Relationship between methylenetetrahydrofolate reductase (MTHFR) gene (A1298C) polymorphism with the risk of stroke: A systematic review and meta-analysis

Kumar, Amit; Sharma, Ritika; Misra, Shubham; Nath, Manabesh; Kumar, Pradeep

doi:10.1080/01616412.2020.1798107

Cited by 11 publications

(12 citation statements)

References 38 publications

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“…This was undiscovered in early meta-analysis. Although Kumar et al [ 14 ] conducted a meta- analysis on association between A1298C polymorphism and risk of ischemic stroke. However, just 20 articles were included in this study, and some articles published in Chinese journal were not included in the analysis.…”

Section: Discussionmentioning

confidence: 99%

“…A meta-analysis study performed in 2014 reported the correlation between MTHFR A1298C polymorphism and adult stroke [ 13 ]. Although Kumar et al [ 14 ] conducted a meta- analysis and indicated that genotyping of MTHFR gene A1298C polymorphism may be used as a predictor for the occurrence of ischemic stroke. However, just 20 articles were included in this study, and some articles published in Chinese journal were not included in the analysis.…”

Section: Introductionmentioning

confidence: 99%

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MTHFR A1298C gene polymorphism on stroke risk: an updated meta-analysis

Dong

Wang

et al. 2021

Genes and Environ

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Background Previous studies have shown the effect of MTHFR A1298C gene polymorphism on stroke risk. But the results of published studies remained inconclusive and controversial. So we conducted a meta-analysis to accurately estimate the potential association between MTHFR A1298C gene polymorphism and stroke susceptibility. Methods A systematic literature search on Embase, Pubmed, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI) and WanFang electronic database identified 40 articles including 5725 cases and 8655 controls. Strength of association was evaluated by pooled odds ratio (OR), 95% confidence interval (CI) and p value. Funnel plots and Begger’s regression test were applied for testing the publication bias. Statistical analysis of all data was performed by Stata 12.0. Results The meta-analysis results indicated a significant relationship between MTHFR gene A1298C polymorphisms and stoke risk under the C allelic genetic model (OR = 1.19, 95%CI = 1.07–1.32, p = 0.001), dominant genetic model (OR = 1.19, 95%CI = 1.06–1.33, p = 0.004) and recessive genetic model (OR = 1.43, 95%CI =1.15–1.77, p = 0.001). In subgroup analysis, we discovered obvious correlation in three genetic model of Asian, stroke type, adult by ethnicity, population, stroke type, source of control and case size. Additionally, in studies of control from hospital and case size equal 100, obvious correlation was also found in the three genetic model. Conclusions Our meta-analysis results indicated that there was evidence to support the correlation between MTHFR A1298C polymorphism and stroke susceptibility, especially in adults and ischemic stroke.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MTHFR A1298C gene polymorphism on stroke risk: an updated meta-analysis

Dong

Wang

et al. 2021

Genes and Environ

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“…Emerging evidences from published meta-analysis and GWAS studies suggests that several genetic variants (MTHFR, MMP9, PDE4D, CYP4A11, ALOX5P, NOTCH, NINJ2, FGB, eNOS, PITX2, ZFHX3, HDAC9, ABO, etc) have been identified, even though the extent of the effect of each variant is regarded as inter-varying within different populations including Asian, Caucasian, African. [1,1,7,14,[35][36][37][38][39][39][40][41][42][43][44] The findings, however, are often unclear and hard to interpret. Genetic association studies in diverse stroke populations negate matters of the restricted patient population by the a priori choice of a functionally relevant gene and its relation with a specific phenotype.…”

Section: Discussionmentioning

confidence: 99%

Potential Key Genes Associated with Stroke types and its subtypes: A Computational Approach

Das

Kumar

2021

Preprint

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To investigate prospective key genes and pathways associated with the pathogenesis and prognosis of stroke types along with subtypes. Human genes using genome assembly build 38 patch release 13 with known gene symbols through NCBI gene database (https://www.ncbi.nlm.nih.gov/gene) were fetched. PubMed advanced queries were constructed using stroke-related keywords and associations were calculated using Normalized pointwise mutual information (nPMI) between each gene symbol and queries. Genes related with stroke risk within their types and subtypes were investigated in order to discover genetic markers to predict individuals who are at the risk of developing stroke with their subtypes. A total of 2,785 (9.4%) genes were found to be linked to the risk of stroke. Based on stroke types, 1,287 (46.2%) and 376 (13.5%) genes were found to be related with IS and HS respectively. Further stratification of IS based on TOAST classification, 86 (6.6%) genes were confined to Large artery atherosclerosis; 131 (10.1%) and 130 (10%) genes were related with the risk of small vessel disease and Cardioembolism subtypes of IS. Besides, a prognostic panel of 9 genes signature consisting of CYP4A11, ALOX5P, NOTCH, NINJ2, FGB, MTHFR, PDE4D, HDAC9, and ZHFX3 can be treated as a diagnostic marker to predict individuals who are at the risk of developing stroke with their subtypes.

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“…The association between various polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and stroke have been investigated in many studies with conflicting reports, with metaanalyses overall showing a weak association between stroke and the C677T and A1298C MTHFR polymorphisms. [2][3][4] Interestingly, MTHFR polymorphisms have been reported to be associated with cigarette smoking behavior, 5 thus serving as a potential confounder in the relationship between MTHFR polymorphisms and thrombotic risk reported in observational studies. A recent large multinational case-control study confirmed that current smoking is an independent risk factor for ischemic stroke, 6 and another large study found an association between smoking and stroke recurrence risk.…”

Section: Traditional Risk Factors and Combined Genetic Markers Of Rec...mentioning

confidence: 99%

“…In our Tunisian population, we showed the association between MTHFR polymorphisms and the occurrence of stroke in young people. 1,2 The follow-up of these patients revealed that most patients carrying the MTHFR polymorphism and especially those who have genetic combinations will have a second stroke. On this basis we have carried out this study.…”

Section: Traditional Risk Factors and Combined Genetic Markers Of Rec...mentioning

confidence: 99%

Traditional risk factors and combined genetic markers of recurrent ischemic stroke in adults: Comment from Wilson et al.

Wilson

Moll

2022

Journal of Thrombosis and Haemostasis

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Relationship between methylenetetrahydrofolate reductase (MTHFR) gene (A1298C) polymorphism with the risk of stroke: A systematic review and meta-analysis

Cited by 11 publications

References 38 publications

MTHFR A1298C gene polymorphism on stroke risk: an updated meta-analysis

MTHFR A1298C gene polymorphism on stroke risk: an updated meta-analysis

Potential Key Genes Associated with Stroke types and its subtypes: A Computational Approach

Traditional risk factors and combined genetic markers of recurrent ischemic stroke in adults: Comment from Wilson et al.

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