2006
DOI: 10.1080/03079450601028803
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Relationship between mortality, clinical signs and tracheal pathology in infectious laryngotracheitis

Abstract: Previous studies in our laboratory using a combination of polymerase chain reaction and restriction fragment length polymorphism have identified at least five different genotypes of infectious laryngotracheitis virus (ILTV). However, the virulence of these classes of ILTV was not investigated. In this study, five groups (16 birds each) of 3-week-old specific pathogen free chickens were inoculated via the intratracheal route with 10 3 median embryo infected dose of five different strains of ILTV. Three further … Show more

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Cited by 62 publications
(47 citation statements)
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“…The strain circulating in Indian poultry might have virulence for all ages. Recent work has confirmed considerable variation among ILTV strains in their tropism, capacity to induce mortality, clinical signs and lesions in different tissues [18]. In the current investigation, all the ILT affected farms had the past history of similar clinical disease in the same or neighboring farms indicating that virus persistence in farm environments leading to spread of disease.…”
Section: Discussionsupporting
confidence: 66%
“…The strain circulating in Indian poultry might have virulence for all ages. Recent work has confirmed considerable variation among ILTV strains in their tropism, capacity to induce mortality, clinical signs and lesions in different tissues [18]. In the current investigation, all the ILT affected farms had the past history of similar clinical disease in the same or neighboring farms indicating that virus persistence in farm environments leading to spread of disease.…”
Section: Discussionsupporting
confidence: 66%
“…ILTV showed a more extensive replication in the conjunctival mucosa compared with the tracheal mucosa. The differences in the replication kinetics of ILTV are probably due to variation in its tropism for the trachea and conjunctiva, an observation reported previously by Kirkpatrick et al (2006). In the future, a study of the replication characteristics of different ILTV strains on mucosal explants may help to understand their tropism for the trachea and conjunctiva.…”
Section: Discussionmentioning
confidence: 61%
“…The replication characteristics of ILTV in the respiratory and conjunctival mucosa may be investigated by performing animal experiments (Bang & Bang, 1967;Kirkpatrick et al, 2006). However, in vivo studies are contested more and more for ethical reasons.…”
Section: Introductionmentioning
confidence: 99%
“…In severe forms of the disease, haemorrhagic tracheitis together with gasping, coughing, and expectoration of bloody mucus are common. ILT occurs worldwide, and morbidity and mortality rates vary depending on the virulence of the circulating strain (Kirkpatrick et al, 2006a;Oldoni et al, 2009), the levels of virus circulating in the field and infections with other respiratory diseases of poultry (Guy & Garcia, 2008). With an overall mortality due to ILT that can reach 70%, large economic losses usually occur in highdensity poultry-producing regions (Bagust et al, 2000).…”
Section: Introductionmentioning
confidence: 99%
“…In 1966, an Australian field isolate attenuated by serial passages in chick embryos resulted in the CEO SA2 vaccine strain. By 1983 the SA2 vaccine strain was further attenuated, in chicken embryonic cell cultures, to generate the A20 vaccine strain (Kirkpatrick et al, 2006a). The European Serva vaccine is also a chicken embryo passaged attenuated strain, but its exact origin is not known.…”
Section: Introductionmentioning
confidence: 99%