Relationship between MRI quantified small bowel motility and abdominal symptoms in Crohn’s disease patients—a validation study

Gollifer, R; Menys, Alex; Makanyanga, Jesica; Puylaert, Carl A. J.; Vos, Frans M.; Stoker, Jaap; Atkinson, David; Taylor, Stuart A.

doi:10.1259/bjr.20170914

Cited by 14 publications

(13 citation statements)

References 33 publications

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“…Taken together with previous publications, the reduced motility in active CD may reflect signs of increased inflammation 11,16,17 . In addition, the correlation between motility variance and symptoms in patients with high activity scores suggests that measurement of motility by MRE is most suitable for patients with active, inflammatory disease 15 . Measurement of MI or motility variance may not be an independent marker of neurogenic and/or myogenic dysmotility, but may rather reflect changes on MRE due to inflammatory activity.…”

Section: Discussionsupporting

confidence: 54%

“…However, the sensitivity and specificity for MI were lower in the present study of an unselected cohort, compared with selected study cohorts, and the optimal cutoffs in MI presented in a previous report could not be confirmed 6 . Our findings of absence of correlation between symptoms and MI are in accordance with Gollifer et al 15 On the other hand, that study could demonstrate a correlation between motility variance metric, values not analyzed in the present study, and the number of diarrheal stools and symptoms in subgroup analyses of patients with high activity scores 15 . Nevertheless, the concordance between subjectively observed motility reduction and MI in the present study suggests that MI still is a representative metric to assess motility.…”

Section: Discussionsupporting

confidence: 50%

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Volumetric analysis of small bowel motility in an unselected cohort of patients with Crohn’s disease

Dreja

Ekberg

Leander

et al. 2020

Neurogastroenterology Motil

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Background Quantified terminal ileal motility during magnetic resonance enterography (MRE) has been suggested to be used as a biomarker of Crohn's disease (CD). The aim of the present study was to evaluate this method in clinical practice. Methods Healthy volunteers and all consecutive patients referred to MRE during a 2‐year period were asked to participate and complete the Irritable Bowel Syndrome‐Symptom Severity Scale (IBS‐SSS) to assess gastrointestinal symptoms. Medical records were scrutinized, and motility indices (MIs) were calculated from MR images. Key Results Twenty‐two healthy controls and 134 examinations with CD were included (inclusion rate: 76.3%). Patients with CD had increased mural thickness of the terminal ileum, increased fecal calprotectin, and more symptoms than controls. Patients with active CD had increased mural thickness of ileum and terminal ileum, higher MR activity indices, and signs of inflammation in laboratory analyses, but similar symptoms, compared with inactive disease. After exclusion of sole colon disease (n = 13), MI inversely correlated with mural thickness in terminal ileum, and MI was lower in active disease versus controls in ileum (P = .019) and terminal ileum (P = .005), and versus inactive disease in terminal ileum (P = .044). The area under the curve of MI in terminal ileum was 0.736 for active CD against healthy controls (P = .002) and 0.682 for active against inactive CD (P = .001). MIs were similar in controls and inactive CD. Conclusions and Interferences MI reflects inflammatory activity in the intestine. Alterations in MI did not explain symptomatology in inactive CD, without measurable inflammatory parameters in morphology or laboratory analyses.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionsupporting

confidence: 50%

Volumetric analysis of small bowel motility in an unselected cohort of patients with Crohn’s disease

Dreja

Ekberg

Leander

et al. 2020

Neurogastroenterology Motil

View full text Add to dashboard Cite

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“…MRI measurements of the stomach and small bowel motility have been the subject of various studies since the late 1990s [37], developing to now include automated analysis of the data generated [38]. Some of these methods have shown the potential for clinical translation, e.g., motility alternations and patient-reported symptoms [39]. MRI of the motility of the colon has only recently started to be addressed [40].…”

Section: Assessing Particle Motion In Dcm Using Peptmentioning

confidence: 99%

Dynamic Colon Model (DCM): A Cine-MRI Informed Biorelevant In Vitro Model of the Human Proximal Large Intestine Characterized by Positron Imaging Techniques

et al. 2020

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This work used in vivo MRI images of human colon wall motion to inform a biorelevant Dynamic Colon Model (DCM) to understand the interplay of wall motion, volume, viscosity, fluid, and particle motion within the colon lumen. Hydrodynamics and particle motion within the DCM were characterized using Positron Emission Tomography (PET) and Positron Emission Particle Tracking (PEPT), respectively. In vitro PET images showed that fluid of higher viscosity follows the wall motion with poor mixing, whereas good mixing was observed for a low viscosity fluid. PEPT data showed particle displacements comparable to the in vivo data. Increasing fluid viscosity favors the net forward propulsion of the tracked particles. The use of a floating particle demonstrated shorter residence times and greater velocities on the liquid surface, suggesting a surface wave that was moving faster than the bulk liquid. The DCM can provide an understanding of flow motion and behavior of particles with different buoyancy, which in turn may improve the design of drug formulations, whereby fragments of the dosage form and/or drug particles are suspended in the proximal colon.

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“…A proportion of patient data (n=28) used in the current study was also used in previous work investigating the relationship between two motility metrics (mean global motility and variance of global motility) and abdominal symptoms 6,7 .…”

Section: Patient Selectionmentioning

confidence: 99%

“…It is well established that motility is reduced in segments of bowel affected by Crohn's disease, and that this reduction is correlated with the severity of inflammation 4,5 . However recent work using automated software quantification has suggested that aberrant motility in apparently unaffected bowel, based on visual assessment, is linked to the severity of abdominal symptoms 6,7 . The ability of MRE to capture abnormal motility patterns in structurally normal bowel could prove a powerful tool in improving our understanding of gastrointestinal (GI) motility in health and disease.…”

Section: Introductionmentioning

confidence: 99%

Automated versus subjective assessment of spatial and temporal MRI small bowel motility in Crohn's disease

et al. 2019

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Relationship between MRI quantified small bowel motility and abdominal symptoms in Crohn’s disease patients—a validation study

Abstract: Cite this article as: Gollifer RM, Menys A, Makanyanga J, Puylaert CAJ, Vos FM, Stoker J, et al. Relationship between MRI quantified small bowel motility and abdominal symptoms in Crohn's disease patients-a validation study. Br J Radiol 2018; 91: 20170914.

Cited by 14 publications

References 33 publications

Volumetric analysis of small bowel motility in an unselected cohort of patients with Crohn’s disease

Volumetric analysis of small bowel motility in an unselected cohort of patients with Crohn’s disease

Dynamic Colon Model (DCM): A Cine-MRI Informed Biorelevant In Vitro Model of the Human Proximal Large Intestine Characterized by Positron Imaging Techniques

Automated versus subjective assessment of spatial and temporal MRI small bowel motility in Crohn's disease

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