years) groups compared with the MetS-free group (3.23/100 person-years).

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“…Encontraron además que la RI se asociaba con mayor prevalencia de nódulos tiroideos, siendo éste un factor que aumentaba la chance de aparición (odds ratio [OR]: 3,2) [10] . En la actualidad ya se tienen estudios que relacionan al SM con la ENT [11][12][13][14] .…”

Section: Introductionunclassified

Presencia de nódulos tiroideos en pacientes con síndrome metabólico en un hospital de tercer nivel de atención peruano

et al. 2020

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Objetivo: comparar la frecuencia de enfermedad nodular tiroidea (ENT) en pacientes con síndrome metabólico (SM) y en pacientes sin SM en un área yodosuficiente. Materiales y métodos: estudio analítico, de casos y controles, comparativo de grupos pareados. Fueron 40 pacientes con SM y 40 controles, pareados por edad y sexo, los cuales acudieron al servicio de Endocrinología del Hospital Cayetano Heredia, Lima - Perú. El peso, talla y la presión arterial fueron tomadas de la historia clínica. Se evaluó el perímetro abdominal y la presencia de acantosis nigricans. Se midió perfil lipídico, glucosa basal y TSH. Se realizó ecografía tiroidea a todos los participantes. Se midió el volumen tiroideo y se consideró clínicamente significativo a nódulos tiroideos > 5 mm. Resultados: el 80 % de la población estudiada en ambos grupos fueron mujeres. Hubo diferencias significativas en el hábito tabáquico, la acantosis nigricans, la TSH, el volumen tiroideo, peso, índice de masa corporal, perímetro abdominal, presión diastólica, glucosa basal, HDL-colesterol y triglicéridos entre ambos grupos. La ENT fue más frecuente en los pacientes con SM que en los pacientes sin SM (40% vs. 12,5% respectivamente, p = 0,015). El odds ratio (OR) para presentar nódulos tiroideos en presencia de SM fue de 4,66 (intervalo de confianza al 95%: 1,34 - 16,24). Hubo diferencia significativa en el volumen tiroideo entre ambos grupos (p = 0,039). Conclusión: en una población de una zona yodosuficiente, el SM estuvo asociado a ENT y al incremento del volumen tiroideo.

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Relationship between metabolic syndrome and thyroid nodules and thyroid volume in an adult population

Cited by 20 publications

References 25 publications

Can “VAI” Better Indicate Metabolic Syndrome Compared with Other Metabolic Syndrome-Related Parameters in Patients with Thyroid Nodules? A Study from Turkey

Can “VAI” Better Indicate Metabolic Syndrome Compared with Other Metabolic Syndrome-Related Parameters in Patients with Thyroid Nodules? A Study from Turkey

Association of Changes in Metabolic Syndrome Status With the Incidence of Thyroid Nodules: A Prospective Study in Chinese Adults

Presencia de nódulos tiroideos en pacientes con síndrome metabólico en un hospital de tercer nivel de atención peruano

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