Relationship between microvessel density and telomerase activity in hepatocellular carcinoma

Piao, Yun-Song; He, Min; Shi, Yang; Tang, Tongyu

doi:10.3748/wjg.v10.i14.2147

Cited by 11 publications

(9 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…MVC was not associated with any clinicopathological factors or recurrence rate after hepatectomy in either the present study or our pilot study [17] . In contrast to our results, El-Assal et al [30] and other investigators [6,14,15,[30][31][32] have reported that microvessel density in HCC is increased in larger tumors, tumors with poor differentiation and cirrhotic patients, while higher microvessel density is associated with intra-hepatic recurrence. In the present study, however, MVC did not correlate with co-existing cirrhosis or with various etiological factors related to chronic hepatitis such as viral status.…”

Section: Discussioncontrasting

confidence: 99%

“…The role of MVC for tumor relapse or progression might not be particularly strong. This result contradicts findings in other reports described above [6,14,16,30,31] . As explained above, HCC naturally acquires rich tumor vascularity in the early stages and most clinically treated HCCs represent tumor with radiological enhancement [34,35,38] .…”

Section: Overall Survival Rate (%)contrasting

confidence: 88%

“…Levels of angiogenic factors such as vascular endothelial growth factor (VEGF) or basic fibroblast growth factor (b-FGF) are increased in HCC and might affect patient survival [12,13] . Recent studies have also shown that microvessel density (MVD) in HCC or noncancerous liver surrounding tumor correlates with tumor aggressiveness and prognosis [6,[14][15][16] . We have previously provided a preliminary demonstration of the comprehensive analysis of various biological factors, revealing that microvessel count (MVC) using CD34 antibody was independently associated with poor prognosis in HCC patients undergoing hepatic resection by multivariate analysis [17] .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Relationship between microvessel count and post-hepatectomy survival in patients with hepatocellular carcinoma

Nanashima¹,

Nakayama²,

Sumida³

et al. 2008

WJG

View full text Add to dashboard Cite

AIM:To elucidate the relationship between the microvessel count (MVC) by CD34 analyzed by immunohistochemical method and prognosis in h e p a t o c e l l u l a r c a r c i n o m a ( H C C ) p a t i e n t s w h o underwent hepatectomy based on our preliminary study. METHODS:We examined relationships between MVC and clinicopathological factors in 128 HCC patients. The modified Japan Integrated Staging score (mJIS) was applied to examine subsets of HCC patients. RESULTS: Median MVC was 178/mm 2 , which was used as a cut-off value. MVC was not significantly associated with any clinicopathologic factors or postoperative recurrent rate. Lower MVC was associated with poor disease-free and overall survivals by univariate analysis (P = 0.039 and P = 0.087, respectively) and lower MVC represented an independent poor prognostic factor in disease-free survival by Cox's multivariate analysis (risk ratio, 1.64; P = 0.024), in addition to tumor size, vascular invasion, macroscopic finding and hepatic dysfunction. Significant differences in diseasefree and overall survivals by MVC were observed in HCC patients with mJIS 2 (P = 0.046 and P = 0.0014, respectively), but not in those with other scores. CONCLUSION: Tumor MVC appears to offer a useful prognostic marker of HCC patient survival, particularly in HCC patients with mJIS 2.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Overall Survival Rate (%)contrasting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship between microvessel count and post-hepatectomy survival in patients with hepatocellular carcinoma

Nanashima¹,

Nakayama²,

Sumida³

et al. 2008

WJG

View full text Add to dashboard Cite

show abstract

“…We found that there was no difference in intratumoural TMA levels detected at different time points of tumour growth suggesting that TMA levels in tumour tissue are independent of tumour size. This is similar to the results of Piao et al, 18 who found no correlation with TMA activity and tumour size. However, we found that TMA in the peritumoural tissue increased with time, along with the growth of the implanted tumour.…”

Section: Discussionsupporting

confidence: 82%

Telomerase activity (TMA) in tumour and peritumoural tissues in a rat liver cancer model

Zhang

Yang

Tian³

et al. 2009

CIM

View full text Add to dashboard Cite

show abstract

“…19 On the other hand, another report showed that telomerase activation was signi cantly related to the poor tumor differentiation of HCC tumors. 24 In thyroid cancer, TERT promoter mutation was frequently observed in poorly differentiated tumors. 25 The role of TERT is not only the acquisition of tumor immortality, but also interactions with several oncogenic pathways such as the Wnt/beta-catenin signal pathway and p53 suppression.…”

Section: Discussionmentioning

confidence: 99%

Significance of Cytoplasmic Expression of Telomerase Reverse Transcriptase in Patients with Hepatocellular Carcinoma Undergoing Liver Resection

Nishi

Aoki

Shioiri

et al. 2021

Preprint

View full text Add to dashboard Cite

Telomerase reverse transcriptase (TERT) is reportedly expressed in various types of cancer. However, the significance of TERT expression in hepatocellular carcinoma (HCC) has not been fully evaluated. Herein, we evaluated TERT expression in resected HCC tumor tissues using immunohistochemistry. TERT expression was assessed in both the cytoplasm and the nucleus of HCC cells. The relationships between TERT expression and clinical characteristics were investigated. Among the 135 HCCs, TERT expression was positive only in the cytoplasm in 86 tumors (63.7%), was positive only in the nucleus in 3 tumors (2.2%), was positive in both the cytoplasm and the nucleus in 5 tumors (3.7%) and was negative in 41 tumors (30.4%). Cytoplasmic TERT expression was significantly associated with HBs antigen, poor tumor differentiation, and DNA-dependent protein kinase catalytic unit (DNA-PKcs) expression. However, TERT expression in the cytoplasm or in the nucleus was not significantly correlated with the overall or the recurrence-free survival periods. In conclusion, TERT was mainly expressed in the cytoplasm of HCC tissues. Cytoplasmic TERT expression is closely associated with HBV-related HCC and DNA-PKcs expression. The overexpression of TERT and DNA-PKcs arise from cccDNA and may be related to liver carcinogenesis in the presence of HBV infection.

show abstract

Relationship between microvessel density and telomerase activity in hepatocellular carcinoma

Abstract: MVD and telomerase activity may serve as diagnostic criteria of HCC in earlier stage. Meanwhile, there may be a cooperative effect between MVD and telomerase on the growth and metastasis of HCC.

Cited by 11 publications

References 21 publications

Relationship between microvessel count and post-hepatectomy survival in patients with hepatocellular carcinoma

Relationship between microvessel count and post-hepatectomy survival in patients with hepatocellular carcinoma

Telomerase activity (TMA) in tumour and peritumoural tissues in a rat liver cancer model

Significance of Cytoplasmic Expression of Telomerase Reverse Transcriptase in Patients with Hepatocellular Carcinoma Undergoing Liver Resection

Contact Info

Product

Resources

About